Preparation and Evaluation of Immediate Release Ibuprofen Solid Dispersions Using Polyethylene Glycol 4000

To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and simple manner, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR), and evaluated for solubility, in-vitro...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2008/05/01, Vol.31(5), pp.939-945
Hauptverfasser:	Newa, Madhuri, Bhandari, Krishna Hari, Li, Dong Xun, Kim, Jong Oh, Yoo, Dong Sung, Kim, Jung-Ae, Yoo, Bong-Kyu, Woo, Jong-Soo, Choi, Han-Gon, Yong, Chul-Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics bioavailability Biological Availability Calorimetry, Differential Scanning Chemistry, Pharmaceutical dissolution Drug Compounding Emulsions Excipients ibuprofen Ibuprofen - administration & dosage Ibuprofen - chemistry Ibuprofen - pharmacokinetics Male Microscopy, Electron, Scanning polyethylene glycol 4000 Polyethylene Glycols - chemistry Rats Rats, Sprague-Dawley solid dispersion Solubility Spectroscopy, Fourier Transform Infrared Surface Properties
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