Characterization of Folate Transport Mediated by a Low pH Route in Mouse L1210 Leukemia Cells with Defective Reduced Folate Carrier Function

Folate influx at low pH was characterized in MTX rA cells, an L1210 mouse leukemia cell line with a functional defect in the reduced folate carrier. Folic acid influx in MTX rA cells was negligible at pH 7.5, increased 13-fold as the pH was decreased to 6.0, and was indistinguishable from that in L1...

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Veröffentlicht in:	Biochemical pharmacology 1998-05, Vol.55 (9), p.1505-1512
Hauptverfasser:	Sierra, Esteban E, Goldman, I.David
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid - pharmacology Ammonium Chloride - pharmacology Animals Antineoplastic agents Biological and medical sciences Biological Transport - drug effects Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Cell physiology folate Folate Receptors, GPI-Anchored Folic Acid - metabolism Folic Acid Antagonists - pharmacokinetics Fundamental and applied biological sciences. Psychology General aspects Hydrogen-Ion Concentration Kinetics Leukemia L1210 - metabolism Medical sciences Membrane and intracellular transports methotrexate Methotrexate - pharmacokinetics Mice Molecular and cellular biology Monensin - pharmacology Nigericin - pharmacology Pharmacology. Drug treatments Receptors, Cell Surface reduced folate carrier transport Tumor Cells, Cultured Valinomycin - pharmacology
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