Expression of 3‐hydroxyisobutyrate dehydrogenase in cultured neural cells

The branched‐chain amino acids (BCAAs) – isoleucine, leucine, and valine – belong to the limited group of substances transported through the blood–brain barrier. One of the functions they are thought to have in brain is to serve as substrates for meeting parenchymal energy demands. Previous studies...

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Veröffentlicht in:	Journal of neurochemistry 2008-05, Vol.105 (4), p.1176-1186
Hauptverfasser:	Murín, Radovan, Schaer, Andreas, Kowtharapu, Bhavani S., Verleysdonk, Stephan, Hamprecht, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐hydroxyisobutyrate 3‐hydroxyisobutyrate dehydrogenase Alcohol Oxidoreductases - biosynthesis Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - physiology Amino acids Animals Biochemistry Biological and medical sciences Brain Brain - cytology Brain - enzymology Brain - metabolism branched‐chain amino acid Cattle Cell culture Cells, Cultured Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases energy metabolism Energy Metabolism - physiology Enzymes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - physiology Humans Isolated neuron and nerve. Neuroglia Medical sciences Mice neural cells Neurology Neurons - cytology Neurons - enzymology Neurons - metabolism Rabbits Rats Rats, Wistar valine Valine - metabolism Vertebrates: nervous system and sense organs
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