Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

Tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We generated cell lines from glioblastoma specimens with the goal to obtain model systems for glioma stem cell biology. Unsupervised analysis of...

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Veröffentlicht in:	Oncogene 2008-05, Vol.27 (20), p.2897-2909
Hauptverfasser:	Günther, H S, Schmidt, N O, Phillips, H S, Kemming, D, Kharbanda, S, Soriano, R, Modrusan, Z, Meissner, H, Westphal, M, Lamszus, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Apoptosis Biological and medical sciences Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cell Biology Cell culture Cell Culture Techniques Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA microarrays Extracellular matrix Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioma Glioma cells Health aspects Human Genetics Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Mice Mice, Nude Middle Aged Molecular and cellular biology Neoplastic Stem Cells - classification Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Neural stem cells Neurology Oncology original-article Phenotype Phenotypes Risk factors Stem cells Therapeutic targets Tumor cells Tumor Cells, Cultured Tumorigenicity Tumors of the nervous system. Phacomatoses
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