Inclusion of the viral anti-apoptotic molecule M11L in DNA vaccine vectors enhances HIV Env-specific T cell-mediated immunity

Abstract A current goal of vaccine development against human immunodeficiency virus (HIV) is to develop a strategy that stimulates long-lasting memory T-cell responses, and provides immediate cytotoxicity in response to viral challenge. We demonstrate that the viral antiapoptotic molecule M11L promo...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-05, Vol.375 (1), p.48-58
Hauptverfasser:	Su, Jin, Willert, Christy, Comanita, Lacrimioara, Peters, Andrew, Gilbert, Philippe-Alexandre, Strathdee, Craig, O'Connell, Peta J, McFadden, Grant D, Dekaban, Gregory A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS Vaccines - genetics AIDS Vaccines - immunology Animals Apoptosis CD8-Positive T-Lymphocytes - immunology Cell-medicated immunity Cytotoxic T cells DNA vaccination env Gene Products, Human Immunodeficiency Virus - genetics env Gene Products, Human Immunodeficiency Virus - immunology Flow Cytometry Hepatitis C virus HIV HIV Infections - immunology HIV Infections - prevention & control Human immunodeficiency virus Immunization, Secondary Immunogenicity Immunologic Memory Infectious Disease Male Mice Mice, Inbred BALB C Myxoma virus T-Lymphocyte Subsets - immunology Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Proteins - genetics Viral Proteins - immunology
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