Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors
The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC 50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. The synthesis and activity of a series of 4,5-diarylimidazole COX-2 inhibitors are d...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (24), p.3443-3448 |
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| container_issue | 24 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Barta, Thomas E. Stealey, Michael A. Collins, Paul W. Weier, Richard M. |
| description | The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC
50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.
The synthesis and activity of a series of 4,5-diarylimidazole COX-2 inhibitors are described. One analog had an IC
50 of 80 nM, was 6750-fold selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. |
| doi_str_mv | 10.1016/S0960-894X(98)00627-1 |
| format | Article |
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50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.
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50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.
The synthesis and activity of a series of 4,5-diarylimidazole COX-2 inhibitors are described. One analog had an IC
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (24), p.3443-3448 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclooxygenase Inhibitors - pharmacology Imidazoles - chemistry Imidazoles - pharmacology Medical sciences Mice Molecular Structure Pharmacology. Drug treatments |
| title | Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors |
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