Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia
Abstract Objective Patients must remain immobile for magnetoencephalography (MEG) and MRI recordings to allow precise localization of brain function for pre-surgical functional mapping. In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper...
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| Veröffentlicht in: | Clinical neurophysiology 2008-06, Vol.119 (6), p.1328-1334 |
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| creator | Bercovici, Eduard Pang, Elizabeth W Sharma, Rohit Mohamed, Ismail S Imai, Katsumi Fujimoto, Ayataka Ochi, Ayako Viljoen, Amrita Chu, Bill Holowka, Stephanie Chuang, Sylvester H Kemp, Sheelagh M Rutka, James T Carter Snead, O Otsubo, Hiroshi |
| description | Abstract Objective Patients must remain immobile for magnetoencephalography (MEG) and MRI recordings to allow precise localization of brain function for pre-surgical functional mapping. In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA). Methods We investigated the latency, amplitude, residual error (RE) and location of the N20m of the SEF in 26 infants (mean age = 2.6 years). Seventeen patients underwent TIVA and 9 patients were tested while asleep, without TIVA. Results MEG detected 44 reliable SEFs (77%) in 52 median nerve stimulations. We found 27 reliable SEFs (79%) with TIVA and 13 reliable SEFs (72%) without TIVA. TIVA effects included longer latencies ( p < 0.001) and lower RE ( p < 0.05) compared to those without TIVA. Older patients and larger head circumferences also showed significantly shorter latencies ( p < 0.01). Conclusions TIVA resulted in reliable SEFs with lower RE and longer latencies. Significance MEG can detect reliable SEFs in infants younger than 4 years old. When infants require TIVA for MEG and MRI acquisition, SEFs can still be reliably observed. |
| doi_str_mv | 10.1016/j.clinph.2008.02.018 |
| format | Article |
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In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA). Methods We investigated the latency, amplitude, residual error (RE) and location of the N20m of the SEF in 26 infants (mean age = 2.6 years). Seventeen patients underwent TIVA and 9 patients were tested while asleep, without TIVA. Results MEG detected 44 reliable SEFs (77%) in 52 median nerve stimulations. We found 27 reliable SEFs (79%) with TIVA and 13 reliable SEFs (72%) without TIVA. TIVA effects included longer latencies ( p < 0.001) and lower RE ( p < 0.05) compared to those without TIVA. Older patients and larger head circumferences also showed significantly shorter latencies ( p < 0.01). Conclusions TIVA resulted in reliable SEFs with lower RE and longer latencies. Significance MEG can detect reliable SEFs in infants younger than 4 years old. When infants require TIVA for MEG and MRI acquisition, SEFs can still be reliably observed.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2008.02.018</identifier><identifier>PMID: 18406202</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Anesthesia - methods ; Anesthesia, Intravenous - methods ; Biological and medical sciences ; Brain Mapping ; Chi-Square Distribution ; Child, Preschool ; Electric Stimulation - methods ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - physiopathology ; Evoked Potentials, Somatosensory - drug effects ; Evoked Potentials, Somatosensory - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Infant ; Infants ; Magnetoencephalography ; Magnetoencephalography (MEG) ; Male ; Median Nerve - physiopathology ; Median Nerve - radiation effects ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Reaction Time ; Sleep. Vigilance ; Somatosensory-evoked fields (SEF) ; Total intravenous anesthesia (TIVA) ; Vertebrates: nervous system and sense organs</subject><ispartof>Clinical neurophysiology, 2008-06, Vol.119 (6), p.1328-1334</ispartof><rights>International Federation of Clinical Neurophysiology</rights><rights>2008 International Federation of Clinical Neurophysiology</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-25a91137ffb38b199159b768df844a88f37b82d51882337c3acfb3ea947cff573</citedby><cites>FETCH-LOGICAL-c445t-25a91137ffb38b199159b768df844a88f37b82d51882337c3acfb3ea947cff573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2008.02.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20365569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18406202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bercovici, Eduard</creatorcontrib><creatorcontrib>Pang, Elizabeth W</creatorcontrib><creatorcontrib>Sharma, Rohit</creatorcontrib><creatorcontrib>Mohamed, Ismail S</creatorcontrib><creatorcontrib>Imai, Katsumi</creatorcontrib><creatorcontrib>Fujimoto, Ayataka</creatorcontrib><creatorcontrib>Ochi, Ayako</creatorcontrib><creatorcontrib>Viljoen, Amrita</creatorcontrib><creatorcontrib>Chu, Bill</creatorcontrib><creatorcontrib>Holowka, Stephanie</creatorcontrib><creatorcontrib>Chuang, Sylvester H</creatorcontrib><creatorcontrib>Kemp, Sheelagh M</creatorcontrib><creatorcontrib>Rutka, James T</creatorcontrib><creatorcontrib>Carter Snead, O</creatorcontrib><creatorcontrib>Otsubo, Hiroshi</creatorcontrib><title>Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>Abstract Objective Patients must remain immobile for magnetoencephalography (MEG) and MRI recordings to allow precise localization of brain function for pre-surgical functional mapping. In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA). Methods We investigated the latency, amplitude, residual error (RE) and location of the N20m of the SEF in 26 infants (mean age = 2.6 years). Seventeen patients underwent TIVA and 9 patients were tested while asleep, without TIVA. Results MEG detected 44 reliable SEFs (77%) in 52 median nerve stimulations. We found 27 reliable SEFs (79%) with TIVA and 13 reliable SEFs (72%) without TIVA. TIVA effects included longer latencies ( p < 0.001) and lower RE ( p < 0.05) compared to those without TIVA. Older patients and larger head circumferences also showed significantly shorter latencies ( p < 0.01). Conclusions TIVA resulted in reliable SEFs with lower RE and longer latencies. Significance MEG can detect reliable SEFs in infants younger than 4 years old. When infants require TIVA for MEG and MRI acquisition, SEFs can still be reliably observed.</description><subject>Analysis of Variance</subject><subject>Anesthesia - methods</subject><subject>Anesthesia, Intravenous - methods</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Chi-Square Distribution</subject><subject>Child, Preschool</subject><subject>Electric Stimulation - methods</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - physiopathology</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Magnetoencephalography</subject><subject>Magnetoencephalography (MEG)</subject><subject>Male</subject><subject>Median Nerve - physiopathology</subject><subject>Median Nerve - radiation effects</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Reaction Time</subject><subject>Sleep. Vigilance</subject><subject>Somatosensory-evoked fields (SEF)</subject><subject>Total intravenous anesthesia (TIVA)</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkrGO1DAQhiME4u4W3gAhN9Al2E4cOw0SOgGHdBLFQW05znjjvawdbGdRSt4cR7sCiYbKLr75Z_TNFMUrgiuCSfvuUOnJunmsKMaiwrTCRDwprongtBQdo0_zvxaipA3jV8VNjAeMMccNfV5cEdHglmJ6Xfx68EeVfAQXfVhLOPlHGJCxMA0ReYeOau8geXAa5lFNfh_UPK7I-IBgthPMcUXWGeVSRKtf3B4CSqNyqEErqBDRT5tGlHxSU-ZSUCdwfolIOYhphGjVi-KZUVOEl5d3V3z_9PHb7V15__Xzl9sP96VuGpZKylRHSM2N6WvRk64jrOt5KwYjmkYJYWreCzowIgSta65rpTMJqmu4Nobxele8PefOwf9Ycnd5tFHDNOVR8kSy7QinLLfYFc0Z1MHHGMDIOdijCqskWG7q5UGe1ctNvcRUZvW57PUlf-mPMPwturjOwJsLoKJWkwnKaRv_cBTXLWNtl7n3Zw6yjZOFIKO22wIGG0AnOXj7v0n-Ddggm3s-wgrx4JfgsmlJZMwF8mE7k-1KsMCYsKzqN-C0vAc</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Bercovici, Eduard</creator><creator>Pang, Elizabeth W</creator><creator>Sharma, Rohit</creator><creator>Mohamed, Ismail S</creator><creator>Imai, Katsumi</creator><creator>Fujimoto, Ayataka</creator><creator>Ochi, Ayako</creator><creator>Viljoen, Amrita</creator><creator>Chu, Bill</creator><creator>Holowka, Stephanie</creator><creator>Chuang, Sylvester H</creator><creator>Kemp, Sheelagh M</creator><creator>Rutka, James T</creator><creator>Carter Snead, O</creator><creator>Otsubo, Hiroshi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia</title><author>Bercovici, Eduard ; Pang, Elizabeth W ; Sharma, Rohit ; Mohamed, Ismail S ; Imai, Katsumi ; Fujimoto, Ayataka ; Ochi, Ayako ; Viljoen, Amrita ; Chu, Bill ; Holowka, Stephanie ; Chuang, Sylvester H ; Kemp, Sheelagh M ; Rutka, James T ; Carter Snead, O ; Otsubo, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-25a91137ffb38b199159b768df844a88f37b82d51882337c3acfb3ea947cff573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Anesthesia - methods</topic><topic>Anesthesia, Intravenous - methods</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Chi-Square Distribution</topic><topic>Child, Preschool</topic><topic>Electric Stimulation - methods</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - physiopathology</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Magnetoencephalography</topic><topic>Magnetoencephalography (MEG)</topic><topic>Male</topic><topic>Median Nerve - physiopathology</topic><topic>Median Nerve - radiation effects</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Reaction Time</topic><topic>Sleep. Vigilance</topic><topic>Somatosensory-evoked fields (SEF)</topic><topic>Total intravenous anesthesia (TIVA)</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bercovici, Eduard</creatorcontrib><creatorcontrib>Pang, Elizabeth W</creatorcontrib><creatorcontrib>Sharma, Rohit</creatorcontrib><creatorcontrib>Mohamed, Ismail S</creatorcontrib><creatorcontrib>Imai, Katsumi</creatorcontrib><creatorcontrib>Fujimoto, Ayataka</creatorcontrib><creatorcontrib>Ochi, Ayako</creatorcontrib><creatorcontrib>Viljoen, Amrita</creatorcontrib><creatorcontrib>Chu, Bill</creatorcontrib><creatorcontrib>Holowka, Stephanie</creatorcontrib><creatorcontrib>Chuang, Sylvester H</creatorcontrib><creatorcontrib>Kemp, Sheelagh M</creatorcontrib><creatorcontrib>Rutka, James T</creatorcontrib><creatorcontrib>Carter Snead, O</creatorcontrib><creatorcontrib>Otsubo, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bercovici, Eduard</au><au>Pang, Elizabeth W</au><au>Sharma, Rohit</au><au>Mohamed, Ismail S</au><au>Imai, Katsumi</au><au>Fujimoto, Ayataka</au><au>Ochi, Ayako</au><au>Viljoen, Amrita</au><au>Chu, Bill</au><au>Holowka, Stephanie</au><au>Chuang, Sylvester H</au><au>Kemp, Sheelagh M</au><au>Rutka, James T</au><au>Carter Snead, O</au><au>Otsubo, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>119</volume><issue>6</issue><spage>1328</spage><epage>1334</epage><pages>1328-1334</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>Abstract Objective Patients must remain immobile for magnetoencephalography (MEG) and MRI recordings to allow precise localization of brain function for pre-surgical functional mapping. In young children with epilepsy, this is accomplished with recordings during sleep or with anesthesia. This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA). Methods We investigated the latency, amplitude, residual error (RE) and location of the N20m of the SEF in 26 infants (mean age = 2.6 years). Seventeen patients underwent TIVA and 9 patients were tested while asleep, without TIVA. Results MEG detected 44 reliable SEFs (77%) in 52 median nerve stimulations. We found 27 reliable SEFs (79%) with TIVA and 13 reliable SEFs (72%) without TIVA. TIVA effects included longer latencies ( p < 0.001) and lower RE ( p < 0.05) compared to those without TIVA. Older patients and larger head circumferences also showed significantly shorter latencies ( p < 0.01). Conclusions TIVA resulted in reliable SEFs with lower RE and longer latencies. Significance MEG can detect reliable SEFs in infants younger than 4 years old. When infants require TIVA for MEG and MRI acquisition, SEFs can still be reliably observed.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18406202</pmid><doi>10.1016/j.clinph.2008.02.018</doi><tpages>7</tpages></addata></record> |
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| subjects | Analysis of Variance Anesthesia - methods Anesthesia, Intravenous - methods Biological and medical sciences Brain Mapping Chi-Square Distribution Child, Preschool Electric Stimulation - methods Epilepsy Epilepsy - diagnosis Epilepsy - physiopathology Evoked Potentials, Somatosensory - drug effects Evoked Potentials, Somatosensory - physiology Female Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Infant Infants Magnetoencephalography Magnetoencephalography (MEG) Male Median Nerve - physiopathology Median Nerve - radiation effects Medical sciences Nervous system (semeiology, syndromes) Neurology Reaction Time Sleep. Vigilance Somatosensory-evoked fields (SEF) Total intravenous anesthesia (TIVA) Vertebrates: nervous system and sense organs |
| title | Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia |
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