Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5:7-fused, planar, aromatic heterocyclic ring system

The synthesis of a novel planar, potentially aromatic, ring-expanded xanthine analogue ( 1), containing the 5:7-fused imidazo[4,5-e][1,4]diazepine ring system, along with guanase inhibition studies are reported. The compound was synthesized in six steps, starting from 1-benzyl-5-nitroimidazole-4-car...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-12, Vol.8 (24), p.3649-3652
Hauptverfasser:	Rajappan, Vasanthakumar, Hosmane, Ramachandra S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Guanine Deaminase - antagonists & inhibitors Hydrolases Liver - drug effects Liver - enzymology Rabbits Xanthines - chemical synthesis Xanthines - chemistry Xanthines - pharmacology
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