Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus
Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1998-12, Vol.42 (6), p.817-820 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | BOUMA, M. J SNOWDON, D FAIRLAMB, A. H ACKERS, J. P |
| description | Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb. |
| doi_str_mv | 10.1093/jac/42.6.817 |
| format | Article |
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J ; SNOWDON, D ; FAIRLAMB, A. H ; ACKERS, J. P</creator><creatorcontrib>BOUMA, M. J ; SNOWDON, D ; FAIRLAMB, A. H ; ACKERS, J. P</creatorcontrib><description>Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/42.6.817</identifier><identifier>PMID: 10052908</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aerobiosis ; Anaerobiosis ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Antiprotozoal Agents - pharmacology ; Antitrichomonal Agents - pharmacology ; Biological and medical sciences ; Disulfiram - pharmacology ; Ditiocarb - pharmacology ; Drug Resistance ; Medical sciences ; Metronidazole - pharmacology ; Pharmacology. Drug treatments ; Trichomonas vaginalis - drug effects ; Trichomonas vaginalis - growth & development ; Tritrichomonas foetus - drug effects ; Tritrichomonas foetus - growth & development</subject><ispartof>Journal of antimicrobial chemotherapy, 1998-12, Vol.42 (6), p.817-820</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-ef2d1423b83ba1e2c6ad648fd9cdc16fefd5ea4dcc4d50aeb4e1544ecf4e69ad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1658057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10052908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOUMA, M. J</creatorcontrib><creatorcontrib>SNOWDON, D</creatorcontrib><creatorcontrib>FAIRLAMB, A. H</creatorcontrib><creatorcontrib>ACKERS, J. P</creatorcontrib><title>Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb.</description><subject>Aerobiosis</subject><subject>Anaerobiosis</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antitrichomonal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Disulfiram - pharmacology</subject><subject>Ditiocarb - pharmacology</subject><subject>Drug Resistance</subject><subject>Medical sciences</subject><subject>Metronidazole - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Trichomonas vaginalis - drug effects</subject><subject>Trichomonas vaginalis - growth & development</subject><subject>Tritrichomonas foetus - drug effects</subject><subject>Tritrichomonas foetus - growth & development</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0c1q3DAUBWBRGppp2l3XxYtSEqgnki1p7GUI_YNANunaXEtXGQXbmurKA9PHy5NFmZm2WQl0vnM3h7EPgi8Fb-vLBzCXslrqZSNWr9hCSM3LirfiNVvwmqtyJVV9yt4SPXDOtdLNG3YqOFdVy5sFe7wyyW992hXBFdbTPDgfYSzOe0_n1mNa74a09sFA7GEMu-FijzZrb_GigMnmUjrExV-ff_41ID2ze_ATpWLEFMPkLfwJA5aEE-XuFvdnyojkKcGUirvozTqMYQIqtnDvJxg87VFO0ovQBUwzvWMnDgbC98f3jP369vXu-kd5c_v95_XVTWlqJVOJrrJCVnXf1D0IrIwGq2XjbGusEdqhswpBWmOkVRywlyiUlGicRN2Crc_Y58PdTQy_Z6TUjZ4MDgNMGGbqdCuaPIjM8MsBmhiIIrpuE_0IcdcJ3j1v1uXNOll1usubZf7xeHfuR7Qv8GGkDD4dAZCBwUWYjKf_TquGq1X9BEvLp-Y</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>BOUMA, M. J</creator><creator>SNOWDON, D</creator><creator>FAIRLAMB, A. H</creator><creator>ACKERS, J. P</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus</title><author>BOUMA, M. J ; SNOWDON, D ; FAIRLAMB, A. H ; ACKERS, J. P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-ef2d1423b83ba1e2c6ad648fd9cdc16fefd5ea4dcc4d50aeb4e1544ecf4e69ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aerobiosis</topic><topic>Anaerobiosis</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antitrichomonal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Disulfiram - pharmacology</topic><topic>Ditiocarb - pharmacology</topic><topic>Drug Resistance</topic><topic>Medical sciences</topic><topic>Metronidazole - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Trichomonas vaginalis - drug effects</topic><topic>Trichomonas vaginalis - growth & development</topic><topic>Tritrichomonas foetus - drug effects</topic><topic>Tritrichomonas foetus - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOUMA, M. J</creatorcontrib><creatorcontrib>SNOWDON, D</creatorcontrib><creatorcontrib>FAIRLAMB, A. H</creatorcontrib><creatorcontrib>ACKERS, J. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOUMA, M. J</au><au>SNOWDON, D</au><au>FAIRLAMB, A. H</au><au>ACKERS, J. P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>42</volume><issue>6</issue><spage>817</spage><epage>820</epage><pages>817-820</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Clinical resistance of Trichomonas vaginalis to metronidazole is best correlated with MIC values measured under aerobic conditions. Under these conditions both disulfiram (bis(diethylthiocarbamoyl)disulphide), and its first mammalian metabolite, ditiocarb (diethyldithiocarbamate), showed high levels of activity against metronidazole-sensitive (disulfiram MIC, 0.1-0.7 microM; ditiocarb MIC, 0.3-9 microM) and -resistant (MICs 0.2-1.3 microM and 1.2-9 microM respectively) isolates. Tritrichomonas foetus was also sensitive-the MICs for seven metronidazole-sensitive isolates were 0.1-1.0 microM for disulfiram and 1.0-6.9 microM for ditiocarb; those for two highly metronidazole-resistant strains were 0.3-1.3 microM and 0.6-6 microM respectively. Under anerobic conditions most strains became highly resistant to both compounds. Surprisingly, disulfiram was consistently more active than ditiocarb.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10052908</pmid><doi>10.1093/jac/42.6.817</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Free Full-Text Journals in Chemistry |
| subjects | Aerobiosis Anaerobiosis Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Antitrichomonal Agents - pharmacology Biological and medical sciences Disulfiram - pharmacology Ditiocarb - pharmacology Drug Resistance Medical sciences Metronidazole - pharmacology Pharmacology. Drug treatments Trichomonas vaginalis - drug effects Trichomonas vaginalis - growth & development Tritrichomonas foetus - drug effects Tritrichomonas foetus - growth & development |
| title | Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus |
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