Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth

Bisphosphonates (BPs) are effective inhibitors of tumor-induced bone resorption. Recent studies have demonstrated that BPs inhibit growth, attachment and invasion of cancer cells in culture and promote apoptosis. The mechanisms responsible for the observed anti-tumor effects of BPs are beginning to...

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Veröffentlicht in:	Anti-cancer drugs 2008-04, Vol.19 (4), p.391-399
Hauptverfasser:	Mönkkönen, Hannu, Kuokkanen, Johanna, Holen, Ingunn, Evans, Alyson, Lefley, Diane V, Jauhiainen, Marjo, Auriola, Seppo, Mönkkönen, Jukka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - biosynthesis Amino Acyl-tRNA Synthetases - metabolism Apoptosis - drug effects Blotting, Western Bone Density Conservation Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Clodronic Acid - pharmacology Diphosphonates - pharmacology Geranyltranstransferase - metabolism Hemiterpenes - biosynthesis Humans Imidazoles - pharmacology Organophosphorus Compounds Protein Prenylation - drug effects rap1 GTP-Binding Proteins - metabolism
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