A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets
A method has been defined to interfacially photopolymerize poly(ethylene glycol) diacrylates (PEG diacrylates) to form a crosslinked hydrogel membrane upon the surfaces of porcine islets of Langerhans to serve as an immune barrier for allo‐ and xenotransplantation. A sensitivity study of six key par...
Gespeichert in:
| Veröffentlicht in: | Biotechnology and bioengineering 1998-03, Vol.57 (6), p.655-665 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 665 |
|---|---|
| container_issue | 6 |
| container_start_page | 655 |
| container_title | Biotechnology and bioengineering |
| container_volume | 57 |
| creator | Cruise, Gregory M. Hegre, Orion D. Scharp, David S. Hubbell, Jeffrey A. |
| description | A method has been defined to interfacially photopolymerize poly(ethylene glycol) diacrylates (PEG diacrylates) to form a crosslinked hydrogel membrane upon the surfaces of porcine islets of Langerhans to serve as an immune barrier for allo‐ and xenotransplantation. A sensitivity study of six key parameters in the interfacial photopolymerization process was performed to aid in determination of the optimal encapsulation conditions, leading to the most uniform hydrogel membranes and viable islets. The key parameters included the concentrations of the components of the initiation scheme, namely eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone. Other parameters investigated included the duration and flux of laser irradiation and the PEG diacrylate molecular weight. Each parameter was doubled and halved from the standard conditions used in the encapsulation process while holding all the remaining parameters at the standard conditions. The effects of changing each parameter on islet viability, encapsulation efficiency, and gel thickness were quantified. Islet viability was sensitive to the duration of laser illumination, viability significantly increasing as the duration was reduced. Encapsulation efficiency was sensitive to the concentrations of eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone, to the laser flux, and to the PEG diacrylate molecular weight. Increasing the concentration of eosin Y significantly improved the encapsulation efficiency, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the encapsulation efficiency. Gel thickness was sensitive to the concentrations of triethanolamine and 1‐vinyl 2‐pyrrolidinone, to the duration of laser illumination, and to the PEG diacrylate molecular weight. Increasing the PEG diacrylate molecular weight significantly increased the gel thickness, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the gel thickness. From this sensitivity study, conditions were determined to encapsulate porcine islets, resulting in greater than 90% islet viability and greater than 90% encapsulation efficiency. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 655–665, 1998 |
| doi_str_mv | 10.1002/(SICI)1097-0290(19980320)57:6<655::AID-BIT3>3.0.CO;2-K |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69189987</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16446968</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5973-8ae347708beb223f81ca58cc704450f9f55bf503ea70c419581cd81ab11edec83</originalsourceid><addsrcrecordid>eNqFkV1v0zAUhiMEYmPwF1AuEGovUvwRx_FAk0qBreq0MjHg8sh1HWbmJsF2gfAL-Nk4a6kmgdSr6NiP3_MqT5KcYDTCCJEXgw_TyXSIkeAZIgINsBAlogQNGT8uXhWMHR-Pp2-y19MrekJHaDSZvyTZ7F5yuHtyPzlECBUZZYIcJI-8_xpHXhbFw-QgrhCC5Oww-T1Ova69Cea7CV3qw3rZpU2Vhmud3ugubaWTKx2086mpb09NHadKKiNt2l43oWkb2620M79kME3dP-5PBjpcd1bXOv1iO9XYYbo0UrnOyqDTdRvBtnHKxHvjrQ7-cfKgktbrJ9vvUfLx3duryVl2Pj-dTsbnmWKC06yUmuaco3KhF4TQqsRKslIpjvKcoUpUjC0qhqiWHKkcCxaBZYnlAmO91KqkR8nzTW7rmm9r7QOsjFfaWlnrZu2hELiM_5rvBQmmGOG4ah-IizwvRNGv_rQBlWu8d7qC1pmVdB1gBL11gN469AqhVwh_rQPjUEC0DhCtQ28dKCCYzIHALAY_3TZYL1Z6eSd2ozkCz7aA9ErayslaGb_jCC4QpncK_jBWd_-021vuP91u5xicbYKND_rnLli6Gyg45Qw-X5zCxSV_T85mGC7pH_Dc5j8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16446968</pqid></control><display><type>article</type><title>A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cruise, Gregory M. ; Hegre, Orion D. ; Scharp, David S. ; Hubbell, Jeffrey A.</creator><creatorcontrib>Cruise, Gregory M. ; Hegre, Orion D. ; Scharp, David S. ; Hubbell, Jeffrey A.</creatorcontrib><description>A method has been defined to interfacially photopolymerize poly(ethylene glycol) diacrylates (PEG diacrylates) to form a crosslinked hydrogel membrane upon the surfaces of porcine islets of Langerhans to serve as an immune barrier for allo‐ and xenotransplantation. A sensitivity study of six key parameters in the interfacial photopolymerization process was performed to aid in determination of the optimal encapsulation conditions, leading to the most uniform hydrogel membranes and viable islets. The key parameters included the concentrations of the components of the initiation scheme, namely eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone. Other parameters investigated included the duration and flux of laser irradiation and the PEG diacrylate molecular weight. Each parameter was doubled and halved from the standard conditions used in the encapsulation process while holding all the remaining parameters at the standard conditions. The effects of changing each parameter on islet viability, encapsulation efficiency, and gel thickness were quantified. Islet viability was sensitive to the duration of laser illumination, viability significantly increasing as the duration was reduced. Encapsulation efficiency was sensitive to the concentrations of eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone, to the laser flux, and to the PEG diacrylate molecular weight. Increasing the concentration of eosin Y significantly improved the encapsulation efficiency, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the encapsulation efficiency. Gel thickness was sensitive to the concentrations of triethanolamine and 1‐vinyl 2‐pyrrolidinone, to the duration of laser illumination, and to the PEG diacrylate molecular weight. Increasing the PEG diacrylate molecular weight significantly increased the gel thickness, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the gel thickness. From this sensitivity study, conditions were determined to encapsulate porcine islets, resulting in greater than 90% islet viability and greater than 90% encapsulation efficiency. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 655–665, 1998</description><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/(SICI)1097-0290(19980320)57:6<655::AID-BIT3>3.0.CO;2-K</identifier><identifier>PMID: 10099245</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Artificial organs ; bioartificial organs ; Biological and medical sciences ; Biotechnology ; Cell Survival ; Composition effects ; Crosslinking ; Drug Compounding ; Encapsulation ; Eosine Yellowish-(YS) - chemistry ; Eosine Yellowish-(YS) - metabolism ; Ethanolamines - chemistry ; Ethidium - chemistry ; Fluoresceins - chemistry ; Fundamental and applied biological sciences. Psychology ; Gels - chemistry ; Health. Pharmaceutical industry ; Hydrogels ; Image Processing, Computer-Assisted ; Industrial applications and implications. Economical aspects ; islets of Langerhans ; Islets of Langerhans - metabolism ; Lasers ; microencapsulation ; Microscopy - methods ; Miscellaneous ; Molecular Weight ; Photochemical reactions ; photopolymerization ; poly(ethylene glycol) ; Polyethylene glycols ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - metabolism ; Polymerization ; Pyrrolidinones - chemistry ; Sensitivity analysis ; Swine</subject><ispartof>Biotechnology and bioengineering, 1998-03, Vol.57 (6), p.655-665</ispartof><rights>Copyright © 1998 John Wiley & Sons, Inc.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 John Wiley & Sons, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5973-8ae347708beb223f81ca58cc704450f9f55bf503ea70c419581cd81ab11edec83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0290%2819980320%2957%3A6%3C655%3A%3AAID-BIT3%3E3.0.CO%3B2-K$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0290%2819980320%2957%3A6%3C655%3A%3AAID-BIT3%3E3.0.CO%3B2-K$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2160138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10099245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruise, Gregory M.</creatorcontrib><creatorcontrib>Hegre, Orion D.</creatorcontrib><creatorcontrib>Scharp, David S.</creatorcontrib><creatorcontrib>Hubbell, Jeffrey A.</creatorcontrib><title>A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>A method has been defined to interfacially photopolymerize poly(ethylene glycol) diacrylates (PEG diacrylates) to form a crosslinked hydrogel membrane upon the surfaces of porcine islets of Langerhans to serve as an immune barrier for allo‐ and xenotransplantation. A sensitivity study of six key parameters in the interfacial photopolymerization process was performed to aid in determination of the optimal encapsulation conditions, leading to the most uniform hydrogel membranes and viable islets. The key parameters included the concentrations of the components of the initiation scheme, namely eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone. Other parameters investigated included the duration and flux of laser irradiation and the PEG diacrylate molecular weight. Each parameter was doubled and halved from the standard conditions used in the encapsulation process while holding all the remaining parameters at the standard conditions. The effects of changing each parameter on islet viability, encapsulation efficiency, and gel thickness were quantified. Islet viability was sensitive to the duration of laser illumination, viability significantly increasing as the duration was reduced. Encapsulation efficiency was sensitive to the concentrations of eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone, to the laser flux, and to the PEG diacrylate molecular weight. Increasing the concentration of eosin Y significantly improved the encapsulation efficiency, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the encapsulation efficiency. Gel thickness was sensitive to the concentrations of triethanolamine and 1‐vinyl 2‐pyrrolidinone, to the duration of laser illumination, and to the PEG diacrylate molecular weight. Increasing the PEG diacrylate molecular weight significantly increased the gel thickness, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the gel thickness. From this sensitivity study, conditions were determined to encapsulate porcine islets, resulting in greater than 90% islet viability and greater than 90% encapsulation efficiency. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 655–665, 1998</description><subject>Animals</subject><subject>Artificial organs</subject><subject>bioartificial organs</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Cell Survival</subject><subject>Composition effects</subject><subject>Crosslinking</subject><subject>Drug Compounding</subject><subject>Encapsulation</subject><subject>Eosine Yellowish-(YS) - chemistry</subject><subject>Eosine Yellowish-(YS) - metabolism</subject><subject>Ethanolamines - chemistry</subject><subject>Ethidium - chemistry</subject><subject>Fluoresceins - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gels - chemistry</subject><subject>Health. Pharmaceutical industry</subject><subject>Hydrogels</subject><subject>Image Processing, Computer-Assisted</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>islets of Langerhans</subject><subject>Islets of Langerhans - metabolism</subject><subject>Lasers</subject><subject>microencapsulation</subject><subject>Microscopy - methods</subject><subject>Miscellaneous</subject><subject>Molecular Weight</subject><subject>Photochemical reactions</subject><subject>photopolymerization</subject><subject>poly(ethylene glycol)</subject><subject>Polyethylene glycols</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - metabolism</subject><subject>Polymerization</subject><subject>Pyrrolidinones - chemistry</subject><subject>Sensitivity analysis</subject><subject>Swine</subject><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAUhiMEYmPwF1AuEGovUvwRx_FAk0qBreq0MjHg8sh1HWbmJsF2gfAL-Nk4a6kmgdSr6NiP3_MqT5KcYDTCCJEXgw_TyXSIkeAZIgINsBAlogQNGT8uXhWMHR-Pp2-y19MrekJHaDSZvyTZ7F5yuHtyPzlECBUZZYIcJI-8_xpHXhbFw-QgrhCC5Oww-T1Ova69Cea7CV3qw3rZpU2Vhmud3ugubaWTKx2086mpb09NHadKKiNt2l43oWkb2620M79kME3dP-5PBjpcd1bXOv1iO9XYYbo0UrnOyqDTdRvBtnHKxHvjrQ7-cfKgktbrJ9vvUfLx3duryVl2Pj-dTsbnmWKC06yUmuaco3KhF4TQqsRKslIpjvKcoUpUjC0qhqiWHKkcCxaBZYnlAmO91KqkR8nzTW7rmm9r7QOsjFfaWlnrZu2hELiM_5rvBQmmGOG4ah-IizwvRNGv_rQBlWu8d7qC1pmVdB1gBL11gN469AqhVwh_rQPjUEC0DhCtQ28dKCCYzIHALAY_3TZYL1Z6eSd2ozkCz7aA9ErayslaGb_jCC4QpncK_jBWd_-021vuP91u5xicbYKND_rnLli6Gyg45Qw-X5zCxSV_T85mGC7pH_Dc5j8</recordid><startdate>19980320</startdate><enddate>19980320</enddate><creator>Cruise, Gregory M.</creator><creator>Hegre, Orion D.</creator><creator>Scharp, David S.</creator><creator>Hubbell, Jeffrey A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980320</creationdate><title>A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets</title><author>Cruise, Gregory M. ; Hegre, Orion D. ; Scharp, David S. ; Hubbell, Jeffrey A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5973-8ae347708beb223f81ca58cc704450f9f55bf503ea70c419581cd81ab11edec83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Artificial organs</topic><topic>bioartificial organs</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Cell Survival</topic><topic>Composition effects</topic><topic>Crosslinking</topic><topic>Drug Compounding</topic><topic>Encapsulation</topic><topic>Eosine Yellowish-(YS) - chemistry</topic><topic>Eosine Yellowish-(YS) - metabolism</topic><topic>Ethanolamines - chemistry</topic><topic>Ethidium - chemistry</topic><topic>Fluoresceins - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gels - chemistry</topic><topic>Health. Pharmaceutical industry</topic><topic>Hydrogels</topic><topic>Image Processing, Computer-Assisted</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>islets of Langerhans</topic><topic>Islets of Langerhans - metabolism</topic><topic>Lasers</topic><topic>microencapsulation</topic><topic>Microscopy - methods</topic><topic>Miscellaneous</topic><topic>Molecular Weight</topic><topic>Photochemical reactions</topic><topic>photopolymerization</topic><topic>poly(ethylene glycol)</topic><topic>Polyethylene glycols</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - metabolism</topic><topic>Polymerization</topic><topic>Pyrrolidinones - chemistry</topic><topic>Sensitivity analysis</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruise, Gregory M.</creatorcontrib><creatorcontrib>Hegre, Orion D.</creatorcontrib><creatorcontrib>Scharp, David S.</creatorcontrib><creatorcontrib>Hubbell, Jeffrey A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruise, Gregory M.</au><au>Hegre, Orion D.</au><au>Scharp, David S.</au><au>Hubbell, Jeffrey A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>1998-03-20</date><risdate>1998</risdate><volume>57</volume><issue>6</issue><spage>655</spage><epage>665</epage><pages>655-665</pages><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>A method has been defined to interfacially photopolymerize poly(ethylene glycol) diacrylates (PEG diacrylates) to form a crosslinked hydrogel membrane upon the surfaces of porcine islets of Langerhans to serve as an immune barrier for allo‐ and xenotransplantation. A sensitivity study of six key parameters in the interfacial photopolymerization process was performed to aid in determination of the optimal encapsulation conditions, leading to the most uniform hydrogel membranes and viable islets. The key parameters included the concentrations of the components of the initiation scheme, namely eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone. Other parameters investigated included the duration and flux of laser irradiation and the PEG diacrylate molecular weight. Each parameter was doubled and halved from the standard conditions used in the encapsulation process while holding all the remaining parameters at the standard conditions. The effects of changing each parameter on islet viability, encapsulation efficiency, and gel thickness were quantified. Islet viability was sensitive to the duration of laser illumination, viability significantly increasing as the duration was reduced. Encapsulation efficiency was sensitive to the concentrations of eosin Y, triethanolamine, and 1‐vinyl 2‐pyrrolidinone, to the laser flux, and to the PEG diacrylate molecular weight. Increasing the concentration of eosin Y significantly improved the encapsulation efficiency, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the encapsulation efficiency. Gel thickness was sensitive to the concentrations of triethanolamine and 1‐vinyl 2‐pyrrolidinone, to the duration of laser illumination, and to the PEG diacrylate molecular weight. Increasing the PEG diacrylate molecular weight significantly increased the gel thickness, while decreasing the concentration of 1‐vinyl 2‐pyrrolidinone and increasing the concentration of triethanolamine had the greatest effects in significantly reducing the gel thickness. From this sensitivity study, conditions were determined to encapsulate porcine islets, resulting in greater than 90% islet viability and greater than 90% encapsulation efficiency. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 655–665, 1998</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>10099245</pmid><doi>10.1002/(SICI)1097-0290(19980320)57:6<655::AID-BIT3>3.0.CO;2-K</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3592 |
| ispartof | Biotechnology and bioengineering, 1998-03, Vol.57 (6), p.655-665 |
| issn | 0006-3592 1097-0290 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69189987 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Artificial organs bioartificial organs Biological and medical sciences Biotechnology Cell Survival Composition effects Crosslinking Drug Compounding Encapsulation Eosine Yellowish-(YS) - chemistry Eosine Yellowish-(YS) - metabolism Ethanolamines - chemistry Ethidium - chemistry Fluoresceins - chemistry Fundamental and applied biological sciences. Psychology Gels - chemistry Health. Pharmaceutical industry Hydrogels Image Processing, Computer-Assisted Industrial applications and implications. Economical aspects islets of Langerhans Islets of Langerhans - metabolism Lasers microencapsulation Microscopy - methods Miscellaneous Molecular Weight Photochemical reactions photopolymerization poly(ethylene glycol) Polyethylene glycols Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Polymerization Pyrrolidinones - chemistry Sensitivity analysis Swine |
| title | A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T12%3A05%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20sensitivity%20study%20of%20the%20key%20parameters%20in%20the%20interfacial%20photopolymerization%20of%20poly(ethylene%20glycol)%20diacrylate%20upon%20porcine%20islets&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Cruise,%20Gregory%20M.&rft.date=1998-03-20&rft.volume=57&rft.issue=6&rft.spage=655&rft.epage=665&rft.pages=655-665&rft.issn=0006-3592&rft.eissn=1097-0290&rft.coden=BIBIAU&rft_id=info:doi/10.1002/(SICI)1097-0290(19980320)57:6%3C655::AID-BIT3%3E3.0.CO;2-K&rft_dat=%3Cproquest_cross%3E16446968%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16446968&rft_id=info:pmid/10099245&rfr_iscdi=true |