Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells

Lectin-like transcript-1 (LLT1) (also named osteoclast inhibitory lectin or CLEC2D) is a ligand for the human NKR-P1A (CD161) receptor, present on NK cells and T cells. To further understand the physiological relevance of this interaction, we developed mAbs against LLT1, characterized the expression...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-05, Vol.180 (10), p.6508-6517
Hauptverfasser:	Rosen, David B, Cao, Wei, Avery, Danielle T, Tangye, Stuart G, Liu, Yong-Jun, Houchins, J. P, Lanier, Lewis L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface - metabolism B-Lymphocytes - metabolism Blotting, Western Cells, Cultured Cytotoxicity, Immunologic - physiology Dendritic Cells - metabolism Flow Cytometry Fluorescent Antibody Technique Gene Expression Humans Immunologic Memory - physiology Killer Cells, Natural - metabolism Lectins, C-Type - metabolism Ligands Lymphocyte Activation - immunology NK Cell Lectin-Like Receptor Subfamily B Oligonucleotide Array Sequence Analysis Receptor Cross-Talk - immunology Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes - metabolism Toll-Like Receptors - metabolism
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