Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone
In the course of our screening for chemical immunomodulators from microbial metabolites, we found that an actinomycete strain (RK95-31) isolated from a soil sample collected in Fukuyama City, Hiroshima Prefecture, Japan, produced a novel immunosuppressant, cytoxazone (Fig. 1). The strain RK95-31 was...
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| Veröffentlicht in: | Journal of antibiotics 1998/12/25, Vol.51(12), pp.1126-1128 |
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| container_issue | 12 |
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| container_title | Journal of antibiotics |
| container_volume | 51 |
| creator | KAKEYA, HIDEAKI MORISHITA, MASAYUKI KOBINATA, KIMIE OSONO, MICHIYO ISHIZUKA, MASAAKI OSADA, HIROYUKI |
| description | In the course of our screening for chemical immunomodulators from microbial metabolites, we found that an actinomycete strain (RK95-31) isolated from a soil sample collected in Fukuyama City, Hiroshima Prefecture, Japan, produced a novel immunosuppressant, cytoxazone (Fig. 1). The strain RK95-31 was identified to be Streptomyces sp. and deposited in the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Japan, with the accession No. FERM P-16171. |
| doi_str_mv | 10.7164/antibiotics.51.1126 |
| format | Article |
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The strain RK95-31 was identified to be Streptomyces sp. and deposited in the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Japan, with the accession No. FERM P-16171.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.51.1126</identifier><identifier>PMID: 10048575</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>AIDS/HIV ; Animals ; Cytokines - biosynthesis ; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis ; Humans ; Immunosuppressive Agents - chemistry ; Immunosuppressive Agents - isolation & purification ; Immunosuppressive Agents - pharmacology ; Interleukin-10 - biosynthesis ; Interleukin-4 - biosynthesis ; Magnetic Resonance Spectroscopy ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Oxazoles - chemistry ; Oxazoles - isolation & purification ; Oxazoles - pharmacology ; Spleen - drug effects ; Spleen - immunology ; Streptomyces ; Streptomyces - chemistry ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>The Journal of Antibiotics, 1998/12/25, Vol.51(12), pp.1126-1128</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c681t-b7ea1efbf836153e5becc158d239fc184f2ab89a4b91b80d32d60bc7e53800533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10048575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAKEYA, HIDEAKI</creatorcontrib><creatorcontrib>MORISHITA, MASAYUKI</creatorcontrib><creatorcontrib>KOBINATA, KIMIE</creatorcontrib><creatorcontrib>OSONO, MICHIYO</creatorcontrib><creatorcontrib>ISHIZUKA, MASAAKI</creatorcontrib><creatorcontrib>OSADA, HIROYUKI</creatorcontrib><title>Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>In the course of our screening for chemical immunomodulators from microbial metabolites, we found that an actinomycete strain (RK95-31) isolated from a soil sample collected in Fukuyama City, Hiroshima Prefecture, Japan, produced a novel immunosuppressant, cytoxazone (Fig. 1). 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MORISHITA, MASAYUKI ; KOBINATA, KIMIE ; OSONO, MICHIYO ; ISHIZUKA, MASAAKI ; OSADA, HIROYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c681t-b7ea1efbf836153e5becc158d239fc184f2ab89a4b91b80d32d60bc7e53800533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Cytokines - biosynthesis</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis</topic><topic>Humans</topic><topic>Immunosuppressive Agents - chemistry</topic><topic>Immunosuppressive Agents - isolation & purification</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Structure</topic><topic>Oxazoles - chemistry</topic><topic>Oxazoles - isolation & purification</topic><topic>Oxazoles - pharmacology</topic><topic>Spleen - drug effects</topic><topic>Spleen - immunology</topic><topic>Streptomyces</topic><topic>Streptomyces - chemistry</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAKEYA, HIDEAKI</creatorcontrib><creatorcontrib>MORISHITA, MASAYUKI</creatorcontrib><creatorcontrib>KOBINATA, KIMIE</creatorcontrib><creatorcontrib>OSONO, MICHIYO</creatorcontrib><creatorcontrib>ISHIZUKA, MASAAKI</creatorcontrib><creatorcontrib>OSADA, HIROYUKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAKEYA, HIDEAKI</au><au>MORISHITA, MASAYUKI</au><au>KOBINATA, KIMIE</au><au>OSONO, MICHIYO</au><au>ISHIZUKA, MASAAKI</au><au>OSADA, HIROYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1998</date><risdate>1998</risdate><volume>51</volume><issue>12</issue><spage>1126</spage><epage>1128</epage><pages>1126-1128</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>In the course of our screening for chemical immunomodulators from microbial metabolites, we found that an actinomycete strain (RK95-31) isolated from a soil sample collected in Fukuyama City, Hiroshima Prefecture, Japan, produced a novel immunosuppressant, cytoxazone (Fig. 1). The strain RK95-31 was identified to be Streptomyces sp. and deposited in the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Japan, with the accession No. FERM P-16171.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>10048575</pmid><doi>10.7164/antibiotics.51.1126</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1998/12/25, Vol.51(12), pp.1126-1128 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69179000 |
| source | J-STAGE Free; MEDLINE |
| subjects | AIDS/HIV Animals Cytokines - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Humans Immunosuppressive Agents - chemistry Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Interleukin-10 - biosynthesis Interleukin-4 - biosynthesis Magnetic Resonance Spectroscopy Mice Mice, Inbred BALB C Molecular Structure Oxazoles - chemistry Oxazoles - isolation & purification Oxazoles - pharmacology Spleen - drug effects Spleen - immunology Streptomyces Streptomyces - chemistry Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology |
| title | Isolation and Biological Activity of a Novel Cytokine Modulator, Cytoxazone |
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