Effects of Periodontal Therapy on Glycemic Control and Inflammatory Markers
Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects of periodontal therapy (scaling and root planing [SRP]) on the serum levels of glycated hemoglobin (HbA1c) and on infl...
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| creator | O'Connell, Patricia A.A. Taba, Mario Nomizo, Auro Foss Freitas, Maria C. Suaid, Flavia A. Uyemura, Sergio A. Trevisan, Glauce L. Novaes, Arthur B. Souza, Sergio L.S. Palioto, Daniela B. Grisi, Marcio F.M. |
| description | Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects of periodontal therapy (scaling and root planing [SRP]) on the serum levels of glycated hemoglobin (HbA1c) and on inflammatory biomarkers.
Methods: Thirty subjects with type 2 DM and periodontitis were treated with SRP + placebo (SRP; N = 15) or with SRP + doxycycline (SRP+Doxy; N = 15), 100 mg/day, for 14 days. Clinical and laboratory data were recorded at baseline and at 3 months after treatment.
Results: After 3 months, the reduction in probing depth was 0.8 mm for the SRP group (P |
| doi_str_mv | 10.1902/jop.2008.070250 |
| format | Article |
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Methods: Thirty subjects with type 2 DM and periodontitis were treated with SRP + placebo (SRP; N = 15) or with SRP + doxycycline (SRP+Doxy; N = 15), 100 mg/day, for 14 days. Clinical and laboratory data were recorded at baseline and at 3 months after treatment.
Results: After 3 months, the reduction in probing depth was 0.8 mm for the SRP group (P <0.01) and 1.1 mm for the SRP+Doxy group (P <0.01) followed by a 0.9% (SRP; P = 0.17) and 1.5% (SRP+Doxy; P <0.01) reduction in HbA1c levels. A significant reduction in interleukin (IL)‐6; interferon‐inducible protein 10; soluble fas ligand; granulocyte colony‐stimulating factor; RANTES; and IL‐12 p70 serum levels were also verified (N = 30). To our knowledge, this is the first report on the effects of periodontal therapy on multiple systemic inflammatory markers in DM.
Conclusions: Periodontal therapy may influence the systemic conditions of patients with type 2 DM, but no statistical difference was observed with the adjunctive systemic doxycycline therapy. Moreover, it is possible that the observed improvement in glycemic control and in the reduction of inflammatory markers could also be due to diet, which was not controlled in our study. Therefore, a confirmatory study with a larger sample size and controlled diet is necessary.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2008.070250</identifier><identifier>PMID: 18454655</identifier><language>eng</language><publisher>Chicago, IL: American Academy of Periodontology</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Blood Glucose - physiology ; Chemokine CCL5 - blood ; Chemokine CXCL10 - blood ; Combined Modality Therapy ; Cytokines - blood ; Dental Scaling ; Dentistry ; diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - immunology ; Diabetes. Impaired glucose tolerance ; Double-Blind Method ; Doxycycline - therapeutic use ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fas Ligand Protein - blood ; Female ; Follow-Up Studies ; Glycated Hemoglobin A - analysis ; Granulocyte Colony-Stimulating Factor - blood ; Humans ; inflammation ; Interleukin-12 - blood ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; periodontitis ; Periodontitis - blood ; Periodontitis - complications ; Periodontitis - immunology ; Periodontitis - therapy</subject><ispartof>Journal of periodontology (1970), 2008-05, Vol.79 (5), p.774-783</ispartof><rights>2008 American Academy of Periodontology</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4374-57b4c1fe6e1ce711246d203dcd11d50ab1b15a25ce69c7d86964f3727142f7d73</citedby><cites>FETCH-LOGICAL-c4374-57b4c1fe6e1ce711246d203dcd11d50ab1b15a25ce69c7d86964f3727142f7d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2008.070250$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2008.070250$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20337055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18454655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Connell, Patricia A.A.</creatorcontrib><creatorcontrib>Taba, Mario</creatorcontrib><creatorcontrib>Nomizo, Auro</creatorcontrib><creatorcontrib>Foss Freitas, Maria C.</creatorcontrib><creatorcontrib>Suaid, Flavia A.</creatorcontrib><creatorcontrib>Uyemura, Sergio A.</creatorcontrib><creatorcontrib>Trevisan, Glauce L.</creatorcontrib><creatorcontrib>Novaes, Arthur B.</creatorcontrib><creatorcontrib>Souza, Sergio L.S.</creatorcontrib><creatorcontrib>Palioto, Daniela B.</creatorcontrib><creatorcontrib>Grisi, Marcio F.M.</creatorcontrib><title>Effects of Periodontal Therapy on Glycemic Control and Inflammatory Markers</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects of periodontal therapy (scaling and root planing [SRP]) on the serum levels of glycated hemoglobin (HbA1c) and on inflammatory biomarkers.
Methods: Thirty subjects with type 2 DM and periodontitis were treated with SRP + placebo (SRP; N = 15) or with SRP + doxycycline (SRP+Doxy; N = 15), 100 mg/day, for 14 days. Clinical and laboratory data were recorded at baseline and at 3 months after treatment.
Results: After 3 months, the reduction in probing depth was 0.8 mm for the SRP group (P <0.01) and 1.1 mm for the SRP+Doxy group (P <0.01) followed by a 0.9% (SRP; P = 0.17) and 1.5% (SRP+Doxy; P <0.01) reduction in HbA1c levels. A significant reduction in interleukin (IL)‐6; interferon‐inducible protein 10; soluble fas ligand; granulocyte colony‐stimulating factor; RANTES; and IL‐12 p70 serum levels were also verified (N = 30). To our knowledge, this is the first report on the effects of periodontal therapy on multiple systemic inflammatory markers in DM.
Conclusions: Periodontal therapy may influence the systemic conditions of patients with type 2 DM, but no statistical difference was observed with the adjunctive systemic doxycycline therapy. Moreover, it is possible that the observed improvement in glycemic control and in the reduction of inflammatory markers could also be due to diet, which was not controlled in our study. Therefore, a confirmatory study with a larger sample size and controlled diet is necessary.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - physiology</subject><subject>Chemokine CCL5 - blood</subject><subject>Chemokine CXCL10 - blood</subject><subject>Combined Modality Therapy</subject><subject>Cytokines - blood</subject><subject>Dental Scaling</subject><subject>Dentistry</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Double-Blind Method</subject><subject>Doxycycline - therapeutic use</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fas Ligand Protein - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Granulocyte Colony-Stimulating Factor - blood</subject><subject>Humans</subject><subject>inflammation</subject><subject>Interleukin-12 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>periodontitis</subject><subject>Periodontitis - blood</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - immunology</subject><subject>Periodontitis - therapy</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtPAjEQhxujEXycvZle9LbQ53b3aAgiipEYPDelj7jY3WILMfvfuwjRo6fJZL75TeYD4AqjAS4RGa7CekAQKgZIIMLREejjktGM5gIdgz5ChGSUlaQHzlJadS1mFJ2CHi4YZznnffA0ds7qTYLBwbmNVTCh2SgPF-82qnULQwMnvtW2rjQcdaMYPFSNgdPGeVXXahNiC59V_LAxXYATp3yyl4d6Dt7ux4vRQzZ7mUxHd7NMMypYxsWSaexsbrG2AmPCckMQNdpgbDhSS7zEXBGubV5qYYq8zJmjggjMiBNG0HNwu89dx_C5tWkj6ypp671qbNgmmZdYlEXBO3C4B3UMKUXr5DpWtYqtxEju_MnOn9z5k3t_3cb1IXq7rK354w_COuDmAKiklXdRNbpKv1z3BxXoh-N77qvytv3vrnycj1-REIx-A4BxiCM</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>O'Connell, Patricia A.A.</creator><creator>Taba, Mario</creator><creator>Nomizo, Auro</creator><creator>Foss Freitas, Maria C.</creator><creator>Suaid, Flavia A.</creator><creator>Uyemura, Sergio A.</creator><creator>Trevisan, Glauce L.</creator><creator>Novaes, Arthur B.</creator><creator>Souza, Sergio L.S.</creator><creator>Palioto, Daniela B.</creator><creator>Grisi, Marcio F.M.</creator><general>American Academy of Periodontology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Effects of Periodontal Therapy on Glycemic Control and Inflammatory Markers</title><author>O'Connell, Patricia A.A. ; Taba, Mario ; Nomizo, Auro ; Foss Freitas, Maria C. ; Suaid, Flavia A. ; Uyemura, Sergio A. ; Trevisan, Glauce L. ; Novaes, Arthur B. ; Souza, Sergio L.S. ; Palioto, Daniela B. ; Grisi, Marcio F.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4374-57b4c1fe6e1ce711246d203dcd11d50ab1b15a25ce69c7d86964f3727142f7d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - physiology</topic><topic>Chemokine CCL5 - blood</topic><topic>Chemokine CXCL10 - blood</topic><topic>Combined Modality Therapy</topic><topic>Cytokines - blood</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Double-Blind Method</topic><topic>Doxycycline - therapeutic use</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fas Ligand Protein - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Granulocyte Colony-Stimulating Factor - blood</topic><topic>Humans</topic><topic>inflammation</topic><topic>Interleukin-12 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>periodontitis</topic><topic>Periodontitis - blood</topic><topic>Periodontitis - complications</topic><topic>Periodontitis - immunology</topic><topic>Periodontitis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Connell, Patricia A.A.</creatorcontrib><creatorcontrib>Taba, Mario</creatorcontrib><creatorcontrib>Nomizo, Auro</creatorcontrib><creatorcontrib>Foss Freitas, Maria C.</creatorcontrib><creatorcontrib>Suaid, Flavia A.</creatorcontrib><creatorcontrib>Uyemura, Sergio A.</creatorcontrib><creatorcontrib>Trevisan, Glauce L.</creatorcontrib><creatorcontrib>Novaes, Arthur B.</creatorcontrib><creatorcontrib>Souza, Sergio L.S.</creatorcontrib><creatorcontrib>Palioto, Daniela B.</creatorcontrib><creatorcontrib>Grisi, Marcio F.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Connell, Patricia A.A.</au><au>Taba, Mario</au><au>Nomizo, Auro</au><au>Foss Freitas, Maria C.</au><au>Suaid, Flavia A.</au><au>Uyemura, Sergio A.</au><au>Trevisan, Glauce L.</au><au>Novaes, Arthur B.</au><au>Souza, Sergio L.S.</au><au>Palioto, Daniela B.</au><au>Grisi, Marcio F.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Periodontal Therapy on Glycemic Control and Inflammatory Markers</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2008-05</date><risdate>2008</risdate><volume>79</volume><issue>5</issue><spage>774</spage><epage>783</epage><pages>774-783</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Periodontitis, a complication of diabetes mellitus (DM), can induce or perpetuate systemic conditions. This double‐masked, placebo‐controlled study evaluated the effects of periodontal therapy (scaling and root planing [SRP]) on the serum levels of glycated hemoglobin (HbA1c) and on inflammatory biomarkers.
Methods: Thirty subjects with type 2 DM and periodontitis were treated with SRP + placebo (SRP; N = 15) or with SRP + doxycycline (SRP+Doxy; N = 15), 100 mg/day, for 14 days. Clinical and laboratory data were recorded at baseline and at 3 months after treatment.
Results: After 3 months, the reduction in probing depth was 0.8 mm for the SRP group (P <0.01) and 1.1 mm for the SRP+Doxy group (P <0.01) followed by a 0.9% (SRP; P = 0.17) and 1.5% (SRP+Doxy; P <0.01) reduction in HbA1c levels. A significant reduction in interleukin (IL)‐6; interferon‐inducible protein 10; soluble fas ligand; granulocyte colony‐stimulating factor; RANTES; and IL‐12 p70 serum levels were also verified (N = 30). To our knowledge, this is the first report on the effects of periodontal therapy on multiple systemic inflammatory markers in DM.
Conclusions: Periodontal therapy may influence the systemic conditions of patients with type 2 DM, but no statistical difference was observed with the adjunctive systemic doxycycline therapy. Moreover, it is possible that the observed improvement in glycemic control and in the reduction of inflammatory markers could also be due to diet, which was not controlled in our study. Therefore, a confirmatory study with a larger sample size and controlled diet is necessary.</abstract><cop>Chicago, IL</cop><pub>American Academy of Periodontology</pub><pmid>18454655</pmid><doi>10.1902/jop.2008.070250</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Anti-Bacterial Agents - therapeutic use Biological and medical sciences Biomarkers Biomarkers - blood Blood Glucose - physiology Chemokine CCL5 - blood Chemokine CXCL10 - blood Combined Modality Therapy Cytokines - blood Dental Scaling Dentistry diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology Diabetes. Impaired glucose tolerance Double-Blind Method Doxycycline - therapeutic use Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fas Ligand Protein - blood Female Follow-Up Studies Glycated Hemoglobin A - analysis Granulocyte Colony-Stimulating Factor - blood Humans inflammation Interleukin-12 - blood Interleukin-6 - blood Male Medical sciences Middle Aged periodontitis Periodontitis - blood Periodontitis - complications Periodontitis - immunology Periodontitis - therapy |
| title | Effects of Periodontal Therapy on Glycemic Control and Inflammatory Markers |
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