Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method

An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 μm assembled hollow metal microneedle arrays, 300 μm solid metal microneedle arrays and 245 μm hollow silicon microneedle...

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Veröffentlicht in:	Journal of controlled release 2008-05, Vol.128 (1), p.80-88
Hauptverfasser:	Verbaan, F.J., Bal, S.M., van den Berg, D.J., Dijksman, J.A., van Hecke, M., Verpoorten, H., van den Berg, A., Luttge, R., Bouwstra, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Electric applicator Fluorescein-5-isothiocyanate - administration & dosage Fluorescent Dyes - administration & dosage General pharmacology Human skin Humans In vitro transport Injections, Subcutaneous - instrumentation Injections, Subcutaneous - methods Medical sciences Microinjections - instrumentation Microinjections - methods Microneedles Nanoparticles - administration & dosage Needles Organometallic Compounds - administration & dosage Organophosphorus Compounds - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin
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