Substance P regulates the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in cultured human gingival fibroblasts

Background and Objective: Substance P may play a role in the pathogenesis of periodontal disease; however, its mechanisms of modulation are not clear. This study evaluated the effect of two concentrations of Substance P on the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of...

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Veröffentlicht in:	Journal of periodontal research 2008-06, Vol.43 (3), p.255-260
Hauptverfasser:	Cury, P. R., Canavez, F., De Araújo, V. C., Furuse, C., De Araújo, N. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cells, Cultured Dentistry Dose-Response Relationship, Drug Enzyme Activation Fibroblasts - enzymology Gene Expression Gingiva - cytology Gingiva - enzymology gingival fibroblasts Humans matrix metalloproteinase Matrix Metalloproteinases - biosynthesis Medical sciences Otorhinolaryngology. Stomatology Polymerase Chain Reaction Statistics, Nonparametric Substance P Substance P - administration & dosage Substance P - pharmacology Substance P - physiology tissue inhibitor of metalloproteinase Tissue Inhibitor of Metalloproteinases - biosynthesis Up-Regulation
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