The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations

The design and synthesis of novel diaryl ether NNRTIs with high levels of antiviral potency is reported. Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-05, Vol.18 (9), p.2959-2966
Hauptverfasser:	Tucker, Thomas J., Saggar, Sandeep, Sisko, John T., Tynebor, Robert M., Williams, Theresa M., Felock, Peter J., Flynn, Jessica A., Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P., Wan, Bang-Lin, Yan, Youwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Binding Sites Biological and medical sciences Crystallography, X-Ray Drug Design Drug Resistance, Viral Ethers - chemistry HIV HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Medical sciences Models, Chemical Mutation Mutations NNRTI Nucleosides - chemistry Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - pharmacology Structure-Activity Relationship Virus Replication - drug effects Virus Replication - physiology
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