Escape of autocrine ligands into extracellular medium: Experimental test of theoretical model predictions

We have developed an experimental system for testing mathematical model predictions concerning escape of autocrine ligands into the extracellular bulk medium. This system employs anti‐receptor blocking antibodies against the epidermal growth factor receptor (EGFR)/transforming growth factor alpha (T...

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Veröffentlicht in:	Biotechnology and bioengineering 1998-03, Vol.57 (5), p.571-582
Hauptverfasser:	Oehrtman, G. T., Wiley, H. S., Lauffenburger, D. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology autocrine Biological and medical sciences Biotechnology cell density Cell Division Cells Cells, Cultured Density (specific gravity) Extracellular Matrix - metabolism Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Humans Mathematical models Mathematics Methods. Procedures. Technologies Mice modeling Models, Biological Modification of gene expression level Plasmids - drug effects Plasmids - genetics Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - immunology Receptor, Epidermal Growth Factor - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Tetracycline - pharmacology TGFα Transfection Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism
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