Interferon‐γ signal transduction during parasite infection: modulation of MAP kinases in the infection of human monocyte cells (THP1) by Toxoplasma gondii

We assayed mitogen‐activated protein (MAP) kinase phosphorylation in a human monocyte cell line (THP1) during their infection by Toxoplasma gondii. In addition, we tested the effect of specific MAP kinase inhibitors (PD098059 and SB203580) on parasite invasion. MAP kinase phosphorylation was increas...

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Veröffentlicht in:	Parasite immunology 1998-12, Vol.20 (12), p.631-635
Hauptverfasser:	GOMEZ‐MARIN, JORGE E., VALERE, AUDREY, BONHOMME, ANNIE, EL'BTAOURI, HASSAN, ANTONICELLI, FRANK, BURLET, HENRIETTE, AUBERT, DOMINIQUE, VILLENA, ISABELLE, GUENOUNOU, MONCEF, HAYE3, BERNARD, PINON, JEAN M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Cell Membrane - metabolism Cytosol - metabolism Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Host-Parasite Interactions - drug effects human monocytes Humans IFN‐γ Imidazoles - pharmacology Interferon-gamma - pharmacology MAP kinase Monocytes - drug effects Monocytes - enzymology Monocytes - parasitology Phosphorylation - drug effects Pyridines - pharmacology Signal Transduction - immunology T. gondii Toxoplasma gondii Toxoplasmosis - enzymology Toxoplasmosis - immunology
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