Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea
In this report, we presented the results that EGCG, the main constituent of the polyphenols present in Japanese green tea inhibited growth of leukemic cell lines of both human and mice. The proliferation of human leukemic cell lines and mouse NFS60 cell line was inhibited by EGCG. Sensitivity of eac...
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| Veröffentlicht in: | Life sciences (1973) 1998, Vol.63 (16), p.1397-1403 |
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| container_title | Life sciences (1973) |
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| creator | Otsuka, Takeshi Ogo, Tomonori Eto, Tetsuya Asano, Yoshinobu Suganuma, Masami Niho, Yoshiyuki |
| description | In this report, we presented the results that EGCG, the main constituent of the polyphenols present in Japanese green tea inhibited growth of leukemic cell lines of both human and mice. The proliferation of human leukemic cell lines and mouse NFS60 cell line was inhibited by EGCG. Sensitivity of each line to EGCG was different, and more than 50% of DNA systhesis was reduced in all the cell lines in the presence of 50 μM EGCG. On the other hand, normal hematopoietic progenitor cells retained their natural function of supplying mature cells of various lineages in the presence of less than 10 μM EGCG
in vitro. Even in the presence of 100 μM EGCG, half the colonies containing all the lineages of cells were developed. All the dead cells of each line showed characteristics of apoptosis, which might be due to inhibition by EGCG of growth factors' signaling. Besides anticarcinogenic activity, EGCG is expected to have a new function for leukemia therapy without side effects. |
| doi_str_mv | 10.1016/S0024-3205(98)00406-8 |
| format | Article |
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in vitro. Even in the presence of 100 μM EGCG, half the colonies containing all the lineages of cells were developed. All the dead cells of each line showed characteristics of apoptosis, which might be due to inhibition by EGCG of growth factors' signaling. Besides anticarcinogenic activity, EGCG is expected to have a new function for leukemia therapy without side effects.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(98)00406-8</identifier><identifier>PMID: 9952285</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; apoptosis ; Apoptosis - drug effects ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Cell Division - drug effects ; Cell Lineage - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; DNA - biosynthesis ; DNA Fragmentation - drug effects ; EGCG ; Granulocyte Colony-Stimulating Factor - pharmacology ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - drug effects ; Humans ; Interleukin-3 - pharmacology ; Leukemia - drug therapy ; Leukemia - pathology ; leukemic cells ; Mice ; Tea - chemistry ; Tumor Cells, Cultured</subject><ispartof>Life sciences (1973), 1998, Vol.63 (16), p.1397-1403</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-62dc16112eef8faaf2876c98c8c3c61534e20cda9466ecd0d61935025781bfbf3</citedby><cites>FETCH-LOGICAL-c426t-62dc16112eef8faaf2876c98c8c3c61534e20cda9466ecd0d61935025781bfbf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(98)00406-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4021,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9952285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otsuka, Takeshi</creatorcontrib><creatorcontrib>Ogo, Tomonori</creatorcontrib><creatorcontrib>Eto, Tetsuya</creatorcontrib><creatorcontrib>Asano, Yoshinobu</creatorcontrib><creatorcontrib>Suganuma, Masami</creatorcontrib><creatorcontrib>Niho, Yoshiyuki</creatorcontrib><title>Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>In this report, we presented the results that EGCG, the main constituent of the polyphenols present in Japanese green tea inhibited growth of leukemic cell lines of both human and mice. The proliferation of human leukemic cell lines and mouse NFS60 cell line was inhibited by EGCG. Sensitivity of each line to EGCG was different, and more than 50% of DNA systhesis was reduced in all the cell lines in the presence of 50 μM EGCG. On the other hand, normal hematopoietic progenitor cells retained their natural function of supplying mature cells of various lineages in the presence of less than 10 μM EGCG
in vitro. Even in the presence of 100 μM EGCG, half the colonies containing all the lineages of cells were developed. All the dead cells of each line showed characteristics of apoptosis, which might be due to inhibition by EGCG of growth factors' signaling. Besides anticarcinogenic activity, EGCG is expected to have a new function for leukemia therapy without side effects.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cell Lineage - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>DNA - biosynthesis</subject><subject>DNA Fragmentation - drug effects</subject><subject>EGCG</subject><subject>Granulocyte Colony-Stimulating Factor - pharmacology</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Humans</subject><subject>Interleukin-3 - pharmacology</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - pathology</subject><subject>leukemic cells</subject><subject>Mice</subject><subject>Tea - chemistry</subject><subject>Tumor Cells, Cultured</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1u1TAQhS0Eai-FR6jkVdVKBGwnduwVqiooSJVY0K4tZzJpTJP41nZa9Q1Y84g8CUnvVbes5u_MGc1HyDFnHznj6tNPxkRVlILJU6PPGKuYKvQrsuG6NgVTJX9NNi-SQ_I2pV-MMSnr8oAcGCOF0HJD-ssYHnNP_dT7xmcfJho6OuB8h6MHCjgMiTZP9PTv7z9nBW79rRuGAC4j9H6ia7XkH2jukY5u6UCYUvZ5ximvTrcRcaIZ3TvypnNDwvf7eERuvn65vvhWXP24_H5xflVAJVQulGiBK84FYqc75zqhawVGg4YSFJdlhYJB60ylFELLWsVNKZmQteZN13TlETnZ-W5juJ8xZTv6tL7hJgxzsspwJeu6XIRyJ4QYUorY2W30o4tPljO7ErbPhO2Kzxptnwlbvewd7w_MzYjty9Ye6TL_vJvj8uWDx2gTeJwAWx8Rsm2D_8-Ff3DajHI</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Otsuka, Takeshi</creator><creator>Ogo, Tomonori</creator><creator>Eto, Tetsuya</creator><creator>Asano, Yoshinobu</creator><creator>Suganuma, Masami</creator><creator>Niho, Yoshiyuki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea</title><author>Otsuka, Takeshi ; Ogo, Tomonori ; Eto, Tetsuya ; Asano, Yoshinobu ; Suganuma, Masami ; Niho, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-62dc16112eef8faaf2876c98c8c3c61534e20cda9466ecd0d61935025781bfbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cell Lineage - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>DNA - biosynthesis</topic><topic>DNA Fragmentation - drug effects</topic><topic>EGCG</topic><topic>Granulocyte Colony-Stimulating Factor - pharmacology</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Humans</topic><topic>Interleukin-3 - pharmacology</topic><topic>Leukemia - drug therapy</topic><topic>Leukemia - pathology</topic><topic>leukemic cells</topic><topic>Mice</topic><topic>Tea - chemistry</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otsuka, Takeshi</creatorcontrib><creatorcontrib>Ogo, Tomonori</creatorcontrib><creatorcontrib>Eto, Tetsuya</creatorcontrib><creatorcontrib>Asano, Yoshinobu</creatorcontrib><creatorcontrib>Suganuma, Masami</creatorcontrib><creatorcontrib>Niho, Yoshiyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otsuka, Takeshi</au><au>Ogo, Tomonori</au><au>Eto, Tetsuya</au><au>Asano, Yoshinobu</au><au>Suganuma, Masami</au><au>Niho, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1998</date><risdate>1998</risdate><volume>63</volume><issue>16</issue><spage>1397</spage><epage>1403</epage><pages>1397-1403</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>In this report, we presented the results that EGCG, the main constituent of the polyphenols present in Japanese green tea inhibited growth of leukemic cell lines of both human and mice. The proliferation of human leukemic cell lines and mouse NFS60 cell line was inhibited by EGCG. Sensitivity of each line to EGCG was different, and more than 50% of DNA systhesis was reduced in all the cell lines in the presence of 50 μM EGCG. On the other hand, normal hematopoietic progenitor cells retained their natural function of supplying mature cells of various lineages in the presence of less than 10 μM EGCG
in vitro. Even in the presence of 100 μM EGCG, half the colonies containing all the lineages of cells were developed. All the dead cells of each line showed characteristics of apoptosis, which might be due to inhibition by EGCG of growth factors' signaling. Besides anticarcinogenic activity, EGCG is expected to have a new function for leukemia therapy without side effects.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9952285</pmid><doi>10.1016/S0024-3205(98)00406-8</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Catechin - analogs & derivatives Catechin - pharmacology Cell Division - drug effects Cell Lineage - drug effects Cell Survival - drug effects Cells, Cultured DNA - biosynthesis DNA Fragmentation - drug effects EGCG Granulocyte Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humans Interleukin-3 - pharmacology Leukemia - drug therapy Leukemia - pathology leukemic cells Mice Tea - chemistry Tumor Cells, Cultured |
| title | Growth inhibition of leukemic cells by (−)-epigallocatechin gallate, the main constituent of green tea |
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