Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers
Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers Hirofumi Yasue, Yuji Mizuno, Eisaku Harada, Teruhiko Itoh, Hitoshi Nakagawa, Masafumi Nakayama, Hisao Ogawa, Shinji Tayama, Takasi Honda, Seiji Hokimoto...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-05, Vol.51 (18), p.1742-1748 |
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| creator | Yasue, Hirofumi, MD Mizuno, Yuji, MD Harada, Eisaku, MD Itoh, Teruhiko, MD Nakagawa, Hitoshi, MD Nakayama, Masafumi, MD Ogawa, Hisao, MD Tayama, Shinji, MD Honda, Takasi, MD Hokimoto, Seiji, MD Ohshima, Shuichi, MD Hokamura, Youichi, MD Kugiyama, Kiyotaka, MD Horie, Minoru, MD Yoshimura, Michihiro, MD Harada, Masaki, MD Uemura, Shiroh, MD Saito, Yoshihiko, MD |
| description | Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers Hirofumi Yasue, Yuji Mizuno, Eisaku Harada, Teruhiko Itoh, Hitoshi Nakagawa, Masafumi Nakayama, Hisao Ogawa, Shinji Tayama, Takasi Honda, Seiji Hokimoto, Shuichi Ohshima, Youichi Hokamura, Kiyotaka Kugiyama, Minoru Horie, Michihiro Yoshimura, Masaki Harada, Shiroh Uemura, Yoshihiko Saito, for the SCAST (Statin and Coronary Artery Spasm Trial) Investigators Sixty-four patients in whom coronary spasm was induced by intracoronary injection of acetylcholine were randomly assigned to fluvastatin 30 mg/day plus the conventional therapy (31 patients, statin group) or the conventional therapy (33 patients, nonstatin group) for 6 months of treatment. There was a significant reduction in the number of patients with acetylcholine-induced coronary spasm in the statin group as compared with the nonstatin group after 6 months of treatment (51.6% vs. 21.2%, p = 0.0231). Thus, a statin (fluvastatin) may possibly be used as a novel drug for the treatment of coronary spasm. |
| doi_str_mv | 10.1016/j.jacc.2007.12.049 |
| format | Article |
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There was a significant reduction in the number of patients with acetylcholine-induced coronary spasm in the statin group as compared with the nonstatin group after 6 months of treatment (51.6% vs. 21.2%, p = 0.0231). Thus, a statin (fluvastatin) may possibly be used as a novel drug for the treatment of coronary spasm.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.12.049</identifier><identifier>PMID: 18452779</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylcholine - pharmacology ; Adult ; Aged ; Aged, 80 and over ; Angina pectoris ; Biological and medical sciences ; Calcium Channel Blockers - therapeutic use ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cholesterol ; Coronary Angiography ; Coronary heart disease ; Coronary Vasospasm - drug therapy ; Coronary Vasospasm - physiopathology ; Coronary vessels ; Coronary Vessels - drug effects ; Coronary Vessels - pathology ; Endothelium - drug effects ; Endothelium - physiopathology ; Fatty Acids, Monounsaturated - therapeutic use ; Female ; Heart ; Heart attacks ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Indoles - therapeutic use ; Internal Medicine ; Male ; Medical sciences ; Middle Aged ; Nitric Oxide ; Older people ; Prospective Studies ; Risk Factors ; Treatment Outcome</subject><ispartof>Journal of the American College of Cardiology, 2008-05, Vol.51 (18), p.1742-1748</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 6, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c644t-29da5257a949e4d01b67524c9463c15557475054451cdd994bd2da3d461a961c3</citedby><cites>FETCH-LOGICAL-c644t-29da5257a949e4d01b67524c9463c15557475054451cdd994bd2da3d461a961c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109708006979$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20332735$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18452779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasue, Hirofumi, MD</creatorcontrib><creatorcontrib>Mizuno, Yuji, MD</creatorcontrib><creatorcontrib>Harada, Eisaku, MD</creatorcontrib><creatorcontrib>Itoh, Teruhiko, MD</creatorcontrib><creatorcontrib>Nakagawa, Hitoshi, MD</creatorcontrib><creatorcontrib>Nakayama, Masafumi, MD</creatorcontrib><creatorcontrib>Ogawa, Hisao, MD</creatorcontrib><creatorcontrib>Tayama, Shinji, MD</creatorcontrib><creatorcontrib>Honda, Takasi, MD</creatorcontrib><creatorcontrib>Hokimoto, Seiji, MD</creatorcontrib><creatorcontrib>Ohshima, Shuichi, MD</creatorcontrib><creatorcontrib>Hokamura, Youichi, MD</creatorcontrib><creatorcontrib>Kugiyama, Kiyotaka, MD</creatorcontrib><creatorcontrib>Horie, Minoru, MD</creatorcontrib><creatorcontrib>Yoshimura, Michihiro, MD</creatorcontrib><creatorcontrib>Harada, Masaki, MD</creatorcontrib><creatorcontrib>Uemura, Shiroh, MD</creatorcontrib><creatorcontrib>Saito, Yoshihiko, MD</creatorcontrib><creatorcontrib>SCAST (Statin and Coronary Artery Spasm Trial) Investigators</creatorcontrib><title>Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers Hirofumi Yasue, Yuji Mizuno, Eisaku Harada, Teruhiko Itoh, Hitoshi Nakagawa, Masafumi Nakayama, Hisao Ogawa, Shinji Tayama, Takasi Honda, Seiji Hokimoto, Shuichi Ohshima, Youichi Hokamura, Kiyotaka Kugiyama, Minoru Horie, Michihiro Yoshimura, Masaki Harada, Shiroh Uemura, Yoshihiko Saito, for the SCAST (Statin and Coronary Artery Spasm Trial) Investigators Sixty-four patients in whom coronary spasm was induced by intracoronary injection of acetylcholine were randomly assigned to fluvastatin 30 mg/day plus the conventional therapy (31 patients, statin group) or the conventional therapy (33 patients, nonstatin group) for 6 months of treatment. There was a significant reduction in the number of patients with acetylcholine-induced coronary spasm in the statin group as compared with the nonstatin group after 6 months of treatment (51.6% vs. 21.2%, p = 0.0231). Thus, a statin (fluvastatin) may possibly be used as a novel drug for the treatment of coronary spasm.</description><subject>Acetylcholine - pharmacology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina pectoris</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Coronary Vasospasm - drug therapy</subject><subject>Coronary Vasospasm - physiopathology</subject><subject>Coronary vessels</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - pathology</subject><subject>Endothelium - drug effects</subject><subject>Endothelium - physiopathology</subject><subject>Fatty Acids, Monounsaturated - therapeutic use</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Indoles - therapeutic use</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric Oxide</subject><subject>Older people</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9qFDEYxQdR7Fp9AS8kIHrVWZNMMtlAEdaltYWKYBUvQzbJuNlmkjXJVMfX8IXNsIuFXujVd_M7379zquo5gnMEUftmO99KpeYYQjZHeA4Jf1DNEKWLuqGcPaxmkDW0RpCzo-pJSlsIYbtA_HF1hBaEYsb4rPp91nVG5QRCByRo6otRx_BzrJv6g8mb0X1zQ5ZxdGAVjP819gYswSejB5VlMuDSb-za5hBPwLkbbmXKMlt_AoIvfAy-KMH1TqYeLLtsIvhq80ZH-UO6ad5KOmWHvl5tpPfGgXcuqBsT09PqUSddMs8O9bj6cn72eXVRX318f7laXtWqJSTXmGtJMWWSE26IhmjdMoqJ4qRtVHkDZYRRSAmhSGnNOVlrrGWjSYskb5FqjqvX-767GL4PJmXR26SMc9KbMCTRctQSvkD_BTHElFBOC_jyHrgNQ_TlCIEobDHkiLWFwntKxZBSNJ3YRduXXwkExeSs2IrJWTE5KxAWxdkienFoPax7o-8kBysL8OoAyKSk66L0yqa_HIZNg0seCne650x57a01USRljVdG21iSIHSw_97j7T25ctbbMvHGjCbd3StSEYjrKYNTBOGipI-XPf8AGbPVMA</recordid><startdate>20080506</startdate><enddate>20080506</enddate><creator>Yasue, Hirofumi, MD</creator><creator>Mizuno, Yuji, MD</creator><creator>Harada, Eisaku, MD</creator><creator>Itoh, Teruhiko, MD</creator><creator>Nakagawa, Hitoshi, MD</creator><creator>Nakayama, Masafumi, MD</creator><creator>Ogawa, Hisao, MD</creator><creator>Tayama, Shinji, MD</creator><creator>Honda, Takasi, MD</creator><creator>Hokimoto, Seiji, MD</creator><creator>Ohshima, Shuichi, MD</creator><creator>Hokamura, Youichi, MD</creator><creator>Kugiyama, Kiyotaka, MD</creator><creator>Horie, Minoru, MD</creator><creator>Yoshimura, Michihiro, MD</creator><creator>Harada, Masaki, MD</creator><creator>Uemura, Shiroh, MD</creator><creator>Saito, Yoshihiko, MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20080506</creationdate><title>Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers</title><author>Yasue, Hirofumi, MD ; Mizuno, Yuji, MD ; Harada, Eisaku, MD ; Itoh, Teruhiko, MD ; Nakagawa, Hitoshi, MD ; Nakayama, Masafumi, MD ; Ogawa, Hisao, MD ; Tayama, Shinji, MD ; Honda, Takasi, MD ; Hokimoto, Seiji, MD ; Ohshima, Shuichi, MD ; Hokamura, Youichi, MD ; Kugiyama, Kiyotaka, MD ; Horie, Minoru, MD ; Yoshimura, Michihiro, MD ; Harada, Masaki, MD ; Uemura, Shiroh, MD ; Saito, Yoshihiko, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-29da5257a949e4d01b67524c9463c15557475054451cdd994bd2da3d461a961c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina pectoris</topic><topic>Biological and medical sciences</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Cardiology</topic><topic>Cardiology. 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There was a significant reduction in the number of patients with acetylcholine-induced coronary spasm in the statin group as compared with the nonstatin group after 6 months of treatment (51.6% vs. 21.2%, p = 0.0231). Thus, a statin (fluvastatin) may possibly be used as a novel drug for the treatment of coronary spasm.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18452779</pmid><doi>10.1016/j.jacc.2007.12.049</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2008-05, Vol.51 (18), p.1742-1748 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69164981 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacology Adult Aged Aged, 80 and over Angina pectoris Biological and medical sciences Calcium Channel Blockers - therapeutic use Cardiology Cardiology. Vascular system Cardiovascular Cholesterol Coronary Angiography Coronary heart disease Coronary Vasospasm - drug therapy Coronary Vasospasm - physiopathology Coronary vessels Coronary Vessels - drug effects Coronary Vessels - pathology Endothelium - drug effects Endothelium - physiopathology Fatty Acids, Monounsaturated - therapeutic use Female Heart Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Indoles - therapeutic use Internal Medicine Male Medical sciences Middle Aged Nitric Oxide Older people Prospective Studies Risk Factors Treatment Outcome |
| title | Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T15%3A18%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20a%203-Hydroxy-3-Methylglutaryl%20Coenzyme%20A%20Reductase%20Inhibitor,%20Fluvastatin,%20on%20Coronary%20Spasm%20After%20Withdrawal%20of%20Calcium-Channel%20Blockers&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Yasue,%20Hirofumi,%20MD&rft.aucorp=SCAST%20(Statin%20and%20Coronary%20Artery%20Spasm%20Trial)%20Investigators&rft.date=2008-05-06&rft.volume=51&rft.issue=18&rft.spage=1742&rft.epage=1748&rft.pages=1742-1748&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/j.jacc.2007.12.049&rft_dat=%3Cproquest_cross%3E3242955701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506209176&rft_id=info:pmid/18452779&rft_els_id=S0735109708006979&rfr_iscdi=true |