Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone

In the course of our screening for chemical immunomodulators from microbial metabolites, we found that an actinomycete strain (RK95-31) isolated from a soil sample collected in Fukuyama City, Hiroshima Prefecture, Japan, produced a novel immunosuppressant, cytoxazone (Fig. 1). The strain RK95-31 was...

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Veröffentlicht in:	Journal of antibiotics 1998/12/25, Vol.51(12), pp.1126-1128
Hauptverfasser:	KAKEYA, HIDEAKI, MORISHITA, MASAYUKI, KOBINATA, KIMIE, OSONO, MICHIYO, ISHIZUKA, MASAAKI, OSADA, HIROYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Cytokines - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Immunosuppressive Agents - chemistry Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Interleukin-10 - biosynthesis Interleukin-4 - biosynthesis Magnetic Resonance Spectroscopy Mice Mice, Inbred BALB C Molecular Structure Oxazoles - chemistry Oxazoles - isolation & purification Oxazoles - pharmacology Spleen - drug effects Spleen - immunology Streptomyces Streptomyces - chemistry Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology
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