A retroviral vector system 'STITCH' in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes

Genetic engineering of T lymphocytes for adoptive clinical immunotherapy calls for efficient gene transduction methods. Therefore, a transient retroviral gene transduction system 'STITCH' was developed comprising pSTITCH retroviral vector encoding the transgene, plasmids encoding Moloney m...

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Veröffentlicht in:	Gene therapy 1998-09, Vol.5 (9), p.1195-1203
Hauptverfasser:	WEIJTENS, M. E. M, WILLEMSEN, R. A, HART, E. H, BOLHUIS, R. L. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - therapy Cell Membrane - metabolism Cytolysis Fundamental and applied biological sciences. Psychology Gag protein Gene Expression Gene therapy Genetic engineering Genetic Therapy - methods Genetic Vectors Health. Pharmaceutical industry Humans Immunotherapy Industrial applications and implications. Economical aspects Kidney cancer Kidney Neoplasms - immunology Kidney Neoplasms - therapy Leukemia Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - metabolism Packaging Plasmids Receptors, Antigen, T-Cell - genetics Receptors, Immunologic - genetics Recombinant Fusion Proteins - genetics Renal cell carcinoma Retroviridae - genetics Transduction Transduction, Genetic Tumor Cells, Cultured
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