HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein

Selective inactivation of critical cysteine residues in human immunodeficiency virus type one (HIV-1) was observed after treatment with 4-vinylpyridine (4-VP), with and without the membrane-permeable metal chelator N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN). Chromatographic...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-05, Vol.375 (1), p.148-158
Hauptverfasser:	Morcock, David R, Thomas, James A, Sowder, 2nd, Raymond C, Henderson, Louis E, Crise, Bruce J, Gorelick, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Cell Line Ethylenediamines - metabolism HIV-1 - drug effects Humans Nucleocapsid Proteins - metabolism Pyridines - pharmacology Virus Inactivation Zinc - metabolism
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