BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth

The environment of the adult CNS prevents axonal regeneration after injury. This inhibition of axonal regeneration can be blocked by elevating cAMP. Previously, we showed that the cAMP pathway can be activated via pre-treatment with neurotrophins and requires activation of several signaling pathways...

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Veröffentlicht in:	Molecular and cellular neuroscience 2008-05, Vol.38 (1), p.110-116
Hauptverfasser:	Spencer, Timothy K., Mellado, Wilfredo, Filbin, Marie T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - physiology Calcium-Calmodulin-Dependent Protein Kinase Type 4 - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 4 - physiology Cells, Cultured CHO Cells Coculture Techniques Cricetinae Cricetulus Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic AMP-Dependent Protein Kinases - physiology Enzyme Activation - physiology Growth Inhibitors - metabolism Growth Inhibitors - physiology Mice Myelin-Associated Glycoprotein - antagonists & inhibitors Myelin-Associated Glycoprotein - physiology Neural Inhibition - physiology Neural Pathways - physiology Neurites - physiology Phosphorylation Rats
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