Mathematical modeling and application of genetic algorithm to parameter estimation in signal transduction: Trafficking and promiscuous coupling of G-protein coupled receptors

Abstract G-protein-coupled receptors (GPCRs) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. These receptors play a critical role in signal transduction, and are among the most important pharmacological drug t...

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Veröffentlicht in:	Computers in biology and medicine 2008-05, Vol.38 (5), p.574-582
Hauptverfasser:	Modchang, Charin, Triampo, Wannapong, Lenbury, Yongwimon
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms G-protein coupled receptors Genetic algorithm Humans Internal Medicine Models, Biological Other Promiscuous coupling Protein Transport Receptors, G-Protein-Coupled - physiology Signal Transduction Trafficking
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