Partitioning of Anti-inflammatory Steroid Drugs into Phosphatidylcholine and Phosphatidylcholine-Cholesterol Small Unilamellar Vesicles as Studied by Second-Derivative Spectrophotometry

The partition coefficients (Kps) of six anti-inflammatory steroid drugs, dexamethasone (DMS), betamethasone (BMS), triamcinolone acetonide (TCLA), fluocinolone acetonide (FCLA), betamethasone 17,21-dipropionate (BMSDP), and clobetasole propionate (CBSP), for phosphatidylcholine (PC), and PC-choleste...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2008/05/01, Vol.56(5), pp.663-667
Hauptverfasser:	Takegami, Shigehiko, Kitamura, Keisuke, Funakoshi, Takako, Kitade, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-Inflammatory Agents - chemistry Chemical Phenomena Chemistry, Physical Cholesterol - chemistry Dermatologic Agents - chemistry dermatological therapeutic potency Drug Carriers Drug Compounding Indicators and Reagents liposome Membranes, Artificial Particle Size partition coefficient Phosphatidylcholines - chemistry Phosphorus - analysis second-derivative spectrophotometry Spectrophotometry, Ultraviolet steroid drug Steroids - chemistry
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