HMGB1 protein inhibits DNA replication in vitro: A role of the acetylation and the acidic tail

The high mobility group box (HMGB) 1 protein is a very abundant and conserved protein that is implicated in many key cellular events but its functions within the nucleus remain elusive. The role of this protein in replication of closed circular DNA containing a eukaryotic origin of replication has b...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2008, Vol.40 (8), p.1536-1542
Hauptverfasser:	Topalova, Dessislava, Ugrinova, Iva, Pashev, Iliya G., Pasheva, Evdokia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acidic tail Animals Aphidicolin - pharmacology DNA replication DNA Replication - drug effects DNA, Circular - metabolism High Mobility Group Proteins - pharmacology HMGB1 Protein Humans Phosphorylation Protein Kinase C - metabolism Rats Recombinant Proteins - pharmacology Repressor Proteins - pharmacology Tumor Cells, Cultured
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