Dopaminergic regulation of cerebral cortical microcirculation
Functional variations in cerebral cortical activity are accompanied by local changes in blood flow, but the mechanisms underlying this physiological coupling are not well understood. Here we report that dopamine, a neurotransmitter normally associated with neuromodulatory actions, may directly affec...
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| Veröffentlicht in: | Nature neuroscience 1998-08, Vol.1 (4), p.286-289 |
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| container_title | Nature neuroscience |
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| creator | Krimer, Leonid S. Muly, E. Christopher Williams, Graham V. Goldman-Rakic, Patricia S. |
| description | Functional variations in cerebral cortical activity are accompanied by local changes in blood flow, but the mechanisms underlying this physiological coupling are not well understood. Here we report that dopamine, a neurotransmitter normally associated with neuromodulatory actions, may directly affect local cortical blood flow. Using light and electron-microscopic immunocytochemistry, we show that dopaminergic axons innervate the intraparenchymal microvessels. We also provide evidence in an
in vitro
slice preparation that dopamine produces vasomotor responses in the cortical vasculature. These anatomical and physiological observations reveal a previously unknown source of regulation of the microvasculature by dopamine. The findings may be relevant to the mechanisms underlying changes in blood flow observed in circulatory and neuropsychiatric disorders. |
| doi_str_mv | 10.1038/1099 |
| format | Article |
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in vitro
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in vitro
slice preparation that dopamine produces vasomotor responses in the cortical vasculature. These anatomical and physiological observations reveal a previously unknown source of regulation of the microvasculature by dopamine. The findings may be relevant to the mechanisms underlying changes in blood flow observed in circulatory and neuropsychiatric disorders.</description><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Vessels - drug effects</subject><subject>Blood Vessels - innervation</subject><subject>Cerebral Cortex - blood supply</subject><subject>Dopamine - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Immunohistochemistry</subject><subject>In Vitro Techniques</subject><subject>Macaca mulatta</subject><subject>Microcirculation - drug effects</subject><subject>Microcirculation - physiology</subject><subject>Microscopy, Electron</subject><subject>Nerve Endings - metabolism</subject><subject>Nerve Endings - ultrastructure</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Vasomotor System - drug effects</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXlL6AMwBbwJbEdDwyofEqVWGCOHOdcuUriYicD_76u0gEmpnt19-iV7iFkCfQOaF7eA5XyhMyBFTwFkfHTmKkUKc8Yn5GLELaUUsFKeU5mQEEy4DAnD09upzrbo99YnXjcjK0arOsTZxKNHmuv2kQ7P1gdQ2e1d9p6faSW5MyoNuDlcS7I18vz5-otXX-8vq8e16kuZD6kBeZIBXA0meZUNco0CgUznBWsNphByQw0rDC54rmSpRJ1XGjR5CBNBjxfkNupd-fd94hhqDobNLat6tGNoeISJDAm_gVBQEaLrIzg9QTGh0LwaKqdt53yPxXQ6uCzOviM2NWxb6w7bH5Bk8AI3ExAiKd-g77autH3Ucbfoj28_HuH</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Krimer, Leonid S.</creator><creator>Muly, E. 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We also provide evidence in an
in vitro
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| ispartof | Nature neuroscience, 1998-08, Vol.1 (4), p.286-289 |
| issn | 1097-6256 1546-1726 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animal Genetics and Genomics Animals Axons - physiology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Blood Vessels - drug effects Blood Vessels - innervation Cerebral Cortex - blood supply Dopamine - pharmacology Dopamine - physiology Immunohistochemistry In Vitro Techniques Macaca mulatta Microcirculation - drug effects Microcirculation - physiology Microscopy, Electron Nerve Endings - metabolism Nerve Endings - ultrastructure Neurobiology Neurosciences Vasomotor System - drug effects |
| title | Dopaminergic regulation of cerebral cortical microcirculation |
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