A Convenient Route to N-[2-(Fmoc)aminoethyl]glycine Esters and PNA Oligomerization Using a Bis-N-Boc Nucleobase Protecting Group Strategy

A simple and practical synthesis of the benzyl, allyl, and 4-nitrobenzyl esters of N-[2-(Fmoc)aminoethyl]glycine is described starting from the known N-(2-aminoethyl)glycine. These esters are stored as stable hydrochloride salts and were used in the synthesis of peptide nucleic acid monomers possess...

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Veröffentlicht in:	Journal of organic chemistry 2008-05, Vol.73 (10), p.3807-3816
Hauptverfasser:	Wojciechowski, Filip, Hudson, Robert H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Chemistry Dna, deoxyribonucleoproteins Esters - chemical synthesis Esters - chemistry Exact sciences and technology Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - chemistry Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Molecular Structure Nucleic acids Organic chemistry Peptide Nucleic Acids - chemistry Peptides Preparations and properties Stereoisomerism
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