First report of Cryptococcus laurentii meningitis and a fatal case of cryptococcus albidus cryptococcaemia in AIDS patients
We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infectio...
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| Veröffentlicht in: | Medical mycology (Oxford) 1998-10, Vol.36 (5), p.335-339 |
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| container_title | Medical mycology (Oxford) |
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| creator | KORDOSSIS, T AVLAMI, A VELEGRAKI, A STEFANOU, I GEORGAKOPOULOS, G PAPALAMBROU, C LEGAKIS, N. J |
| description | We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infection 20 months later. The patient with C. albidus cryptococcaemia, despite the amphotericin B/flucytosine combination therapy, died on the 14th day of treatment. The minimum inhibitory concentrations (MICs) for C. laurentii, as determined by Etest on RPMI 1640 agar, were 0.25 microg ml(-1) of amphotericin B, 1.25 microg ml(-1) flucytosine, 4 microg ml(-1) fluconazole, 0.50 microg ml(-1) itraconazole and 1.0 microg ml(-1) of ketoconazole. The MIC of amphotericin B for C. albidus was 0.5 microg ml(-1), flucytosine 1.25 microg ml(-1), fluzonazole 4 microg ml(-1), itraconazole 0.5 microg ml(-1) and ketonazole 0.25 microg ml(-1). The agreement of the amphotericin B MIC values obtained in antibiotic medium 3 by the broth microdilution method, with those obtained on casitone medium by Etest, was within a two-dilution range for both isolates. C. laurentii may cause meningitis and may also involve the lungs in AIDS patients. |
| doi_str_mv | 10.1046/j.1365-280x.1998.00166.x |
| format | Article |
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J</creator><creatorcontrib>KORDOSSIS, T ; AVLAMI, A ; VELEGRAKI, A ; STEFANOU, I ; GEORGAKOPOULOS, G ; PAPALAMBROU, C ; LEGAKIS, N. J</creatorcontrib><description>We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infection 20 months later. The patient with C. albidus cryptococcaemia, despite the amphotericin B/flucytosine combination therapy, died on the 14th day of treatment. The minimum inhibitory concentrations (MICs) for C. laurentii, as determined by Etest on RPMI 1640 agar, were 0.25 microg ml(-1) of amphotericin B, 1.25 microg ml(-1) flucytosine, 4 microg ml(-1) fluconazole, 0.50 microg ml(-1) itraconazole and 1.0 microg ml(-1) of ketoconazole. The MIC of amphotericin B for C. albidus was 0.5 microg ml(-1), flucytosine 1.25 microg ml(-1), fluzonazole 4 microg ml(-1), itraconazole 0.5 microg ml(-1) and ketonazole 0.25 microg ml(-1). The agreement of the amphotericin B MIC values obtained in antibiotic medium 3 by the broth microdilution method, with those obtained on casitone medium by Etest, was within a two-dilution range for both isolates. 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J</creatorcontrib><title>First report of Cryptococcus laurentii meningitis and a fatal case of cryptococcus albidus cryptococcaemia in AIDS patients</title><title>Medical mycology (Oxford)</title><addtitle>Med Mycol</addtitle><description>We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infection 20 months later. The patient with C. albidus cryptococcaemia, despite the amphotericin B/flucytosine combination therapy, died on the 14th day of treatment. The minimum inhibitory concentrations (MICs) for C. laurentii, as determined by Etest on RPMI 1640 agar, were 0.25 microg ml(-1) of amphotericin B, 1.25 microg ml(-1) flucytosine, 4 microg ml(-1) fluconazole, 0.50 microg ml(-1) itraconazole and 1.0 microg ml(-1) of ketoconazole. The MIC of amphotericin B for C. albidus was 0.5 microg ml(-1), flucytosine 1.25 microg ml(-1), fluzonazole 4 microg ml(-1), itraconazole 0.5 microg ml(-1) and ketonazole 0.25 microg ml(-1). The agreement of the amphotericin B MIC values obtained in antibiotic medium 3 by the broth microdilution method, with those obtained on casitone medium by Etest, was within a two-dilution range for both isolates. 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The minimum inhibitory concentrations (MICs) for C. laurentii, as determined by Etest on RPMI 1640 agar, were 0.25 microg ml(-1) of amphotericin B, 1.25 microg ml(-1) flucytosine, 4 microg ml(-1) fluconazole, 0.50 microg ml(-1) itraconazole and 1.0 microg ml(-1) of ketoconazole. The MIC of amphotericin B for C. albidus was 0.5 microg ml(-1), flucytosine 1.25 microg ml(-1), fluzonazole 4 microg ml(-1), itraconazole 0.5 microg ml(-1) and ketonazole 0.25 microg ml(-1). The agreement of the amphotericin B MIC values obtained in antibiotic medium 3 by the broth microdilution method, with those obtained on casitone medium by Etest, was within a two-dilution range for both isolates. C. laurentii may cause meningitis and may also involve the lungs in AIDS patients.</abstract><cop>Abingdon</cop><pub>Taylor & Francis</pub><pmid>10075504</pmid><doi>10.1046/j.1365-280x.1998.00166.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1369-3786 |
| ispartof | Medical mycology (Oxford), 1998-10, Vol.36 (5), p.335-339 |
| issn | 1369-3786 1460-2709 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Taylor & Francis Journals Complete |
| subjects | Adult AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - microbiology AIDS/HIV Amphotericin B - therapeutic use Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Biological and medical sciences Cryptococcosis - diagnosis Cryptococcosis - drug therapy Cryptococcus - classification Cryptococcus - drug effects Cryptococcus - isolation & purification Cryptococcus albidus Cryptococcus laurentii Drug Therapy, Combination Fatal Outcome Female Flucytosine - therapeutic use Human mycoses Humans Infectious diseases Male Medical sciences Meningitis - diagnosis Meningitis - drug therapy Meningitis - microbiology Microbial Sensitivity Tests Middle Aged Mycoses Mycoses of the nervous system |
| title | First report of Cryptococcus laurentii meningitis and a fatal case of cryptococcus albidus cryptococcaemia in AIDS patients |
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