Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep
Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity–rest could maintain partial transformation of the LD. Methods. Sheep LD were burst-stimulated either 10 or 24 hours...
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| Veröffentlicht in: | The Annals of thoracic surgery 1998-12, Vol.66 (6), p.1983-1990 |
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| container_end_page | 1990 |
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| container_issue | 6 |
| container_start_page | 1983 |
| container_title | The Annals of thoracic surgery |
| container_volume | 66 |
| creator | Arpesella, Giorgio Carraro, Ugo Mikus, Piero M Dozza, Franco Lombardi, Pierloca Marinelli, Giuseppe Zampieri, Sandra El Messlemani, Abdul H Rossini, Katia Pierangeli, Angelo |
| description | Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity–rest could maintain partial transformation of the LD.
Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months.
Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation.
Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction. |
| doi_str_mv | 10.1016/S0003-4975(98)00906-0 |
| format | Article |
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Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months.
Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation.
Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(98)00906-0</identifier><identifier>PMID: 9930481</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cardiomyoplasty - methods ; Electric Stimulation Therapy ; Medical sciences ; Muscle Contraction - physiology ; Muscle, Skeletal - cytology ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Sheep ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors</subject><ispartof>The Annals of thoracic surgery, 1998-12, Vol.66 (6), p.1983-1990</ispartof><rights>1998 The Society of Thoracic Surgeons</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-d0711485bf79cd8b401c498b742326c01fd4517a2bb293926cbc46e72775c8a03</citedby><cites>FETCH-LOGICAL-c425t-d0711485bf79cd8b401c498b742326c01fd4517a2bb293926cbc46e72775c8a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0003-4975(98)00906-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1678066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9930481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arpesella, Giorgio</creatorcontrib><creatorcontrib>Carraro, Ugo</creatorcontrib><creatorcontrib>Mikus, Piero M</creatorcontrib><creatorcontrib>Dozza, Franco</creatorcontrib><creatorcontrib>Lombardi, Pierloca</creatorcontrib><creatorcontrib>Marinelli, Giuseppe</creatorcontrib><creatorcontrib>Zampieri, Sandra</creatorcontrib><creatorcontrib>El Messlemani, Abdul H</creatorcontrib><creatorcontrib>Rossini, Katia</creatorcontrib><creatorcontrib>Pierangeli, Angelo</creatorcontrib><title>Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity–rest could maintain partial transformation of the LD.
Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months.
Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation.
Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiomyoplasty - methods</subject><subject>Electric Stimulation Therapy</subject><subject>Medical sciences</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Sheep</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9qFTEUxkNR6rX6CIUsitTFaJLJXzelFP9BwUXrTgiZTIZGZia3OZnC7HwH39AnMbf3Upeukpzvy3fO-SF0Ssk7Sqh8f0MIaRtulDg3-i0hhsiGHKENFYI1kgnzDG2eLC_QS4Cf9cmqfIyOjWkJ13SDflz6Eh9iWf_8-p0DFAwlTsvoSkwzTgPe3QBqCXCfMkQ8pIy9y31M05q2o4OyfsC0WYPLuAYsYwEcZwx3IWxfoeeDGyG8Ppwn6Punj7dXX5rrb5-_Xl1eN54zUZqeKEq5Ft2gjO91xwn13OhOcdYy6Qkdei6ocqzrmGlNLXWey6CYUsJrR9oT9Gafu83pfqlb2CmCD-Po5pAWsNJQobUQ1Sj2Rp8TQA6D3eY4ubxaSuyOqn2kanfIrNH2kardNTg9NFi6KfRPvw4Yq3520B14Nw7ZzT7Cv3CpNJGy2i72tlBhPMSQLfgYZh_6mIMvtk_xP4P8BQpMlQ8</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Arpesella, Giorgio</creator><creator>Carraro, Ugo</creator><creator>Mikus, Piero M</creator><creator>Dozza, Franco</creator><creator>Lombardi, Pierloca</creator><creator>Marinelli, Giuseppe</creator><creator>Zampieri, Sandra</creator><creator>El Messlemani, Abdul H</creator><creator>Rossini, Katia</creator><creator>Pierangeli, Angelo</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep</title><author>Arpesella, Giorgio ; Carraro, Ugo ; Mikus, Piero M ; Dozza, Franco ; Lombardi, Pierloca ; Marinelli, Giuseppe ; Zampieri, Sandra ; El Messlemani, Abdul H ; Rossini, Katia ; Pierangeli, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-d0711485bf79cd8b401c498b742326c01fd4517a2bb293926cbc46e72775c8a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiomyoplasty - methods</topic><topic>Electric Stimulation Therapy</topic><topic>Medical sciences</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Sheep</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arpesella, Giorgio</creatorcontrib><creatorcontrib>Carraro, Ugo</creatorcontrib><creatorcontrib>Mikus, Piero M</creatorcontrib><creatorcontrib>Dozza, Franco</creatorcontrib><creatorcontrib>Lombardi, Pierloca</creatorcontrib><creatorcontrib>Marinelli, Giuseppe</creatorcontrib><creatorcontrib>Zampieri, Sandra</creatorcontrib><creatorcontrib>El Messlemani, Abdul H</creatorcontrib><creatorcontrib>Rossini, Katia</creatorcontrib><creatorcontrib>Pierangeli, Angelo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arpesella, Giorgio</au><au>Carraro, Ugo</au><au>Mikus, Piero M</au><au>Dozza, Franco</au><au>Lombardi, Pierloca</au><au>Marinelli, Giuseppe</au><au>Zampieri, Sandra</au><au>El Messlemani, Abdul H</au><au>Rossini, Katia</au><au>Pierangeli, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>66</volume><issue>6</issue><spage>1983</spage><epage>1990</epage><pages>1983-1990</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Background. In dynamic cardiomyoplasty electrostimulation achieves full transformation of the latissimus dorsi (LD); therefore, its slowness limits the systolic support. Daily activity–rest could maintain partial transformation of the LD.
Methods. Sheep LD were burst-stimulated either 10 or 24 hours/day. Before and 2, 4, 6, and 12 months after stimulation, LD power output, fatigue resistance, and tetanic fusion frequency were assessed. Latissimus dorsi were biopsied at 6 months, and sheep sacrificed at 12 months.
Results. After 1 year of 10 hours/day stimulation LD was substantially conserved and contained large amounts of fast type myosin. From 2 months to 1 year of stimulation the power per muscle of the daily rested LD was greater than that of the left ventricle, being three to four times higher than in the 24-hour/day stimulation.
Conclusions. If extended to humans, these results could be the rationale for the need of a cardiomyostimulator, whose discontinuous activity could offer to patients the long-standing advantage of a faster and powerful muscle contraction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9930481</pmid><doi>10.1016/S0003-4975(98)00906-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cardiomyoplasty - methods Electric Stimulation Therapy Medical sciences Muscle Contraction - physiology Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Sheep Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors |
| title | Activity–rest stimulation of latissimus dorsi for cardiomyoplasty: 1-year results in sheep |
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