Natural products as angiogenesis inhibitors
Abstract Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation,...
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| Veröffentlicht in: | Planta medica 1998-12, Vol.64 (8), p.686-695 |
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| container_title | Planta medica |
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| creator | Paper, D.H |
| description | Abstract
Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like basement destruction of blood vessels, proliferation and migration of endothelial cells, or the lumen formation. Among the known angiogenesis inhibitors compounds derived from natural sources, like flavonoids, sulphated carbohydrates, or triterpenoids are playing a prominent role. |
| doi_str_mv | 10.1055/s-2006-957559 |
| format | Article |
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Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like basement destruction of blood vessels, proliferation and migration of endothelial cells, or the lumen formation. Among the known angiogenesis inhibitors compounds derived from natural sources, like flavonoids, sulphated carbohydrates, or triterpenoids are playing a prominent role.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-957559</identifier><identifier>PMID: 9933986</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adult ; Animals ; Biological and medical sciences ; blood vessels ; carbohydrates ; cell differentiation ; drug therapy ; flavonoids ; General pharmacology ; Humans ; inhibitors ; literature reviews ; Medical sciences ; medicinal properties ; membranes ; metabolites ; Molecular Structure ; neoplasms ; Neovascularization, Pathologic - drug therapy ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; plant proteins ; plants ; Review ; triterpenoids</subject><ispartof>Planta medica, 1998-12, Vol.64 (8), p.686-695</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-1f483eef0e69d7077964e1969c6353c81ea66154f28c575222ab3a6a57cac9ca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-957559.pdf$$EPDF$$P50$$Gthieme$$Hfree_for_read</linktopdf><link.rule.ids>314,776,780,3004,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1667778$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9933986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paper, D.H</creatorcontrib><title>Natural products as angiogenesis inhibitors</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like basement destruction of blood vessels, proliferation and migration of endothelial cells, or the lumen formation. Among the known angiogenesis inhibitors compounds derived from natural sources, like flavonoids, sulphated carbohydrates, or triterpenoids are playing a prominent role.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood vessels</subject><subject>carbohydrates</subject><subject>cell differentiation</subject><subject>drug therapy</subject><subject>flavonoids</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>inhibitors</subject><subject>literature reviews</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>membranes</subject><subject>metabolites</subject><subject>Molecular Structure</subject><subject>neoplasms</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>plant proteins</subject><subject>plants</subject><subject>Review</subject><subject>triterpenoids</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EglIYGREdEAsEznZi50aE-JIqGIDZurpOcZUmxU4G_j2uUsGEdNI73KP3Tg9jJxyuORTFTcwEgMqw0EWBO2zEc4kZCMF32QhAigwwlwfsMMYlAM8RYJ_tI0qJpRqxyxfq-kD1ZB3aeW-7OKE0zcK3C9e46OPEN59-5rs2xCO2V1Ed3fE2x-zj4f797imbvj4-391OM5uXsst4lcK5CpzCuQatUeWOo0KrZCFtyR0pxYu8EqVNTwshaCZJUaEtWbQkx-xi6E0_ffUudmblo3V1TY1r-2gUcpXzXCcwG0Ab2hiDq8w6-BWFb8PBbOSYaDZyzCAn8afb4n62cvNfemsj7c-3e4qW6ipQY338K1VKa10m7GrAuk_vVs4s2z40Sci_V88GvKLW0CKkxo83AVyCKFEiCvkDsGuBqw</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Paper, D.H</creator><general>Thieme</general><scope>FBQ</scope><scope>0U6</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Natural products as angiogenesis inhibitors</title><author>Paper, D.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-1f483eef0e69d7077964e1969c6353c81ea66154f28c575222ab3a6a57cac9ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood vessels</topic><topic>carbohydrates</topic><topic>cell differentiation</topic><topic>drug therapy</topic><topic>flavonoids</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>inhibitors</topic><topic>literature reviews</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>membranes</topic><topic>metabolites</topic><topic>Molecular Structure</topic><topic>neoplasms</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>plant proteins</topic><topic>plants</topic><topic>Review</topic><topic>triterpenoids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paper, D.H</creatorcontrib><collection>AGRIS</collection><collection>Thieme Connect Journals Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paper, D.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural products as angiogenesis inhibitors</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>64</volume><issue>8</issue><spage>686</spage><epage>695</epage><pages>686-695</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like basement destruction of blood vessels, proliferation and migration of endothelial cells, or the lumen formation. Among the known angiogenesis inhibitors compounds derived from natural sources, like flavonoids, sulphated carbohydrates, or triterpenoids are playing a prominent role.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>9933986</pmid><doi>10.1055/s-2006-957559</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-0943 |
| ispartof | Planta medica, 1998-12, Vol.64 (8), p.686-695 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Animals Biological and medical sciences blood vessels carbohydrates cell differentiation drug therapy flavonoids General pharmacology Humans inhibitors literature reviews Medical sciences medicinal properties membranes metabolites Molecular Structure neoplasms Neovascularization, Pathologic - drug therapy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - therapeutic use plant proteins plants Review triterpenoids |
| title | Natural products as angiogenesis inhibitors |
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