Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane

We have targeted CD22 as a novel tumor-associated Ag for recognition by human CTL genetically modified to express chimeric TCR (cTCR) recognizing this surface molecule. CD22-specific cTCR targeting different epitopes of the CD22 molecule promoted efficient lysis of target cells expressing high level...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-05, Vol.180 (10), p.7028-7038
Hauptverfasser:	James, Scott E, Greenberg, Philip D, Jensen, Michael C, Lin, Yukang, Wang, Jinjuan, Till, Brian G, Raubitschek, Andrew A, Forman, Stephen J, Press, Oliver W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell Membrane - chemistry Cytotoxicity, Immunologic Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Flow Cytometry Humans Immunotherapy - methods Leukemia, B-Cell - therapy Lymphoma, B-Cell - therapy Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology
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