Input synchrony and the irregular firing of cortical neurons
Cortical neurons in the waking brain fire highly irregular, seemingly random, spike trains in response to constant sensory stimulation, whereas in vitro they fire regularly in response to constant current injection. To test whether, as has been suggested, this high in vivo variability could be due t...
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| Veröffentlicht in: | Nature neuroscience 1998-07, Vol.1 (3), p.210-217 |
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| creator | Zador, Anthony M Stevens, Charles F |
| description | Cortical neurons in the waking brain fire highly irregular, seemingly random, spike trains in response to constant sensory stimulation, whereas
in vitro
they fire regularly in response to constant current injection. To test whether, as has been suggested, this high
in vivo
variability could be due to the postsynaptic currents generated by independent synaptic inputs, we injected synthetic synaptic current into neocortical neurons in brain slices. We report that independent inputs cannot account for this high variability, but this variability can be explained by a simple alternative model of the synaptic drive in which inputs arrive synchronously. Our results suggest that synchrony may be important in the neural code by providing a means for encoding signals with high temporal fidelity over a population of neurons. |
| doi_str_mv | 10.1038/659 |
| format | Article |
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in vivo
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in vitro
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in vivo
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in vitro
they fire regularly in response to constant current injection. To test whether, as has been suggested, this high
in vivo
variability could be due to the postsynaptic currents generated by independent synaptic inputs, we injected synthetic synaptic current into neocortical neurons in brain slices. We report that independent inputs cannot account for this high variability, but this variability can be explained by a simple alternative model of the synaptic drive in which inputs arrive synchronously. Our results suggest that synchrony may be important in the neural code by providing a means for encoding signals with high temporal fidelity over a population of neurons.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>10195145</pmid><doi>10.1038/659</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nature neuroscience, 1998-07, Vol.1 (3), p.210-217 |
| issn | 1097-6256 1546-1726 |
| language | eng |
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Action Potentials - physiology Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cerebral Cortex - cytology Cerebral Cortex - physiology Electric Stimulation Excitatory Postsynaptic Potentials - physiology In Vitro Techniques Models, Neurological Neural Inhibition - physiology Neurobiology Neurons - physiology Neurosciences Patch-Clamp Techniques Rats Rats, Long-Evans Synapses - physiology Time Factors |
| title | Input synchrony and the irregular firing of cortical neurons |
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