Application and Mechanism of Inhalation Profile Improvement of DPI Formulations by Mechanofusion with Magnesium Stearate

In our previous paper, we reported the inhalation properties of dry powder inhaler (DPI) formulations containing Compound A and mechanofusion-processed lactose carriers. The mechanofusion process with magnesium stearate (Mg-St) on the lactose carrier enhanced the fine particle fraction (FPF) value o...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2008/05/01, Vol.56(5), pp.617-625
Hauptverfasser:	Kumon, Michiko, Machida, Satoshi, Suzuki, Masahiko, Kusai, Akira, Yonemochi, Etsuo, Terada, Katsuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Inhalation Algorithms Chemistry, Pharmaceutical Chromatography, Gas Chromatography, High Pressure Liquid Drug Carriers Drug Compounding dry powder inhaler Excipients lactose Lactose - chemistry magnesium stearate mechanofusion Microscopy, Electron, Scanning Powders Spectrophotometry, Ultraviolet Stearic Acids - administration & dosage Stearic Acids - chemistry Stearic Acids - pharmacokinetics Surface Properties surface property
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