The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis
Objective: Rheumatoid arthritis (RA) is a destructive autoimmune polyarthritis that has been associated with a group of human leucocyte antigen (HLA)-DRB1 alleles that share a common amino-acid sequence at residues 70-74 called the shared epitope (SE). Recently, anti-cyclic citrullinated peptide (CC...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 2008, Vol.37 (3), p.183-187 |
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| creator | Xue, Y. Zhang, J. Chen, Y-M. Guan, M. Zheng, S. G. Zou, H-J. |
| description | Objective: Rheumatoid arthritis (RA) is a destructive autoimmune polyarthritis that has been associated with a group of human leucocyte antigen (HLA)-DRB1 alleles that share a common amino-acid sequence at residues 70-74 called the shared epitope (SE). Recently, anti-cyclic citrullinated peptide (CCP) antibodies have also been reported to be associated with HLA-DR4 and have gained wide acceptance as early diagnostic markers for RA in Caucasian patients. The current study was performed to investigate whether the association between the SE (HLA-DRB1*0401 04 05 10) and anti-CCP antibodies is also present in Chinese Han patients with RA.
Methods: One hundred and four RA patients and 122 healthy controls were recruited. HLA-DR4 was detected by the sequence-specific primer polymerase chain reaction (SSP-PCR) phototyping method. Anti-CCP antibodies and immunoglobulin M rheumatoid factor (IgM-RF) were measured by enzyme-linked immunosorbent assay (ELISA) and laser nephelometry, respectively.
Results: Of the Chinese patients with RA, 76.5% exhibited anti-CCP antibodies compared with none of the controls (76.5% vs. 0%, p |
| doi_str_mv | 10.1080/03009740701874444 |
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Methods: One hundred and four RA patients and 122 healthy controls were recruited. HLA-DR4 was detected by the sequence-specific primer polymerase chain reaction (SSP-PCR) phototyping method. Anti-CCP antibodies and immunoglobulin M rheumatoid factor (IgM-RF) were measured by enzyme-linked immunosorbent assay (ELISA) and laser nephelometry, respectively.
Results: Of the Chinese patients with RA, 76.5% exhibited anti-CCP antibodies compared with none of the controls (76.5% vs. 0%, p<0.001). The prevalence of the SE was significantly higher in patients with RA compared with controls [p = 0.010, odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.16-5.07]. Among the HLA-DR4 alleles, the presence of HLA-DRB1*0401 was significantly higher in RA patients than in controls (p = 0.0118, OR = 9.68, 95% CI = 1.13-448.8). In our study we found that the SE was not associated with production of anti-CCP antibodies (p = 0.2899, OR = 1.920, 95% CI = 0.52-8.89).
Conclusions: The prevalence of the SE is significantly lower in Chinese RA patients, as compared with previous reports of a study using a Caucasian cohort, indicating that distinct genetic risk factors might be associated with anti-CCP antibody production. These data emphasized the complexity of the genetic effects of the major histocompatibility complex on the RA phenotype.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.1080/03009740701874444</identifier><identifier>PMID: 18465452</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Autoantibodies - blood ; Biological and medical sciences ; Case-Control Studies ; China ; Diseases of the osteoarticular system ; Enzyme-Linked Immunosorbent Assay ; Epitopes - genetics ; Epitopes - immunology ; Female ; HLA-DR Antigens - genetics ; HLA-DR4 Antigen - genetics ; HLA-DRB1 Chains ; Humans ; Immunoglobulin M - blood ; Inflammatory joint diseases ; Male ; Medical sciences ; Middle Aged ; Peptides, Cyclic - blood ; Peptides, Cyclic - immunology ; Polymerase Chain Reaction ; Rheumatoid Factor - blood ; Sensitivity and Specificity</subject><ispartof>Scandinavian journal of rheumatology, 2008, Vol.37 (3), p.183-187</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-577fb2ebc4d8f4b17e0583671901d22bde6a5deb5f28a0949d415e533814828d3</citedby><cites>FETCH-LOGICAL-c434t-577fb2ebc4d8f4b17e0583671901d22bde6a5deb5f28a0949d415e533814828d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/03009740701874444$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/03009740701874444$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20329843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18465452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Y.</creatorcontrib><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Chen, Y-M.</creatorcontrib><creatorcontrib>Guan, M.</creatorcontrib><creatorcontrib>Zheng, S. G.</creatorcontrib><creatorcontrib>Zou, H-J.</creatorcontrib><title>The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Objective: Rheumatoid arthritis (RA) is a destructive autoimmune polyarthritis that has been associated with a group of human leucocyte antigen (HLA)-DRB1 alleles that share a common amino-acid sequence at residues 70-74 called the shared epitope (SE). Recently, anti-cyclic citrullinated peptide (CCP) antibodies have also been reported to be associated with HLA-DR4 and have gained wide acceptance as early diagnostic markers for RA in Caucasian patients. The current study was performed to investigate whether the association between the SE (HLA-DRB1*0401 04 05 10) and anti-CCP antibodies is also present in Chinese Han patients with RA.
Methods: One hundred and four RA patients and 122 healthy controls were recruited. HLA-DR4 was detected by the sequence-specific primer polymerase chain reaction (SSP-PCR) phototyping method. Anti-CCP antibodies and immunoglobulin M rheumatoid factor (IgM-RF) were measured by enzyme-linked immunosorbent assay (ELISA) and laser nephelometry, respectively.
Results: Of the Chinese patients with RA, 76.5% exhibited anti-CCP antibodies compared with none of the controls (76.5% vs. 0%, p<0.001). The prevalence of the SE was significantly higher in patients with RA compared with controls [p = 0.010, odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.16-5.07]. Among the HLA-DR4 alleles, the presence of HLA-DRB1*0401 was significantly higher in RA patients than in controls (p = 0.0118, OR = 9.68, 95% CI = 1.13-448.8). In our study we found that the SE was not associated with production of anti-CCP antibodies (p = 0.2899, OR = 1.920, 95% CI = 0.52-8.89).
Conclusions: The prevalence of the SE is significantly lower in Chinese RA patients, as compared with previous reports of a study using a Caucasian cohort, indicating that distinct genetic risk factors might be associated with anti-CCP antibody production. These data emphasized the complexity of the genetic effects of the major histocompatibility complex on the RA phenotype.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Diseases of the osteoarticular system</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epitopes - genetics</subject><subject>Epitopes - immunology</subject><subject>Female</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Immunoglobulin M - blood</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peptides, Cyclic - blood</subject><subject>Peptides, Cyclic - immunology</subject><subject>Polymerase Chain Reaction</subject><subject>Rheumatoid Factor - blood</subject><subject>Sensitivity and Specificity</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6A7xILnprzVd30uhlHT9WGBBkPTfppNrOkknaJM0y_8KfbNYZFRG2LnWo532pqhehp5S8pESRV4QT0ktBJKFKilr30Ia2hDVScnYfbW7nTQXYGXqU8zUhRPSyf4jOqBJdK1q2QT-uZsCXu4vm3Ze3FOdZJ7AYFlfiAthlHGLBOudonC51cuPKjHUobozWQcb6m3YhF2wOxjuDjStp9d6FX_ACS3G22gS8nV2ADHjRxUEo-WiUZlj3ukRnsU5lTq64_Bg9mLTP8OTUz9HXD--vtpfN7vPHT9uLXWMEF6VppZxGBqMRVk1ipBJIq3gnaU-oZWy00OnWwthOTGnSi94K2kLLuaJCMWX5OXpx9F1S_L5CLsPeZQPe6wBxzUPXU9V3SlWQHkGTYs4JpmFJbq_TYaBkuI1h-C-Gqnl2Ml_HPdi_itPfK_D8BOhstJ-SDsblPxwjnPVK8Mq9OXIuTDHt9U1M3g5FH3xMv0X8rj1e_yOfQfsymxrycB3XFOqD77jiJ_qdtqE</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Xue, Y.</creator><creator>Zhang, J.</creator><creator>Chen, Y-M.</creator><creator>Guan, M.</creator><creator>Zheng, S. G.</creator><creator>Zou, H-J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis</title><author>Xue, Y. ; Zhang, J. ; Chen, Y-M. ; Guan, M. ; Zheng, S. G. ; Zou, H-J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-577fb2ebc4d8f4b17e0583671901d22bde6a5deb5f28a0949d415e533814828d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Diseases of the osteoarticular system</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epitopes - genetics</topic><topic>Epitopes - immunology</topic><topic>Female</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Immunoglobulin M - blood</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Peptides, Cyclic - blood</topic><topic>Peptides, Cyclic - immunology</topic><topic>Polymerase Chain Reaction</topic><topic>Rheumatoid Factor - blood</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Y.</creatorcontrib><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Chen, Y-M.</creatorcontrib><creatorcontrib>Guan, M.</creatorcontrib><creatorcontrib>Zheng, S. G.</creatorcontrib><creatorcontrib>Zou, H-J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Y.</au><au>Zhang, J.</au><au>Chen, Y-M.</au><au>Guan, M.</au><au>Zheng, S. G.</au><au>Zou, H-J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>2008</date><risdate>2008</risdate><volume>37</volume><issue>3</issue><spage>183</spage><epage>187</epage><pages>183-187</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Objective: Rheumatoid arthritis (RA) is a destructive autoimmune polyarthritis that has been associated with a group of human leucocyte antigen (HLA)-DRB1 alleles that share a common amino-acid sequence at residues 70-74 called the shared epitope (SE). Recently, anti-cyclic citrullinated peptide (CCP) antibodies have also been reported to be associated with HLA-DR4 and have gained wide acceptance as early diagnostic markers for RA in Caucasian patients. The current study was performed to investigate whether the association between the SE (HLA-DRB1*0401 04 05 10) and anti-CCP antibodies is also present in Chinese Han patients with RA.
Methods: One hundred and four RA patients and 122 healthy controls were recruited. HLA-DR4 was detected by the sequence-specific primer polymerase chain reaction (SSP-PCR) phototyping method. Anti-CCP antibodies and immunoglobulin M rheumatoid factor (IgM-RF) were measured by enzyme-linked immunosorbent assay (ELISA) and laser nephelometry, respectively.
Results: Of the Chinese patients with RA, 76.5% exhibited anti-CCP antibodies compared with none of the controls (76.5% vs. 0%, p<0.001). The prevalence of the SE was significantly higher in patients with RA compared with controls [p = 0.010, odds ratio (OR) = 2.42, 95% confidence interval (CI) = 1.16-5.07]. Among the HLA-DR4 alleles, the presence of HLA-DRB1*0401 was significantly higher in RA patients than in controls (p = 0.0118, OR = 9.68, 95% CI = 1.13-448.8). In our study we found that the SE was not associated with production of anti-CCP antibodies (p = 0.2899, OR = 1.920, 95% CI = 0.52-8.89).
Conclusions: The prevalence of the SE is significantly lower in Chinese RA patients, as compared with previous reports of a study using a Caucasian cohort, indicating that distinct genetic risk factors might be associated with anti-CCP antibody production. These data emphasized the complexity of the genetic effects of the major histocompatibility complex on the RA phenotype.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>18465452</pmid><doi>10.1080/03009740701874444</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Biological and medical sciences Case-Control Studies China Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay Epitopes - genetics Epitopes - immunology Female HLA-DR Antigens - genetics HLA-DR4 Antigen - genetics HLA-DRB1 Chains Humans Immunoglobulin M - blood Inflammatory joint diseases Male Medical sciences Middle Aged Peptides, Cyclic - blood Peptides, Cyclic - immunology Polymerase Chain Reaction Rheumatoid Factor - blood Sensitivity and Specificity |
| title | The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis |
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