Altered collagen concentration in mitral valve leaflets: biochemical and finite element analysis

Background. Ischemic mitral regurgitation or ventricular wall motion abnormalities will alter the stress distribution in the mitral valve. We hypothesize that in response, the regional collagen concentration will be altered and will significantly impact the stress distribution in the mitral valve. M...

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Veröffentlicht in:	The Annals of thoracic surgery 1998-12, Vol.66 (6), p.S198-S205
Hauptverfasser:	Kunzelman, Karyn S, Quick, David W, Cochran, Richard P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemical Phenomena Biochemistry Biological and medical sciences Cardiology. Vascular system Chordae Tendineae - pathology Chordae Tendineae - physiopathology Collagen - analysis Collagen - physiology collagen concentration Coronary heart disease Elasticity Finite Element Analysis finite element model Heart hydroxyproline Hydroxyproline - analysis Medical sciences mitral valve Mitral Valve - chemistry Mitral Valve - pathology Mitral Valve - physiopathology Mitral Valve Insufficiency - pathology Mitral Valve Insufficiency - physiopathology Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Papillary Muscles - pathology Papillary Muscles - physiopathology Pressure Sheep Spectrophotometry stress Stress, Mechanical Ventricular Dysfunction - pathology Ventricular Dysfunction - physiopathology
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