Alveolar deposition of fibers in rodents and humans
Alveolar deposition fractions (respirability) of inhaled fibers in rats, hamsters, and humans were calculated based on previously developed deposition models. Because of differences in airway size and ventilation condition, humans were found to have a greater deposition fraction than rodents. Nevert...
Gespeichert in:
| Veröffentlicht in: | Journal of aerosol medicine 1998, Vol.11 (4), p.247-258 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 258 |
|---|---|
| container_issue | 4 |
| container_start_page | 247 |
| container_title | Journal of aerosol medicine |
| container_volume | 11 |
| creator | DAI, Y. T YU, C. P |
| description | Alveolar deposition fractions (respirability) of inhaled fibers in rats, hamsters, and humans were calculated based on previously developed deposition models. Because of differences in airway size and ventilation condition, humans were found to have a greater deposition fraction than rodents. Nevertheless, the deposition curve (alveolar deposition fraction vs fiber aerodynamic diameter) for all species has a similar shape which exhibits two peak deposition values. Increasing the aspect ratio or decreasing the mass density of the fiber shifts the deposition curve to lower aerodynamic diameters and reduces the values of peak deposition. For fiber aerodynamic diameters greater than 3.5 microns and aspect ratios greater than 10, rodents were found to have no alveolar deposition, whereas the human deposition remains appreciable. |
| doi_str_mv | 10.1089/jam.1998.11.247 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69183629</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69183629</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-3ef1cc6770f3e8a6cbe2ad0360f9c4182c86efd5c7a7afd74c4035bd6897df953</originalsourceid><addsrcrecordid>eNpN0DtPwzAUhmELgWgpzGwoA2JL6luO7bGquEmVWGC2HF9EqiQudoPEvydVK8F0lud8w4vQLcEVwVItt6aviFKyIqSiXJyhOalrUSpM4RzNJ8FLCpLP0FXOW4wxcCku0YxgxgFAzBFbdd8-diYVzu9ibvdtHIoYitA2PuWiHYoUnR_2uTCDKz7H3gz5Gl0E02V_c7oL9PH0-L5-KTdvz6_r1aa0jNJ9yXwg1oIQODAvDdjGU-MwAxyU5URSK8EHV1thhAlOcMsxqxsHUgkXVM0W6OG4u0vxa_R5r_s2W991ZvBxzBoUkQyomuDyCG2KOScf9C61vUk_mmB96KSnTvrQSROip07Tx91pemx67_75Y5gJ3J-AydZ0IZnBtvnPAaEMOPsFd7RwaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69183629</pqid></control><display><type>article</type><title>Alveolar deposition of fibers in rodents and humans</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>DAI, Y. T ; YU, C. P</creator><creatorcontrib>DAI, Y. T ; YU, C. P</creatorcontrib><description>Alveolar deposition fractions (respirability) of inhaled fibers in rats, hamsters, and humans were calculated based on previously developed deposition models. Because of differences in airway size and ventilation condition, humans were found to have a greater deposition fraction than rodents. Nevertheless, the deposition curve (alveolar deposition fraction vs fiber aerodynamic diameter) for all species has a similar shape which exhibits two peak deposition values. Increasing the aspect ratio or decreasing the mass density of the fiber shifts the deposition curve to lower aerodynamic diameters and reduces the values of peak deposition. For fiber aerodynamic diameters greater than 3.5 microns and aspect ratios greater than 10, rodents were found to have no alveolar deposition, whereas the human deposition remains appreciable.</description><identifier>ISSN: 0894-2684</identifier><identifier>EISSN: 1557-9026</identifier><identifier>DOI: 10.1089/jam.1998.11.247</identifier><identifier>PMID: 10346667</identifier><identifier>CODEN: JAEMEP</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Air ; Animals ; Biological and medical sciences ; Cricetinae ; Environmental pollutants toxicology ; Health technology assessment ; Humans ; Medical sciences ; Mineral Fibers ; Models, Theoretical ; Mucociliary Clearance - physiology ; Particle Size ; Pulmonary Alveoli - metabolism ; Pulmonary Ventilation - physiology ; Rats ; Species Specificity ; Toxicology</subject><ispartof>Journal of aerosol medicine, 1998, Vol.11 (4), p.247-258</ispartof><rights>1999 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-3ef1cc6770f3e8a6cbe2ad0360f9c4182c86efd5c7a7afd74c4035bd6897df953</citedby><cites>FETCH-LOGICAL-c322t-3ef1cc6770f3e8a6cbe2ad0360f9c4182c86efd5c7a7afd74c4035bd6897df953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1612364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10346667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DAI, Y. T</creatorcontrib><creatorcontrib>YU, C. P</creatorcontrib><title>Alveolar deposition of fibers in rodents and humans</title><title>Journal of aerosol medicine</title><addtitle>J Aerosol Med</addtitle><description>Alveolar deposition fractions (respirability) of inhaled fibers in rats, hamsters, and humans were calculated based on previously developed deposition models. Because of differences in airway size and ventilation condition, humans were found to have a greater deposition fraction than rodents. Nevertheless, the deposition curve (alveolar deposition fraction vs fiber aerodynamic diameter) for all species has a similar shape which exhibits two peak deposition values. Increasing the aspect ratio or decreasing the mass density of the fiber shifts the deposition curve to lower aerodynamic diameters and reduces the values of peak deposition. For fiber aerodynamic diameters greater than 3.5 microns and aspect ratios greater than 10, rodents were found to have no alveolar deposition, whereas the human deposition remains appreciable.</description><subject>Air</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cricetinae</subject><subject>Environmental pollutants toxicology</subject><subject>Health technology assessment</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mineral Fibers</subject><subject>Models, Theoretical</subject><subject>Mucociliary Clearance - physiology</subject><subject>Particle Size</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Rats</subject><subject>Species Specificity</subject><subject>Toxicology</subject><issn>0894-2684</issn><issn>1557-9026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0DtPwzAUhmELgWgpzGwoA2JL6luO7bGquEmVWGC2HF9EqiQudoPEvydVK8F0lud8w4vQLcEVwVItt6aviFKyIqSiXJyhOalrUSpM4RzNJ8FLCpLP0FXOW4wxcCku0YxgxgFAzBFbdd8-diYVzu9ibvdtHIoYitA2PuWiHYoUnR_2uTCDKz7H3gz5Gl0E02V_c7oL9PH0-L5-KTdvz6_r1aa0jNJ9yXwg1oIQODAvDdjGU-MwAxyU5URSK8EHV1thhAlOcMsxqxsHUgkXVM0W6OG4u0vxa_R5r_s2W991ZvBxzBoUkQyomuDyCG2KOScf9C61vUk_mmB96KSnTvrQSROip07Tx91pemx67_75Y5gJ3J-AydZ0IZnBtvnPAaEMOPsFd7RwaQ</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>DAI, Y. T</creator><creator>YU, C. P</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Alveolar deposition of fibers in rodents and humans</title><author>DAI, Y. T ; YU, C. P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-3ef1cc6770f3e8a6cbe2ad0360f9c4182c86efd5c7a7afd74c4035bd6897df953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Air</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cricetinae</topic><topic>Environmental pollutants toxicology</topic><topic>Health technology assessment</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mineral Fibers</topic><topic>Models, Theoretical</topic><topic>Mucociliary Clearance - physiology</topic><topic>Particle Size</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Rats</topic><topic>Species Specificity</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>DAI, Y. T</creatorcontrib><creatorcontrib>YU, C. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of aerosol medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DAI, Y. T</au><au>YU, C. P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alveolar deposition of fibers in rodents and humans</atitle><jtitle>Journal of aerosol medicine</jtitle><addtitle>J Aerosol Med</addtitle><date>1998</date><risdate>1998</risdate><volume>11</volume><issue>4</issue><spage>247</spage><epage>258</epage><pages>247-258</pages><issn>0894-2684</issn><eissn>1557-9026</eissn><coden>JAEMEP</coden><abstract>Alveolar deposition fractions (respirability) of inhaled fibers in rats, hamsters, and humans were calculated based on previously developed deposition models. Because of differences in airway size and ventilation condition, humans were found to have a greater deposition fraction than rodents. Nevertheless, the deposition curve (alveolar deposition fraction vs fiber aerodynamic diameter) for all species has a similar shape which exhibits two peak deposition values. Increasing the aspect ratio or decreasing the mass density of the fiber shifts the deposition curve to lower aerodynamic diameters and reduces the values of peak deposition. For fiber aerodynamic diameters greater than 3.5 microns and aspect ratios greater than 10, rodents were found to have no alveolar deposition, whereas the human deposition remains appreciable.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>10346667</pmid><doi>10.1089/jam.1998.11.247</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0894-2684 |
| ispartof | Journal of aerosol medicine, 1998, Vol.11 (4), p.247-258 |
| issn | 0894-2684 1557-9026 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69183629 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Air Animals Biological and medical sciences Cricetinae Environmental pollutants toxicology Health technology assessment Humans Medical sciences Mineral Fibers Models, Theoretical Mucociliary Clearance - physiology Particle Size Pulmonary Alveoli - metabolism Pulmonary Ventilation - physiology Rats Species Specificity Toxicology |
| title | Alveolar deposition of fibers in rodents and humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A03%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alveolar%20deposition%20of%20fibers%20in%20rodents%20and%20humans&rft.jtitle=Journal%20of%20aerosol%20medicine&rft.au=DAI,%20Y.%20T&rft.date=1998&rft.volume=11&rft.issue=4&rft.spage=247&rft.epage=258&rft.pages=247-258&rft.issn=0894-2684&rft.eissn=1557-9026&rft.coden=JAEMEP&rft_id=info:doi/10.1089/jam.1998.11.247&rft_dat=%3Cproquest_cross%3E69183629%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69183629&rft_id=info:pmid/10346667&rfr_iscdi=true |