Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones
Backround: The present study focused on cholecystectomized elderly patients and aimed to investigate whether inflammation in the gallbladder wall was associated with the number and size of gallstones, as well as the patients' age. Patients and Methods: The present study included 306 cholecystec...
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| Veröffentlicht in: | In vivo (Athens) 2008-03, Vol.22 (2), p.269-272 |
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| creator | Domeyer, Philip J Sergentanis, Theodoros N Zagouri, Flora Tzilalis, Basileios Mouzakioti, Elena Parasi, Aggeliki Nonni, Afroditi Mariolis, Anargiros Androulakis, George Zografos, George C |
| description | Backround: The present study focused on cholecystectomized elderly patients and aimed to investigate whether inflammation
in the gallbladder wall was associated with the number and size of gallstones, as well as the patients' age. Patients and
Methods: The present study included 306 cholecystectomized patients aged over 65 years. From the specimens derived from cholecystectomy,
the gallstone number, the largest gallstone diameter and gallbladder wall thickness were determined. According to the histopathological
examination, chronic inflammation was subdivided into mild-moderate and severe. Univariable analysis and multivariable logistic
regression followed. Results: Mild-moderate inflammation characterized 63.4% of the cases and severe inflammation 36.6%. Solitary
gallstones were found in 13.1% of the cases, while multiple gallstones were found in 86.9% of the cases. The largest gallstone
diameter was less than 1 cm in the majority of cases (73.2%). The gallbladder wall thickness was associated with the degree
of inflammation (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69196412</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69196412</sourcerecordid><originalsourceid>FETCH-LOGICAL-h238t-62a9a2010ca8747192f5b33d47eb1ea11f1a1c6d5c3f567f97dc69b2501b8bc13</originalsourceid><addsrcrecordid>eNo90N9LwzAQB_AgipvTf0HyIL5VkrRNm0cp_hgMFabgW0nTq42k6UzSjQn-71Y35R6OL_e5e7gDNKWZoFGWJuIQTQlL8yhP6esEnXj_TgjPCGHHaELzhOcJTaboq2hdb7XCRdsbUFsfdNAea4tvTA3ObPGTDBps8Fe46J0DM8be4r7BoQW8hDU4HbY_eW4bI7tuN9_o0P6Kh6GrwGFpa7zUn_C_GHoL_hQdNdJ4ONv3GXq5vXku7qPF4928uF5ELYvzEHEmhWSEEiXzLMmoYE1axXGdZFBRkJQ2VFLF61TFTcqzRmS14qJiKaFVXikaz9Dl7u7K9R8D-FB22iswRlroB19yQQVPKBvh-R4OVQd1uXK6k25b_j1sBBc70Oq3dqMdlL6Txow8LvWasXIsLuJvwBx2GA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69196412</pqid></control><display><type>article</type><title>Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Domeyer, Philip J ; Sergentanis, Theodoros N ; Zagouri, Flora ; Tzilalis, Basileios ; Mouzakioti, Elena ; Parasi, Aggeliki ; Nonni, Afroditi ; Mariolis, Anargiros ; Androulakis, George ; Zografos, George C</creator><creatorcontrib>Domeyer, Philip J ; Sergentanis, Theodoros N ; Zagouri, Flora ; Tzilalis, Basileios ; Mouzakioti, Elena ; Parasi, Aggeliki ; Nonni, Afroditi ; Mariolis, Anargiros ; Androulakis, George ; Zografos, George C</creatorcontrib><description>Backround: The present study focused on cholecystectomized elderly patients and aimed to investigate whether inflammation
in the gallbladder wall was associated with the number and size of gallstones, as well as the patients' age. Patients and
Methods: The present study included 306 cholecystectomized patients aged over 65 years. From the specimens derived from cholecystectomy,
the gallstone number, the largest gallstone diameter and gallbladder wall thickness were determined. According to the histopathological
examination, chronic inflammation was subdivided into mild-moderate and severe. Univariable analysis and multivariable logistic
regression followed. Results: Mild-moderate inflammation characterized 63.4% of the cases and severe inflammation 36.6%. Solitary
gallstones were found in 13.1% of the cases, while multiple gallstones were found in 86.9% of the cases. The largest gallstone
diameter was less than 1 cm in the majority of cases (73.2%). The gallbladder wall thickness was associated with the degree
of inflammation (p<0.001, Chi-square). In the univariable analysis, inflammation was positively associated with the diameter
of the largest gallstone (p=0.032, Chi-square), but negatively associated with the number of gallstones (p<0.001, Chi-square)
and patients< age (p=0.008, logistic regression). The number of gallstones was negatively associated with the diameter of
gallstones and positively associated with the patients< age. The diameter of the largest gallstone was negatively associated
with the patients< age. In the multivariable logistic regression, the effect of age (OR=0.95, 95% CI: 0.91-0.99) and solitary
gallstones (OR=2.66, 95% CI: 1.02-6.93) on inflammation persisted, but that of the largest gallstone diameter vanished. Conclusion:
The elderly population presented mainly with multiple and small gallstones. Solitary gallstones and younger age were the most
important predictors for severe inflammation.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 18468414</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Aged ; Aged, 80 and over ; Cholecystitis - pathology ; Chronic Disease ; Female ; Gallbladder - pathology ; Gallstones - pathology ; Humans ; Inflammation - immunology ; Male ; Severity of Illness Index</subject><ispartof>In vivo (Athens), 2008-03, Vol.22 (2), p.269-272</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18468414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domeyer, Philip J</creatorcontrib><creatorcontrib>Sergentanis, Theodoros N</creatorcontrib><creatorcontrib>Zagouri, Flora</creatorcontrib><creatorcontrib>Tzilalis, Basileios</creatorcontrib><creatorcontrib>Mouzakioti, Elena</creatorcontrib><creatorcontrib>Parasi, Aggeliki</creatorcontrib><creatorcontrib>Nonni, Afroditi</creatorcontrib><creatorcontrib>Mariolis, Anargiros</creatorcontrib><creatorcontrib>Androulakis, George</creatorcontrib><creatorcontrib>Zografos, George C</creatorcontrib><title>Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Backround: The present study focused on cholecystectomized elderly patients and aimed to investigate whether inflammation
in the gallbladder wall was associated with the number and size of gallstones, as well as the patients' age. Patients and
Methods: The present study included 306 cholecystectomized patients aged over 65 years. From the specimens derived from cholecystectomy,
the gallstone number, the largest gallstone diameter and gallbladder wall thickness were determined. According to the histopathological
examination, chronic inflammation was subdivided into mild-moderate and severe. Univariable analysis and multivariable logistic
regression followed. Results: Mild-moderate inflammation characterized 63.4% of the cases and severe inflammation 36.6%. Solitary
gallstones were found in 13.1% of the cases, while multiple gallstones were found in 86.9% of the cases. The largest gallstone
diameter was less than 1 cm in the majority of cases (73.2%). The gallbladder wall thickness was associated with the degree
of inflammation (p<0.001, Chi-square). In the univariable analysis, inflammation was positively associated with the diameter
of the largest gallstone (p=0.032, Chi-square), but negatively associated with the number of gallstones (p<0.001, Chi-square)
and patients< age (p=0.008, logistic regression). The number of gallstones was negatively associated with the diameter of
gallstones and positively associated with the patients< age. The diameter of the largest gallstone was negatively associated
with the patients< age. In the multivariable logistic regression, the effect of age (OR=0.95, 95% CI: 0.91-0.99) and solitary
gallstones (OR=2.66, 95% CI: 1.02-6.93) on inflammation persisted, but that of the largest gallstone diameter vanished. Conclusion:
The elderly population presented mainly with multiple and small gallstones. Solitary gallstones and younger age were the most
important predictors for severe inflammation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cholecystitis - pathology</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Gallbladder - pathology</subject><subject>Gallstones - pathology</subject><subject>Humans</subject><subject>Inflammation - immunology</subject><subject>Male</subject><subject>Severity of Illness Index</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90N9LwzAQB_AgipvTf0HyIL5VkrRNm0cp_hgMFabgW0nTq42k6UzSjQn-71Y35R6OL_e5e7gDNKWZoFGWJuIQTQlL8yhP6esEnXj_TgjPCGHHaELzhOcJTaboq2hdb7XCRdsbUFsfdNAea4tvTA3ObPGTDBps8Fe46J0DM8be4r7BoQW8hDU4HbY_eW4bI7tuN9_o0P6Kh6GrwGFpa7zUn_C_GHoL_hQdNdJ4ONv3GXq5vXku7qPF4928uF5ELYvzEHEmhWSEEiXzLMmoYE1axXGdZFBRkJQ2VFLF61TFTcqzRmS14qJiKaFVXikaz9Dl7u7K9R8D-FB22iswRlroB19yQQVPKBvh-R4OVQd1uXK6k25b_j1sBBc70Oq3dqMdlL6Txow8LvWasXIsLuJvwBx2GA</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Domeyer, Philip J</creator><creator>Sergentanis, Theodoros N</creator><creator>Zagouri, Flora</creator><creator>Tzilalis, Basileios</creator><creator>Mouzakioti, Elena</creator><creator>Parasi, Aggeliki</creator><creator>Nonni, Afroditi</creator><creator>Mariolis, Anargiros</creator><creator>Androulakis, George</creator><creator>Zografos, George C</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones</title><author>Domeyer, Philip J ; Sergentanis, Theodoros N ; Zagouri, Flora ; Tzilalis, Basileios ; Mouzakioti, Elena ; Parasi, Aggeliki ; Nonni, Afroditi ; Mariolis, Anargiros ; Androulakis, George ; Zografos, George C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-62a9a2010ca8747192f5b33d47eb1ea11f1a1c6d5c3f567f97dc69b2501b8bc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cholecystitis - pathology</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Gallbladder - pathology</topic><topic>Gallstones - pathology</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Male</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domeyer, Philip J</creatorcontrib><creatorcontrib>Sergentanis, Theodoros N</creatorcontrib><creatorcontrib>Zagouri, Flora</creatorcontrib><creatorcontrib>Tzilalis, Basileios</creatorcontrib><creatorcontrib>Mouzakioti, Elena</creatorcontrib><creatorcontrib>Parasi, Aggeliki</creatorcontrib><creatorcontrib>Nonni, Afroditi</creatorcontrib><creatorcontrib>Mariolis, Anargiros</creatorcontrib><creatorcontrib>Androulakis, George</creatorcontrib><creatorcontrib>Zografos, George C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domeyer, Philip J</au><au>Sergentanis, Theodoros N</au><au>Zagouri, Flora</au><au>Tzilalis, Basileios</au><au>Mouzakioti, Elena</au><au>Parasi, Aggeliki</au><au>Nonni, Afroditi</au><au>Mariolis, Anargiros</au><au>Androulakis, George</au><au>Zografos, George C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>22</volume><issue>2</issue><spage>269</spage><epage>272</epage><pages>269-272</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Backround: The present study focused on cholecystectomized elderly patients and aimed to investigate whether inflammation
in the gallbladder wall was associated with the number and size of gallstones, as well as the patients' age. Patients and
Methods: The present study included 306 cholecystectomized patients aged over 65 years. From the specimens derived from cholecystectomy,
the gallstone number, the largest gallstone diameter and gallbladder wall thickness were determined. According to the histopathological
examination, chronic inflammation was subdivided into mild-moderate and severe. Univariable analysis and multivariable logistic
regression followed. Results: Mild-moderate inflammation characterized 63.4% of the cases and severe inflammation 36.6%. Solitary
gallstones were found in 13.1% of the cases, while multiple gallstones were found in 86.9% of the cases. The largest gallstone
diameter was less than 1 cm in the majority of cases (73.2%). The gallbladder wall thickness was associated with the degree
of inflammation (p<0.001, Chi-square). In the univariable analysis, inflammation was positively associated with the diameter
of the largest gallstone (p=0.032, Chi-square), but negatively associated with the number of gallstones (p<0.001, Chi-square)
and patients< age (p=0.008, logistic regression). The number of gallstones was negatively associated with the diameter of
gallstones and positively associated with the patients< age. The diameter of the largest gallstone was negatively associated
with the patients< age. In the multivariable logistic regression, the effect of age (OR=0.95, 95% CI: 0.91-0.99) and solitary
gallstones (OR=2.66, 95% CI: 1.02-6.93) on inflammation persisted, but that of the largest gallstone diameter vanished. Conclusion:
The elderly population presented mainly with multiple and small gallstones. Solitary gallstones and younger age were the most
important predictors for severe inflammation.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>18468414</pmid><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Cholecystitis - pathology Chronic Disease Female Gallbladder - pathology Gallstones - pathology Humans Inflammation - immunology Male Severity of Illness Index |
| title | Chronic Cholecystitis in Elderly Patients. Correlation of the Severity of Inflammation with the Number and Size of the Stones |
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