Rac1 is required for the formation of three germ layers during gastrulation
The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and...
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| Veröffentlicht in: | Oncogene 1998-12, Vol.17 (26), p.3427-3433 |
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| container_title | Oncogene |
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| creator | SUGIHARA, K NAKATSUJI, N KATSUKI, M NAKAMURA, K NAKAO, K HASHIMOTO, R OTANI, H SAKAGAMI, H KONDO, H NOZAWA, S AIBA, A |
| description | The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and endoderm at the primitive streak stage. Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo. These results suggest that Rac1-mediated cell adhesion is essential for the formation of three germ layers during gastrulation. |
| doi_str_mv | 10.1038/sj.onc.1202595 |
| format | Article |
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We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and endoderm at the primitive streak stage. Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo. These results suggest that Rac1-mediated cell adhesion is essential for the formation of three germ layers during gastrulation.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1202595</identifier><identifier>PMID: 10030666</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Actin ; Animals ; Biological and medical sciences ; Cell adhesion ; Cell adhesion & migration ; Cell Adhesion - genetics ; Cell culture ; Cell interactions, adhesion ; Cell migration ; Cell Movement - genetics ; Cytoskeleton ; Ectoderm ; Embryogenesis ; Endoderm ; Fetal Death - genetics ; Fundamental and applied biological sciences. Psychology ; Gastrula - cytology ; Gastrula - physiology ; Gastrulation ; Gene Expression Regulation, Developmental ; Genes, Lethal ; Genetic analysis ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; Lamellipodia ; Mice ; Mice, Knockout ; Molecular and cellular biology ; Primitive streak ; Pseudopodia ; rac GTP-Binding Proteins ; Rac1 protein</subject><ispartof>Oncogene, 1998-12, Vol.17 (26), p.3427-3433</ispartof><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-eaab4420e4e86b26e1ba360dbe0c81e2ef7abed0f257217e08d5be62907a18303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1675603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10030666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUGIHARA, K</creatorcontrib><creatorcontrib>NAKATSUJI, N</creatorcontrib><creatorcontrib>KATSUKI, M</creatorcontrib><creatorcontrib>NAKAMURA, K</creatorcontrib><creatorcontrib>NAKAO, K</creatorcontrib><creatorcontrib>HASHIMOTO, R</creatorcontrib><creatorcontrib>OTANI, H</creatorcontrib><creatorcontrib>SAKAGAMI, H</creatorcontrib><creatorcontrib>KONDO, H</creatorcontrib><creatorcontrib>NOZAWA, S</creatorcontrib><creatorcontrib>AIBA, A</creatorcontrib><title>Rac1 is required for the formation of three germ layers during gastrulation</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development. The rac1 deficient embryos showed numerous cell deaths in the space between the embryonic ectoderm and endoderm at the primitive streak stage. Investigation of the primary epiblast culture isolated from rac1 deficient embryos indicated that Rac1 is involved in lamellipodia formation, cell adhesion and cell migration in vivo. 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| ispartof | Oncogene, 1998-12, Vol.17 (26), p.3427-3433 |
| issn | 0950-9232 1476-5594 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Actin Animals Biological and medical sciences Cell adhesion Cell adhesion & migration Cell Adhesion - genetics Cell culture Cell interactions, adhesion Cell migration Cell Movement - genetics Cytoskeleton Ectoderm Embryogenesis Endoderm Fetal Death - genetics Fundamental and applied biological sciences. Psychology Gastrula - cytology Gastrula - physiology Gastrulation Gene Expression Regulation, Developmental Genes, Lethal Genetic analysis GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Lamellipodia Mice Mice, Knockout Molecular and cellular biology Primitive streak Pseudopodia rac GTP-Binding Proteins Rac1 protein |
| title | Rac1 is required for the formation of three germ layers during gastrulation |
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