Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic

The pentameric B subunit of verotoxin (VT) mediates the attachment to cell surface globotriaosyl ceramide (Gb3) to facilitate receptor‐mediated endocytosis of the toxin. In highly toxin‐sensitive tumor cells, the holotoxin and VT1 B subunit is targeted intracellularly to elements of the endoplasmic...

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Veröffentlicht in:	Journal of cellular physiology 1998-12, Vol.177 (4), p.646-660
Hauptverfasser:	Arab, Sara, Lingwood, Clifford A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytoma - pathology Bacterial Toxins - chemistry Bacterial Toxins - pharmacology Biological Transport Brain Neoplasms - pathology Butyrates - pharmacology Carcinoma - pathology Drug Resistance, Multiple Drug Resistance, Neoplasm Endocytosis - physiology Endoplasmic Reticulum - metabolism Female Glycolipids - chemistry Glycolipids - metabolism Humans Membrane Lipids - chemistry Membrane Lipids - metabolism Molecular Structure Nuclear Envelope - metabolism Ovarian Neoplasms - pathology Recombinant Fusion Proteins - pharmacology Shiga Toxin 1 Signal Transduction - physiology Sphingolipids - chemistry Sphingolipids - metabolism Tumor Cells, Cultured - drug effects
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