The Potential Role of Doxycycline in the Treatment of Osteoarthritis of the Temporomandibular Joint

Collagenase and gelatinase are matrix metalloproteinases (MMPs) which play an important role in tissue destruction in arthritic joints. Studies have demonstrated that tetracyclines can inhibit MMPs and prevent tissue destruction independent of their antimicrobial activity. The purpose of this pilot...

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Veröffentlicht in:	Advances in dental research 1998-11, Vol.12 (1), p.51-55
Hauptverfasser:	Israel, H.A., Ramamiurthy, N.S., Greenwald, R., Golub, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Collagenases - metabolism Dentistry Doxycycline - pharmacology Doxycycline - therapeutic use Female Gelatinases - antagonists & inhibitors Gelatinases - metabolism Humans Matrix Metalloproteinase Inhibitors Osteoarthritis - drug therapy Osteoarthritis - enzymology Pilot Projects Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Synovial Fluid - enzymology Temporomandibular Joint Disorders - drug therapy Temporomandibular Joint Disorders - enzymology
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