Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit
The fruit of Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main li...
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| Veröffentlicht in: | Journal of ethnopharmacology 2008-05, Vol.117 (3), p.463-466 |
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| creator | Xie, Fan Zhang, Mian Zhang, Chao-Feng Wang, Zheng-Tao Yu, Bo-Yang Kou, Jun-Ping |
| description | The fruit of
Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpenoids isolated from MTF.
The ethanolic extract of MTF and two limonoids, isotoosendanin (
1) and 1-
O-tigloyl-1-
O-debenzoylohchinal (
2) were evaluated for their anti-inflammatory and analgesic activities. Acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests in mice were used to investigate anti-inflammatory activity; and acetic acid-induced writhing and hot-plate tests in mice were used to determine analgesic effect.
Both the ethanolic extract and two limonoids displayed significant anti-inflammatory effects. Although the ethanolic extract showed remarkable analgesic effects in both writhing and hot-plate tests, the two limonoids had analgesic effects just in writhing test.
The results suggested that the ethanolic extract of MTF had obvious anti-inflammatory and analgesic activities, and the two limonoids were the active constituents contributing to the anti-inflammatory and analgesic effects of MTF. |
| doi_str_mv | 10.1016/j.jep.2008.02.025 |
| format | Article |
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Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpenoids isolated from MTF.
The ethanolic extract of MTF and two limonoids, isotoosendanin (
1) and 1-
O-tigloyl-1-
O-debenzoylohchinal (
2) were evaluated for their anti-inflammatory and analgesic activities. Acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests in mice were used to investigate anti-inflammatory activity; and acetic acid-induced writhing and hot-plate tests in mice were used to determine analgesic effect.
Both the ethanolic extract and two limonoids displayed significant anti-inflammatory effects. Although the ethanolic extract showed remarkable analgesic effects in both writhing and hot-plate tests, the two limonoids had analgesic effects just in writhing test.
The results suggested that the ethanolic extract of MTF had obvious anti-inflammatory and analgesic activities, and the two limonoids were the active constituents contributing to the anti-inflammatory and analgesic effects of MTF.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.02.025</identifier><identifier>PMID: 18384989</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1- O-Tigloyl-1- O-debenzoylohchinal ; Acetic Acid ; Analgesic ; analgesic effect ; Analgesics - pharmacology ; Animals ; Anti-inflammatory ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biological and medical sciences ; Capillary Permeability - drug effects ; Carrageenan ; Edema - chemically induced ; Edema - prevention & control ; Ethanol ; Ethanolic extract ; Female ; Fruit - chemistry ; fruits (plant anatomy) ; General pharmacology ; herbal medicines ; Hot Temperature ; inflammation ; Isotoosendanin ; Limonins - isolation & purification ; Limonins - pharmacology ; limonoids ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Melia ; Melia - chemistry ; Melia azedarach ; Melia toosendan fruit (MTF) ; Mice ; Mice, Inbred ICR ; pain ; Pain Measurement - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Reaction Time - drug effects ; Solvents ; triterpenoids</subject><ispartof>Journal of ethnopharmacology, 2008-05, Vol.117 (3), p.463-466</ispartof><rights>2008 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-3597e2b4afb833c1c0ac0612466d42870d2a656f7215ed1f1ecf947b6ca48b0f3</citedby><cites>FETCH-LOGICAL-c502t-3597e2b4afb833c1c0ac0612466d42870d2a656f7215ed1f1ecf947b6ca48b0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2008.02.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20344343$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18384989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Fan</creatorcontrib><creatorcontrib>Zhang, Mian</creatorcontrib><creatorcontrib>Zhang, Chao-Feng</creatorcontrib><creatorcontrib>Wang, Zheng-Tao</creatorcontrib><creatorcontrib>Yu, Bo-Yang</creatorcontrib><creatorcontrib>Kou, Jun-Ping</creatorcontrib><title>Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The fruit of
Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpenoids isolated from MTF.
The ethanolic extract of MTF and two limonoids, isotoosendanin (
1) and 1-
O-tigloyl-1-
O-debenzoylohchinal (
2) were evaluated for their anti-inflammatory and analgesic activities. Acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests in mice were used to investigate anti-inflammatory activity; and acetic acid-induced writhing and hot-plate tests in mice were used to determine analgesic effect.
Both the ethanolic extract and two limonoids displayed significant anti-inflammatory effects. Although the ethanolic extract showed remarkable analgesic effects in both writhing and hot-plate tests, the two limonoids had analgesic effects just in writhing test.
The results suggested that the ethanolic extract of MTF had obvious anti-inflammatory and analgesic activities, and the two limonoids were the active constituents contributing to the anti-inflammatory and analgesic effects of MTF.</description><subject>1- O-Tigloyl-1- O-debenzoylohchinal</subject><subject>Acetic Acid</subject><subject>Analgesic</subject><subject>analgesic effect</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability - drug effects</subject><subject>Carrageenan</subject><subject>Edema - chemically induced</subject><subject>Edema - prevention & control</subject><subject>Ethanol</subject><subject>Ethanolic extract</subject><subject>Female</subject><subject>Fruit - chemistry</subject><subject>fruits (plant anatomy)</subject><subject>General pharmacology</subject><subject>herbal medicines</subject><subject>Hot Temperature</subject><subject>inflammation</subject><subject>Isotoosendanin</subject><subject>Limonins - isolation & purification</subject><subject>Limonins - pharmacology</subject><subject>limonoids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Melia</subject><subject>Melia - chemistry</subject><subject>Melia azedarach</subject><subject>Melia toosendan fruit (MTF)</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>pain</subject><subject>Pain Measurement - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Reaction Time - drug effects</subject><subject>Solvents</subject><subject>triterpenoids</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U9vFCEUAHBiNHZb_QBedC56m_XxZ4CJp6bRalLjQXsmLPOobJhhBba1317qbvSmCYTk8XsP8h4hLyisKVD5drve4m7NAPQaWFvDI7KiWrFeDYo_JivgSvdaCXpCTkvZAoCiAp6SE6q5FqMeVySeLzX0YfHRzrOtKd93dpnatvEGS3CddTXchhqwdMl3WL_bJcUWx581t7vfut6lLoY5LSlMpfM5zd1njMF2NaWCy2SXFtyH-ow88TYWfH48z8j1h_ffLj72V18uP12cX_VuAFZ7PowK2UZYv9GcO-rAOpCUCSknwbSCiVk5SK8YHXCinqLzo1Ab6azQG_D8jLw51N3l9GOPpZo5FIcx2gXTvhg5Uk1Hqf8LGTBBuZAN0gN0OZWS0ZtdDrPN94aCeZiF2Zo2C_MwCwOsraHlvDwW329mnP5mHJvfwOsjsMXZ6LNdXCh_HAMuBBe8uVcH520y9iY3c_2VAeXtsXGgA23i3UFg6-ptwGyKC7g4nEJGV82Uwj8--gsBILEv</recordid><startdate>20080522</startdate><enddate>20080522</enddate><creator>Xie, Fan</creator><creator>Zhang, Mian</creator><creator>Zhang, Chao-Feng</creator><creator>Wang, Zheng-Tao</creator><creator>Yu, Bo-Yang</creator><creator>Kou, Jun-Ping</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20080522</creationdate><title>Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit</title><author>Xie, Fan ; Zhang, Mian ; Zhang, Chao-Feng ; Wang, Zheng-Tao ; Yu, Bo-Yang ; Kou, Jun-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-3597e2b4afb833c1c0ac0612466d42870d2a656f7215ed1f1ecf947b6ca48b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>1- O-Tigloyl-1- O-debenzoylohchinal</topic><topic>Acetic Acid</topic><topic>Analgesic</topic><topic>analgesic effect</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-inflammatory</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability - drug effects</topic><topic>Carrageenan</topic><topic>Edema - chemically induced</topic><topic>Edema - prevention & control</topic><topic>Ethanol</topic><topic>Ethanolic extract</topic><topic>Female</topic><topic>Fruit - chemistry</topic><topic>fruits (plant anatomy)</topic><topic>General pharmacology</topic><topic>herbal medicines</topic><topic>Hot Temperature</topic><topic>inflammation</topic><topic>Isotoosendanin</topic><topic>Limonins - isolation & purification</topic><topic>Limonins - pharmacology</topic><topic>limonoids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Melia</topic><topic>Melia - chemistry</topic><topic>Melia azedarach</topic><topic>Melia toosendan fruit (MTF)</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>pain</topic><topic>Pain Measurement - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Reaction Time - drug effects</topic><topic>Solvents</topic><topic>triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Fan</creatorcontrib><creatorcontrib>Zhang, Mian</creatorcontrib><creatorcontrib>Zhang, Chao-Feng</creatorcontrib><creatorcontrib>Wang, Zheng-Tao</creatorcontrib><creatorcontrib>Yu, Bo-Yang</creatorcontrib><creatorcontrib>Kou, Jun-Ping</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Fan</au><au>Zhang, Mian</au><au>Zhang, Chao-Feng</au><au>Wang, Zheng-Tao</au><au>Yu, Bo-Yang</au><au>Kou, Jun-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-05-22</date><risdate>2008</risdate><volume>117</volume><issue>3</issue><spage>463</spage><epage>466</epage><pages>463-466</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The fruit of
Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpenoids isolated from MTF.
The ethanolic extract of MTF and two limonoids, isotoosendanin (
1) and 1-
O-tigloyl-1-
O-debenzoylohchinal (
2) were evaluated for their anti-inflammatory and analgesic activities. Acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests in mice were used to investigate anti-inflammatory activity; and acetic acid-induced writhing and hot-plate tests in mice were used to determine analgesic effect.
Both the ethanolic extract and two limonoids displayed significant anti-inflammatory effects. Although the ethanolic extract showed remarkable analgesic effects in both writhing and hot-plate tests, the two limonoids had analgesic effects just in writhing test.
The results suggested that the ethanolic extract of MTF had obvious anti-inflammatory and analgesic activities, and the two limonoids were the active constituents contributing to the anti-inflammatory and analgesic effects of MTF.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18384989</pmid><doi>10.1016/j.jep.2008.02.025</doi><tpages>4</tpages></addata></record> |
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| subjects | 1- O-Tigloyl-1- O-debenzoylohchinal Acetic Acid Analgesic analgesic effect Analgesics - pharmacology Animals Anti-inflammatory anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Capillary Permeability - drug effects Carrageenan Edema - chemically induced Edema - prevention & control Ethanol Ethanolic extract Female Fruit - chemistry fruits (plant anatomy) General pharmacology herbal medicines Hot Temperature inflammation Isotoosendanin Limonins - isolation & purification Limonins - pharmacology limonoids Male Medical sciences medicinal plants medicinal properties Melia Melia - chemistry Melia azedarach Melia toosendan fruit (MTF) Mice Mice, Inbred ICR pain Pain Measurement - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Reaction Time - drug effects Solvents triterpenoids |
| title | Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit |
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