The impact of target site accessibility on the design of effective siRNAs

Small-interfering RNAs (siRNAs) assemble into RISC, the RNA-induced silencing complex, which cleaves complementary mRNAs. Despite their fluctuating efficacy, siRNAs are widely used to assess gene function. Although this limitation could be ascribed, in part, to variations in the assembly and activat...

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Veröffentlicht in:	Nature biotechnology 2008-05, Vol.26 (5), p.578-583
Hauptverfasser:	Obernosterer, Gregor, Hofacker, Ivo L, Tafer, Hakim, Ameres, Stefan L, Gebeshuber, Christoph A, Schroeder, Renée, Martinez, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Base Sequence Binding Sites Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Calibration Computer Simulation Design Drug Design Evaluation Fundamental and applied biological sciences. Psychology Gene Targeting - methods Genetic engineering Genetic research letter Life Sciences Models, Chemical Models, Genetic Molecular Sequence Data Nucleotides Properties Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics Sequence Analysis, RNA - methods Structure
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