Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method
An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 μm assembled hollow metal microneedle arrays, 300 μm solid metal microneedle arrays and 245 μm hollow silicon microneedle...
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| Veröffentlicht in: | Journal of controlled release 2008-05, Vol.128 (1), p.80-88 |
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| creator | Verbaan, F.J. Bal, S.M. van den Berg, D.J. Dijksman, J.A. van Hecke, M. Verpoorten, H. van den Berg, A. Luttge, R. Bouwstra, J.A. |
| description | An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 μm assembled hollow metal microneedle arrays, 300 μm solid metal microneedle arrays and 245 μm hollow silicon microneedle arrays. The latter are available as 4
×
4, 6
×
6 and 9
×
9 arrays.
When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4
×
4, 6
×
6 and 9
×
9 hollow silicon microneedle arrays. |
| doi_str_mv | 10.1016/j.jconrel.2008.02.009 |
| format | Article |
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×
4, 6
×
6 and 9
×
9 arrays.
When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4
×
4, 6
×
6 and 9
×
9 hollow silicon microneedle arrays.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2008.02.009</identifier><identifier>PMID: 18394741</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Chromatography, High Pressure Liquid ; Electric applicator ; Fluorescein-5-isothiocyanate - administration & dosage ; Fluorescent Dyes - administration & dosage ; General pharmacology ; Human skin ; Humans ; In vitro transport ; Injections, Subcutaneous - instrumentation ; Injections, Subcutaneous - methods ; Medical sciences ; Microinjections - instrumentation ; Microinjections - methods ; Microneedles ; Nanoparticles - administration & dosage ; Needles ; Organometallic Compounds - administration & dosage ; Organophosphorus Compounds - administration & dosage ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Skin</subject><ispartof>Journal of controlled release, 2008-05, Vol.128 (1), p.80-88</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-825085aa0a8dfb2b20f27171f0b6db8cf9074b208276c5d50b5d3bf36518d4a43</citedby><cites>FETCH-LOGICAL-c537t-825085aa0a8dfb2b20f27171f0b6db8cf9074b208276c5d50b5d3bf36518d4a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365908001004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20343947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18394741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verbaan, F.J.</creatorcontrib><creatorcontrib>Bal, S.M.</creatorcontrib><creatorcontrib>van den Berg, D.J.</creatorcontrib><creatorcontrib>Dijksman, J.A.</creatorcontrib><creatorcontrib>van Hecke, M.</creatorcontrib><creatorcontrib>Verpoorten, H.</creatorcontrib><creatorcontrib>van den Berg, A.</creatorcontrib><creatorcontrib>Luttge, R.</creatorcontrib><creatorcontrib>Bouwstra, J.A.</creatorcontrib><title>Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 μm assembled hollow metal microneedle arrays, 300 μm solid metal microneedle arrays and 245 μm hollow silicon microneedle arrays. The latter are available as 4
×
4, 6
×
6 and 9
×
9 arrays.
When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4
×
4, 6
×
6 and 9
×
9 hollow silicon microneedle arrays.</description><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Electric applicator</subject><subject>Fluorescein-5-isothiocyanate - administration & dosage</subject><subject>Fluorescent Dyes - administration & dosage</subject><subject>General pharmacology</subject><subject>Human skin</subject><subject>Humans</subject><subject>In vitro transport</subject><subject>Injections, Subcutaneous - instrumentation</subject><subject>Injections, Subcutaneous - methods</subject><subject>Medical sciences</subject><subject>Microinjections - instrumentation</subject><subject>Microinjections - methods</subject><subject>Microneedles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Needles</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organophosphorus Compounds - administration & dosage</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Skin</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2PFCEQhonRuOPqT9Bw0Vu3BQ3d9MmYjR-bbOJFrxIaCpexG0bo2WT-vUymo8c9QSpPQdX7EPKaQcuA9e_37d6mmHFuOYBqgbcA4xOyY2roGjGO8inZVU41XS_HK_KilD0AyE4Mz8kVU90oBsF25OftcsjpAR09BMw2xF80eboEm1NEdDNSk7M5FRoidZgXs6alwvfHxURaftfqdKL1GpaDsWulCuY1pEgXXO-Te0meeTMXfLWd1-TH50_fb742d9--3N58vGus7Ia1UVyCksaAUc5PfOLg-cAG5mHq3aSsH2EQtar40FvpJEzSdZOvqzHlhBHdNXl3ebcu8-eIZdVLKBbn2URMx6L7kSkhgD0KcgYCVC8rKC9gTaKUjF4fclhMPmkG-mxA7_VmQJ8NaOC6Gqh9b7YPjlNN6n_XFnkF3m6AKdbMPptoQ_nHcejEmazchwuHNbeHKkcXGzBadCGjXbVL4ZFR_gJZR6d2</recordid><startdate>20080522</startdate><enddate>20080522</enddate><creator>Verbaan, F.J.</creator><creator>Bal, S.M.</creator><creator>van den Berg, D.J.</creator><creator>Dijksman, J.A.</creator><creator>van Hecke, M.</creator><creator>Verpoorten, H.</creator><creator>van den Berg, A.</creator><creator>Luttge, R.</creator><creator>Bouwstra, J.A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080522</creationdate><title>Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method</title><author>Verbaan, F.J. ; Bal, S.M. ; van den Berg, D.J. ; Dijksman, J.A. ; van Hecke, M. ; Verpoorten, H. ; van den Berg, A. ; Luttge, R. ; Bouwstra, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-825085aa0a8dfb2b20f27171f0b6db8cf9074b208276c5d50b5d3bf36518d4a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Electric applicator</topic><topic>Fluorescein-5-isothiocyanate - administration & dosage</topic><topic>Fluorescent Dyes - administration & dosage</topic><topic>General pharmacology</topic><topic>Human skin</topic><topic>Humans</topic><topic>In vitro transport</topic><topic>Injections, Subcutaneous - instrumentation</topic><topic>Injections, Subcutaneous - methods</topic><topic>Medical sciences</topic><topic>Microinjections - instrumentation</topic><topic>Microinjections - methods</topic><topic>Microneedles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Needles</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organophosphorus Compounds - administration & dosage</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verbaan, F.J.</creatorcontrib><creatorcontrib>Bal, S.M.</creatorcontrib><creatorcontrib>van den Berg, D.J.</creatorcontrib><creatorcontrib>Dijksman, J.A.</creatorcontrib><creatorcontrib>van Hecke, M.</creatorcontrib><creatorcontrib>Verpoorten, H.</creatorcontrib><creatorcontrib>van den Berg, A.</creatorcontrib><creatorcontrib>Luttge, R.</creatorcontrib><creatorcontrib>Bouwstra, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verbaan, F.J.</au><au>Bal, S.M.</au><au>van den Berg, D.J.</au><au>Dijksman, J.A.</au><au>van Hecke, M.</au><au>Verpoorten, H.</au><au>van den Berg, A.</au><au>Luttge, R.</au><au>Bouwstra, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2008-05-22</date><risdate>2008</risdate><volume>128</volume><issue>1</issue><spage>80</spage><epage>88</epage><pages>80-88</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>An electrical applicator was designed, which can pierce short microneedles into the skin with a predefined velocity. Three different shapes of microneedles were used, namely 300 μm assembled hollow metal microneedle arrays, 300 μm solid metal microneedle arrays and 245 μm hollow silicon microneedle arrays. The latter are available as 4
×
4, 6
×
6 and 9
×
9 arrays.
When using a velocity of 1 or 3 m/s reproducible piercing of dermatomed and full thickness human skin was evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and the presence of fluorescently labeled particles in dermatomed skin. Manual piercing did not result in the appearance of blue spots. Transport studies revealed that i) piercing of microneedles with a predefined velocity into human skin resulted in a drastic enhancement of the Cascade Blue (CB, Mw 538) transport, ii) A higher piercing velocity resulted in a higher CB transport rate, iii) The CB transport rate was also dependent on the shape of the microneedles and iv) no difference in transport rate was observed between 4
×
4, 6
×
6 and 9
×
9 hollow silicon microneedle arrays.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18394741</pmid><doi>10.1016/j.jconrel.2008.02.009</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2008-05, Vol.128 (1), p.80-88 |
| issn | 0168-3659 1873-4995 |
| language | eng |
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| subjects | Biological and medical sciences Chromatography, High Pressure Liquid Electric applicator Fluorescein-5-isothiocyanate - administration & dosage Fluorescent Dyes - administration & dosage General pharmacology Human skin Humans In vitro transport Injections, Subcutaneous - instrumentation Injections, Subcutaneous - methods Medical sciences Microinjections - instrumentation Microinjections - methods Microneedles Nanoparticles - administration & dosage Needles Organometallic Compounds - administration & dosage Organophosphorus Compounds - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin |
| title | Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method |
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