Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement
An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly,...
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| Veröffentlicht in: | Endocrine Journal 2008, Vol.55(2), pp.425-428 |
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| container_title | Endocrine Journal |
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| creator | MARUYAMA, Hiroshi IWASAKI, Yasumasa TSUGITA, Makoto OGAMI, Naoko ASABA, Koichi TAKAO, Toshihiro NAKABAYASHI, Hiromichi SHIMIZU, Keiji HASHIMOTO, Kozo |
| description | An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration. |
| doi_str_mv | 10.1507/endocrj.K07E-070 |
| format | Article |
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Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.K07E-070</identifier><identifier>PMID: 18385528</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Aged, 80 and over ; Central Nervous System Cysts - drug therapy ; Central Nervous System Cysts - pathology ; Central Nervous System Cysts - surgery ; Dose-Response Relationship, Drug ; Glucocorticoid ; Glucocorticoids - therapeutic use ; Humans ; Hydrocortisone - therapeutic use ; Hypopituitarism ; Magnetic Resonance Imaging ; Male ; Pituitary tumor ; Rathke's cleft cyst</subject><ispartof>Endocrine Journal, 2008, Vol.55(2), pp.425-428</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-98994f44ab1e430af622053f761b5be4ad786e5273808d3edae90b4b0dbb49c33</citedby><cites>FETCH-LOGICAL-c492t-98994f44ab1e430af622053f761b5be4ad786e5273808d3edae90b4b0dbb49c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18385528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARUYAMA, Hiroshi</creatorcontrib><creatorcontrib>IWASAKI, Yasumasa</creatorcontrib><creatorcontrib>TSUGITA, Makoto</creatorcontrib><creatorcontrib>OGAMI, Naoko</creatorcontrib><creatorcontrib>ASABA, Koichi</creatorcontrib><creatorcontrib>TAKAO, Toshihiro</creatorcontrib><creatorcontrib>NAKABAYASHI, Hiromichi</creatorcontrib><creatorcontrib>SHIMIZU, Keiji</creatorcontrib><creatorcontrib>HASHIMOTO, Kozo</creatorcontrib><title>Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement</title><title>Endocrine Journal</title><addtitle>Endocr J</addtitle><description>An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration.</description><subject>Aged, 80 and over</subject><subject>Central Nervous System Cysts - drug therapy</subject><subject>Central Nervous System Cysts - pathology</subject><subject>Central Nervous System Cysts - surgery</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glucocorticoid</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Hydrocortisone - therapeutic use</subject><subject>Hypopituitarism</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Pituitary tumor</subject><subject>Rathke's cleft cyst</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1v2zAQQImiQeMk3TsVnNpJzlEkLXIsBDspaiBAPpYsBEWdIrmS6JI0iuTXR4Zdd7kb7t0bHiFfGMyZhOIax9q7sJn_gmKZQQEfyIxxoTIhBXwkM9BMZUpLfU4uYtwAcC4F_0TOmeJKylzNyPO9Te1v_B5p2WOTaPkaE_3bpZY-tD6k7BHDQB-6N6Rla8cXjLQb6T3GrR8j0uTpTb9z3k1o53xXT6dtbx0OOKYrctbYPuLn474kT6vlY3mbre9ufpY_1pkTOk-ZVlqLRghbMRQcbLPIc5C8KRaskhUKWxdqgTIvuAJVc6wtaqhEBXVVCe04vyTfDt5t8H92GJMZuuiw7-2IfhfNQjMtuIAJhAPogo8xYGO2oRtseDUMzL6nOfY0-55m6jm9fD26d9WA9f-HY8AJWB2ATUz2BU-A3Qfp8WSU0uT78c98Alxrw0Txd9t9jKM</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>MARUYAMA, Hiroshi</creator><creator>IWASAKI, Yasumasa</creator><creator>TSUGITA, Makoto</creator><creator>OGAMI, Naoko</creator><creator>ASABA, Koichi</creator><creator>TAKAO, Toshihiro</creator><creator>NAKABAYASHI, Hiromichi</creator><creator>SHIMIZU, Keiji</creator><creator>HASHIMOTO, Kozo</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement</title><author>MARUYAMA, Hiroshi ; IWASAKI, Yasumasa ; TSUGITA, Makoto ; OGAMI, Naoko ; ASABA, Koichi ; TAKAO, Toshihiro ; NAKABAYASHI, Hiromichi ; SHIMIZU, Keiji ; HASHIMOTO, Kozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-98994f44ab1e430af622053f761b5be4ad786e5273808d3edae90b4b0dbb49c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged, 80 and over</topic><topic>Central Nervous System Cysts - drug therapy</topic><topic>Central Nervous System Cysts - pathology</topic><topic>Central Nervous System Cysts - surgery</topic><topic>Dose-Response Relationship, Drug</topic><topic>Glucocorticoid</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Hydrocortisone - therapeutic use</topic><topic>Hypopituitarism</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Pituitary tumor</topic><topic>Rathke's cleft cyst</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARUYAMA, Hiroshi</creatorcontrib><creatorcontrib>IWASAKI, Yasumasa</creatorcontrib><creatorcontrib>TSUGITA, Makoto</creatorcontrib><creatorcontrib>OGAMI, Naoko</creatorcontrib><creatorcontrib>ASABA, Koichi</creatorcontrib><creatorcontrib>TAKAO, Toshihiro</creatorcontrib><creatorcontrib>NAKABAYASHI, Hiromichi</creatorcontrib><creatorcontrib>SHIMIZU, Keiji</creatorcontrib><creatorcontrib>HASHIMOTO, Kozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARUYAMA, Hiroshi</au><au>IWASAKI, Yasumasa</au><au>TSUGITA, Makoto</au><au>OGAMI, Naoko</au><au>ASABA, Koichi</au><au>TAKAO, Toshihiro</au><au>NAKABAYASHI, Hiromichi</au><au>SHIMIZU, Keiji</au><au>HASHIMOTO, Kozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement</atitle><jtitle>Endocrine Journal</jtitle><addtitle>Endocr J</addtitle><date>2008</date><risdate>2008</risdate><volume>55</volume><issue>2</issue><spage>425</spage><epage>428</epage><pages>425-428</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>An 81-year-old man was admitted to our hospital because of general fatigue. Hormonal examination showed that he had panhypopituitarism and central diabetes insipidus. MRI imaging revealed the presence of large cystic mass with suprasellar extension in his hypothalamo-pituitary region. Interestingly, the cystic mass shrank following the start of glucocorticoid replacement, and since then relatively high doses of cortisol administration were needed to prevent the re-enlargement of cystic size. Because of the concern over possible side effects of supraphysiological doses of glucocorticoid replacement, surgical treatment was eventually carried out, confirming the pathological feature of Rathke's cleft cyst. The present case suggests that the inflammatory nature of Rathke's cleft cyst may explain the observed short-term size changes in response to glucocorticoid administration.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>18385528</pmid><doi>10.1507/endocrj.K07E-070</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged, 80 and over Central Nervous System Cysts - drug therapy Central Nervous System Cysts - pathology Central Nervous System Cysts - surgery Dose-Response Relationship, Drug Glucocorticoid Glucocorticoids - therapeutic use Humans Hydrocortisone - therapeutic use Hypopituitarism Magnetic Resonance Imaging Male Pituitary tumor Rathke's cleft cyst |
| title | Rathke's Cleft Cyst with Short-Term Size Changes in Response to Glucocorticoid Replacement |
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