The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery
To determine the haemodynamic effects of halothane and isoflurane with spontaneous and controlled ventilation in dorsally recumbent horses undergoing elective surgery. Prospective randomized clinical trial. Twenty-five adult horses, body mass 487 kg (range: 267–690). Horses undergoing elective surge...
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| creator | Blissitt, Karen J Raisis, Anthea L Adams, Vicki J Rogers, Katherine H Henley, William E Young, Lesley E |
| description | To determine the haemodynamic effects of halothane and isoflurane with spontaneous and controlled ventilation in dorsally recumbent horses undergoing elective surgery.
Prospective randomized clinical trial.
Twenty-five adult horses, body mass 487 kg (range: 267–690).
Horses undergoing elective surgery in dorsal recumbency were randomly assigned to one of four treatment groups, isoflurane (I) or halothane (H) anaesthesia, each with spontaneous (SB) or controlled ventilation (IPPV). Indices of cardiac function and femoral arterial blood flow (ABF) and resistance were measured using transoesophageal and transcutaneous Doppler echocardiography, respectively. Arterial blood pressure was measured directly.
Four horses assigned to receive isoflurane and spontaneous ventilation (SBI) required IPPV, leaving only three groups for analysis: SBH, IPPVH and IPPVI. Two horses were excluded from the halothane groups because dobutamine was infused to maintain arterial blood pressure. Cardiac index (CI) was significantly greater, and pre-ejection period (PEP) shorter, during isoflurane compared with halothane anaesthesia with both spontaneous (p = 0.04, p = 0.0006, respectively) or controlled ventilation (p = 0.04, p = 0.008, respectively). There was an association between CI and PaCO2 (p = 0.04) such that CI increased by 0.45 L minute−1m−2 for every kPa increase in PaCO2. Femoral ABF was only significantly higher during isoflurane compared with halothane anaesthesia during IPPV (p = 0.0006). There was a significant temporal decrease in CI, but not femoral arterial flow.
The previously reported superior cardiovascular function during isoflurane compared with halothane anaesthesia was maintained in horses undergoing surgery. However, in these clinical subjects, a progressive decrease in CI, which was independent of ventilatory mode, was observed with both anaesthetic agents.
Cardiovascular function may deteriorate progressively in horses anaesthetized for brief ( |
| doi_str_mv | 10.1111/j.1467-2995.2007.00376.x |
| format | Article |
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Prospective randomized clinical trial.
Twenty-five adult horses, body mass 487 kg (range: 267–690).
Horses undergoing elective surgery in dorsal recumbency were randomly assigned to one of four treatment groups, isoflurane (I) or halothane (H) anaesthesia, each with spontaneous (SB) or controlled ventilation (IPPV). Indices of cardiac function and femoral arterial blood flow (ABF) and resistance were measured using transoesophageal and transcutaneous Doppler echocardiography, respectively. Arterial blood pressure was measured directly.
Four horses assigned to receive isoflurane and spontaneous ventilation (SBI) required IPPV, leaving only three groups for analysis: SBH, IPPVH and IPPVI. Two horses were excluded from the halothane groups because dobutamine was infused to maintain arterial blood pressure. Cardiac index (CI) was significantly greater, and pre-ejection period (PEP) shorter, during isoflurane compared with halothane anaesthesia with both spontaneous (p = 0.04, p = 0.0006, respectively) or controlled ventilation (p = 0.04, p = 0.008, respectively). There was an association between CI and PaCO2 (p = 0.04) such that CI increased by 0.45 L minute−1m−2 for every kPa increase in PaCO2. Femoral ABF was only significantly higher during isoflurane compared with halothane anaesthesia during IPPV (p = 0.0006). There was a significant temporal decrease in CI, but not femoral arterial flow.
The previously reported superior cardiovascular function during isoflurane compared with halothane anaesthesia was maintained in horses undergoing surgery. However, in these clinical subjects, a progressive decrease in CI, which was independent of ventilatory mode, was observed with both anaesthetic agents.
Cardiovascular function may deteriorate progressively in horses anaesthetized for brief (<2 hours) surgical procedures in dorsal recumbency. Although cardiovascular function is superior with isoflurane in dorsally recumbent horses, the need for IPPV may be greater.</description><identifier>ISSN: 1467-2987</identifier><identifier>EISSN: 1467-2995</identifier><identifier>DOI: 10.1111/j.1467-2995.2007.00376.x</identifier><identifier>PMID: 18282256</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>adverse effects ; anesthesia ; Anesthesia, Inhalation - veterinary ; Anesthetics, Inhalation - pharmacology ; Animals ; arteries ; blood flow ; Blood Flow Velocity - drug effects ; blood pressure ; Blood Pressure - drug effects ; cardiovascular function ; cardiovascular system ; combination drug therapy ; depth of anesthesia ; drug evaluation ; drug interactions ; echocardiography ; equine anaesthesia ; Female ; haemodynamic monitoring ; halothane ; Halothane - pharmacology ; Heart Rate - drug effects ; Horses ; isoflurane ; Isoflurane - pharmacology ; Male ; pharmacokinetics ; Respiration - drug effects ; respiratory physiology ; surgery ; Time Factors ; transoesophageal Doppler echocardiography ; veterinary drugs</subject><ispartof>Veterinary anaesthesia and analgesia, 2008-05, Vol.35 (3), p.208-219</ispartof><rights>2008 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia</rights><rights>2008 The Authors. Journal compilation © 2008 Association of Veterinary Anaesthetists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4876-4fa540f7ed646fb43095da169e4ef079d427b02a5ba881b81f28045887953293</citedby><cites>FETCH-LOGICAL-c4876-4fa540f7ed646fb43095da169e4ef079d427b02a5ba881b81f28045887953293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1467-2995.2007.00376.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1467-2995.2007.00376.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18282256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blissitt, Karen J</creatorcontrib><creatorcontrib>Raisis, Anthea L</creatorcontrib><creatorcontrib>Adams, Vicki J</creatorcontrib><creatorcontrib>Rogers, Katherine H</creatorcontrib><creatorcontrib>Henley, William E</creatorcontrib><creatorcontrib>Young, Lesley E</creatorcontrib><title>The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery</title><title>Veterinary anaesthesia and analgesia</title><addtitle>Vet Anaesth Analg</addtitle><description>To determine the haemodynamic effects of halothane and isoflurane with spontaneous and controlled ventilation in dorsally recumbent horses undergoing elective surgery.
Prospective randomized clinical trial.
Twenty-five adult horses, body mass 487 kg (range: 267–690).
Horses undergoing elective surgery in dorsal recumbency were randomly assigned to one of four treatment groups, isoflurane (I) or halothane (H) anaesthesia, each with spontaneous (SB) or controlled ventilation (IPPV). Indices of cardiac function and femoral arterial blood flow (ABF) and resistance were measured using transoesophageal and transcutaneous Doppler echocardiography, respectively. Arterial blood pressure was measured directly.
Four horses assigned to receive isoflurane and spontaneous ventilation (SBI) required IPPV, leaving only three groups for analysis: SBH, IPPVH and IPPVI. Two horses were excluded from the halothane groups because dobutamine was infused to maintain arterial blood pressure. Cardiac index (CI) was significantly greater, and pre-ejection period (PEP) shorter, during isoflurane compared with halothane anaesthesia with both spontaneous (p = 0.04, p = 0.0006, respectively) or controlled ventilation (p = 0.04, p = 0.008, respectively). There was an association between CI and PaCO2 (p = 0.04) such that CI increased by 0.45 L minute−1m−2 for every kPa increase in PaCO2. Femoral ABF was only significantly higher during isoflurane compared with halothane anaesthesia during IPPV (p = 0.0006). There was a significant temporal decrease in CI, but not femoral arterial flow.
The previously reported superior cardiovascular function during isoflurane compared with halothane anaesthesia was maintained in horses undergoing surgery. However, in these clinical subjects, a progressive decrease in CI, which was independent of ventilatory mode, was observed with both anaesthetic agents.
Cardiovascular function may deteriorate progressively in horses anaesthetized for brief (<2 hours) surgical procedures in dorsal recumbency. Although cardiovascular function is superior with isoflurane in dorsally recumbent horses, the need for IPPV may be greater.</description><subject>adverse effects</subject><subject>anesthesia</subject><subject>Anesthesia, Inhalation - veterinary</subject><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Animals</subject><subject>arteries</subject><subject>blood flow</subject><subject>Blood Flow Velocity - drug effects</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>cardiovascular function</subject><subject>cardiovascular system</subject><subject>combination drug therapy</subject><subject>depth of anesthesia</subject><subject>drug evaluation</subject><subject>drug interactions</subject><subject>echocardiography</subject><subject>equine anaesthesia</subject><subject>Female</subject><subject>haemodynamic monitoring</subject><subject>halothane</subject><subject>Halothane - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Horses</subject><subject>isoflurane</subject><subject>Isoflurane - pharmacology</subject><subject>Male</subject><subject>pharmacokinetics</subject><subject>Respiration - drug effects</subject><subject>respiratory physiology</subject><subject>surgery</subject><subject>Time Factors</subject><subject>transoesophageal Doppler echocardiography</subject><subject>veterinary drugs</subject><issn>1467-2987</issn><issn>1467-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhSMEYn7gFcArdim248SOxKYzgg5SKRpRYGk59nXrksaDnQzt2-OQqizBG19fn3Ot8znLEMEzktbb3Yywiue0rssZxZjPMC54NTs8yS7PF0_PteAX2VWMO4wJr0v8PLsgggpKy-oyC-stILAWdB-Rt2irWt9vVQdIdQa56G07hPHoO6RVMM4_qqiHVgVkh073LvVdh4wPUbXtEQXQw76Brkfb1IKIhs5A2HjXbVAcwgbC8UX2zKo2wsvTfp2tP7xf397ly8-Lj7fzZa6Z4FXOrCoZthxMxSrbsALXpVGkqoGBxbw2jPIGU1U2SgjSCGKpwKwUImUsaF1cZ2-msQ_B_xwg9nLvooa2TWn8EGVVk6TlZRKKSaiDjzGAlQ_B7VU4SoLliFvu5EhSjlTliFv-wS0Pyfrq9MbQ7MH8NZ74JsG7SfDLtXD878Hy23yeimTPJ7uLPRzOdhV-yIoXvJTfVwt5v_i0vF-tbuQY5fWkt8pLtQkuyq9fKCYFxkIUjIxUbiYFJPKPDoKM2kGnwbj0db003v079m_2572S</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Blissitt, Karen J</creator><creator>Raisis, Anthea L</creator><creator>Adams, Vicki J</creator><creator>Rogers, Katherine H</creator><creator>Henley, William E</creator><creator>Young, Lesley E</creator><general>Elsevier Ltd</general><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery</title><author>Blissitt, Karen J ; Raisis, Anthea L ; Adams, Vicki J ; Rogers, Katherine H ; Henley, William E ; Young, Lesley E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4876-4fa540f7ed646fb43095da169e4ef079d427b02a5ba881b81f28045887953293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adverse effects</topic><topic>anesthesia</topic><topic>Anesthesia, Inhalation - veterinary</topic><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Animals</topic><topic>arteries</topic><topic>blood flow</topic><topic>Blood Flow Velocity - drug effects</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>cardiovascular function</topic><topic>cardiovascular system</topic><topic>combination drug therapy</topic><topic>depth of anesthesia</topic><topic>drug evaluation</topic><topic>drug interactions</topic><topic>echocardiography</topic><topic>equine anaesthesia</topic><topic>Female</topic><topic>haemodynamic monitoring</topic><topic>halothane</topic><topic>Halothane - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Horses</topic><topic>isoflurane</topic><topic>Isoflurane - pharmacology</topic><topic>Male</topic><topic>pharmacokinetics</topic><topic>Respiration - drug effects</topic><topic>respiratory physiology</topic><topic>surgery</topic><topic>Time Factors</topic><topic>transoesophageal Doppler echocardiography</topic><topic>veterinary drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blissitt, Karen J</creatorcontrib><creatorcontrib>Raisis, Anthea L</creatorcontrib><creatorcontrib>Adams, Vicki J</creatorcontrib><creatorcontrib>Rogers, Katherine H</creatorcontrib><creatorcontrib>Henley, William E</creatorcontrib><creatorcontrib>Young, Lesley E</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary anaesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blissitt, Karen J</au><au>Raisis, Anthea L</au><au>Adams, Vicki J</au><au>Rogers, Katherine H</au><au>Henley, William E</au><au>Young, Lesley E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery</atitle><jtitle>Veterinary anaesthesia and analgesia</jtitle><addtitle>Vet Anaesth Analg</addtitle><date>2008-05</date><risdate>2008</risdate><volume>35</volume><issue>3</issue><spage>208</spage><epage>219</epage><pages>208-219</pages><issn>1467-2987</issn><eissn>1467-2995</eissn><abstract>To determine the haemodynamic effects of halothane and isoflurane with spontaneous and controlled ventilation in dorsally recumbent horses undergoing elective surgery.
Prospective randomized clinical trial.
Twenty-five adult horses, body mass 487 kg (range: 267–690).
Horses undergoing elective surgery in dorsal recumbency were randomly assigned to one of four treatment groups, isoflurane (I) or halothane (H) anaesthesia, each with spontaneous (SB) or controlled ventilation (IPPV). Indices of cardiac function and femoral arterial blood flow (ABF) and resistance were measured using transoesophageal and transcutaneous Doppler echocardiography, respectively. Arterial blood pressure was measured directly.
Four horses assigned to receive isoflurane and spontaneous ventilation (SBI) required IPPV, leaving only three groups for analysis: SBH, IPPVH and IPPVI. Two horses were excluded from the halothane groups because dobutamine was infused to maintain arterial blood pressure. Cardiac index (CI) was significantly greater, and pre-ejection period (PEP) shorter, during isoflurane compared with halothane anaesthesia with both spontaneous (p = 0.04, p = 0.0006, respectively) or controlled ventilation (p = 0.04, p = 0.008, respectively). There was an association between CI and PaCO2 (p = 0.04) such that CI increased by 0.45 L minute−1m−2 for every kPa increase in PaCO2. Femoral ABF was only significantly higher during isoflurane compared with halothane anaesthesia during IPPV (p = 0.0006). There was a significant temporal decrease in CI, but not femoral arterial flow.
The previously reported superior cardiovascular function during isoflurane compared with halothane anaesthesia was maintained in horses undergoing surgery. However, in these clinical subjects, a progressive decrease in CI, which was independent of ventilatory mode, was observed with both anaesthetic agents.
Cardiovascular function may deteriorate progressively in horses anaesthetized for brief (<2 hours) surgical procedures in dorsal recumbency. Although cardiovascular function is superior with isoflurane in dorsally recumbent horses, the need for IPPV may be greater.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>18282256</pmid><doi>10.1111/j.1467-2995.2007.00376.x</doi><tpages>12</tpages></addata></record> |
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| subjects | adverse effects anesthesia Anesthesia, Inhalation - veterinary Anesthetics, Inhalation - pharmacology Animals arteries blood flow Blood Flow Velocity - drug effects blood pressure Blood Pressure - drug effects cardiovascular function cardiovascular system combination drug therapy depth of anesthesia drug evaluation drug interactions echocardiography equine anaesthesia Female haemodynamic monitoring halothane Halothane - pharmacology Heart Rate - drug effects Horses isoflurane Isoflurane - pharmacology Male pharmacokinetics Respiration - drug effects respiratory physiology surgery Time Factors transoesophageal Doppler echocardiography veterinary drugs |
| title | The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery |
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