Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia

Functional loss of CCAAT/enhancer binding protein alpha (C/EBP alpha), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here, we show the effect of epigenetic aberrations in r...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-05, Vol.68 (9), p.3142-3151
Hauptverfasser:	Hackanson, Björn, Bennett, Kristi L, Brena, Romulo M, Jiang, Jinmai, Claus, Rainer, Chen, Shih-Shih, Blagitko-Dorfs, Nadya, Maharry, Katie, Whitman, Susan P, Schmittgen, Thomas D, Lübbert, Michael, Marcucci, Guido, Bloomfield, Clara D, Plass, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Cluster Analysis Cytogenetic Analysis DNA Methylation Epigenesis, Genetic Gene Expression Regulation, Leukemic Hematopoiesis - genetics HL-60 Cells Humans K562 Cells Leukemia, Myeloid, Acute - classification Leukemia, Myeloid, Acute - genetics MicroRNAs - physiology Promoter Regions, Genetic RNA Interference RNA, Messenger - metabolism Tumor Cells, Cultured U937 Cells
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