Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

Tie2 belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Gene-targeting analyses of either Ang1 or Tie2 in mice reveal a critical role of Ang1–Tie2 signalling in developmental vascular formation. It remains elusive how the Tie2 signalling pathway pla...

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Veröffentlicht in:	Nature cell biology 2008-05, Vol.10 (5), p.513-526
Hauptverfasser:	Fukuhara, Shigetomo, Sako, Keisuke, Minami, Takashi, Noda, Kazuomi, Kim, Hak Zoo, Kodama, Tatsuhiko, Shibuya, Masabumi, Takakura, Nobuyuki, Koh, Gou Young, Mochizuki, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiopoietin-1 - metabolism Animals Biomedical and Life Sciences Cancer Research Cell Biology Cell interaction Cell Line Cell Movement - physiology Developmental Biology Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium Enzyme Activation Extracellular Matrix - metabolism Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Focal Adhesion Protein-Tyrosine Kinases - metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Profiling Growth factors Humans Intercellular Junctions - metabolism Kinases Life Sciences Localization Mice Molecular Sequence Data Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Oligonucleotide Array Sequence Analysis Physiological aspects Protein kinases Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal transduction Signal Transduction - physiology Stem Cells Vascular endothelial growth factor
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